Search Results (10)

Delivery systems are ubiquitous in today’s economy. However, those systems usually operate through purpose-built vehicles, which are inefficient, expensive, and highly harmful to the environment. We propose an optimal route crowd-shipping (OR-CS) system, a delivery service based on crowd transportation. The OR-CS system utilizes service points (SPs) and occasional couriers (OCs) to transfer deliveries. Senders drop packages at SPs, while receivers collect them from different SPs. The system is based on a new algorithm that assigns to each package an optimal route. The route is chosen individually for the package and is personally tailored according to the sender’s preferences and to the predefined routes of the OCs. To assess the real-life feasibility of the system, we developed a general simulator that emulates a city environment with authentic service points specifically selected based on desired attributes. The routes of OCs and the origins and destinations of packages were generated using a random process that differed between simulations. The results indicate that the system can be implemented and utilized. In addition, it yields positive results when the number of OCs surpasses a minimum threshold, which is feasible in most cities, given existing traffic loads. By adopting OR-CS, we can expect lowered delivery costs, reduced traffic congestion, and enhanced environmental sustainability. Full article

Plasma generation by cathodic arc spots plays a crucial role for coating processes that make use of the Arc-PVD technology. Usually, the arc spot motion over the cathode is steered by a magnetic field of a particular distribution and magnitude to ensure a continuous plasma generation, the avoidance of liquid droplets, and a proper utilization of cathode material by homogeneous erosion. This study presents a semi-empirical model that allows for an examination and characterization of the arc spot motion with regard to direction and speed as a function of an imposed magnetic field. This model considers the different components of random walk, retrograde, and Robson drift motion. Introduced empirical coefficients were determined by corresponding experimental investigations. The calibrated model describes the arc spot motion in good agreement to the recorded spot tracks and can therefore be applied for an evaluation of different magnetic field configurations. Full article

The eyes are in constant movement to optimize the interpretation of the visual scene by the brain. Eye movements are controlled by complex neural networks that interact with the rest of the brain. The direction of our eye movements could thus be influenced by our cognitive activity (imagination, internal dialogue, memory, etc.). A given cognitive activity could then cause the gaze to move in a specific direction (a brief movement that would be instinctive and unconscious). Neuro Linguistic Programming (NLP), which was developed in the 1970s by Richard Bandler and John Grinder (psychologist and linguist respectively), issued a comprehensive theory associating gaze directions with specific mental tasks. According to this theory, depending on the visual path observed, one could go back to the participant's thoughts and cognitive processes. Although NLP is widely used in many disciplines (communication, psychology, psychotherapy, marketing, etc), to date, few scientific studies have examined the validity of this theory. Using eye tracking, this study explores one of the hypotheses of this theory, which is one of the pillars of NLP on visual language. We created a protocol based on a series of questions of different types (supposed to engage different brain areas) and we recorded by eye tracking the gaze movements at the end of each question while the participants were thinking and elaborating on the answer. Our results show that (1) complex questions elicit significantly more eye movements than control questions that necessitate little reflection, (2) the movements are not random but are oriented in selected directions, according to the different question types, (3) the orientations observed are not those predicted by the NLP theory. This pilot experiment paves the way for further investigations to decipher the close links between eye movements and neural network activities in the brain. Full article

Microsaccades are at the interface between basic oculomotor phenomena and complex processes of cognitive functioning, and they also have been a challenge for subtle experimentation and adequate statistical analysis. In the second part of the special thematic issue (for the first part see Martinez-Conde, Engbert, & Groner, 2020) the authors present a series of articles which demonstrate that microsaccades are still an interesting and rewarding area of scientific research the forefront of research in many areas of sensory, perceptual, and cognitive processes. In their article “Pupillary and microsaccadic responses to cognitive effort and emotional arousal during complex decision making” Krejtz, Żurawska, Duchowski, & Wichary (2020) investigate pupillary and microsaccadic responses to information processing during multi-attribute decision making under affective priming. The participants were randomly assigned into three affective priming conditions (neutral, aversive, and erotic) and instructed to make discriminative decisions. As hypothesized by the authors, the results showed microsaccadic rate inhibition and pupillary dilation, depending on cognitive effort prior to decision and moderated by affective priming. Aversive priming increased pupillary and microsaccadic responses to information processing effort. The results indicate that pupillary response is more influenced by affective priming than microsaccadic rate. The results are discussed in the light of neuropsychological mechanisms of pupillary and microsaccadic behavior. In the article “Microsaccadic rate signatures correlate under monocular and binocular stimulation conditions” Essig, Leube, Rifai, & Wahl (2020) investigate microsaccades with respect to their directional distribution and rate under monocular and binocular conditions. In both stimulation conditions participants fixated a Gabor patch presented randomly in orientation of 45° or 135° over a wide range of spatial frequencies. Microsaccades were mostly horizontally oriented regardless of the spatial frequency of the grating. This outcome was consistent between both stimulation conditions. This study found that the microsaccadic rate signature curve correlates between both stimulation conditions, therefore extending the use of microsaccades to clinical applications, since parameters as contrast sensitivity, have frequently been measured monocularly in the clinical studies. The study “Microsaccades during high speed continuous visual search” by Martin, Davis, Riesenhuber, & Thorpe (2020) provides an analysis of the microsaccades occurring during visual search, targeting to small faces pasted either into cluttered background photos or into a simple gray background. Participants were instructed to target singular 3-degree upright or inverted faces in changing scenes. As soon as the participant’s gaze reached the target face, a new face was displayed in a different random location. Regardless of the experimental context (e.g., background scene, no background scene), or target eccentricity (from 4 to 20 degrees of visual angle), The authors found that the microsaccade rate dropped to near zero levels within 12 ms. There were almost never any microsaccades after stimulus onset and before the first saccade to the face. In about 20% of the trials, there was a single microsaccade that occurred almost immediately after the preceding saccade’s offset. The authors argue that a single feedforward pass through the visual hierarchy of processing a stimulus is needed to effectuate prolonged continuous visual search and provide evidence that microsaccades can serve perceptual functions like correcting saccades or effectuating task-oriented goals during continuous visual search. While many studies have characterized the eye movements during visual fixation, including microsaccades, in most cases only horizontal and vertical components have been recorded and analyzed. Little is known about the torsional component of microsaccades. In the study “Torsional component of microsaccades during fixation and quick phases during optokinetic stimulation” Sadeghpour & Otero-Millan (2020) recorded eye movements around the three axes of rotation during fixation and torsional optokinetic stimulus. The authors found that the average amplitude of the torsional component of microsaccades during fixation was 0.34 ± 0.07 degrees with velocities following a main sequence with a slope comparable to the horizontal and vertical components. The size of the torsional displacement during microsaccades was correlated with the horizontal but not the vertical component. In the presence of an optokinetic stimulus a nystagmus was induced producing more frequent and larger torsional quick phases compared to microsaccades produced during fixation of a stationary stimulus. The torsional component and the vertical vergence component of quick phases increased with higher velocities. In previous research, microsaccades have been interpreted as psychophysiological indicators of task load. So far, it is still under debate how different types of task demands are influencing microsaccade rate. In their article “The interplay between task difficulty and microsaccade rate: Evidence for the critical role of visual load” Schneider et al. (1921) examined the relation between visual load, mental load and microsaccade rate. The participants carried out a continuous performance task (n-back) in which visual task load (letters vs. abstract figures) and mental task load (1-back to 4-back) were manipulated as within-subjects variables. Eye tracking data, performance data as well as subjective workload were recorded. Data analysis revealed an increased level of microsaccade rate for stimuli of high visual demand (i.e., abstract figures), while mental demand (n-back-level) did not modulate microsaccade rate. The authors concluded that microsaccade rate reflects visual load of a task rather than its mental load. This conclusion is in accordance with the proposition of Krueger et al. (2019) “Microsaccades distinguish looking from seeing”, linking sensory with cognitive phenomena. The present special thematic issue adds several new interesting facets to the research landscape around microsaccades. They still remain an attractive focus of interdisciplinary research and transdisciplinary applications. Thus, as already noted in the first part of this special thematic issue, research on microsaccades will not only endure, but keep evolving as the knowledge base expands. Full article

Active vitamin D is a true steroid hormone with pleiotropic biological effects that go beyond the classical concept of bone metabolism regulation. In fact, adequate serum levels of 25-hydroxyvitamin D (>40 ng/mL) are required to support several biological functions, including the control of innate and adaptive immunity in course of infectious, inflammatory and autoimmune diseases. SARS-CoV-2 is responsible for the COVID-19 pandemic and deficient/insufficient serum levels of 25-hydroxyvitamin D are reported in very large cohorts of patients. Of note, vitamin D is involved in different pathophysiological processes, such as expression of SARS-CoV-2 receptor (ACE2), activation of innate (neutrophils with their extracellular traps, monocytes/macrophages, dendritic cells, natural killer cells) and adaptive (T and B lymphocytes) immune cells and clinical manifestations, such as coagulation/thrombotic disorders and acute respiratory distress syndrome. Randomized clinical trials regarding vitamin D supplementation in COVID-19 patients have shown favorable effects on the control of inflammation markers, arterial oxygen saturation/inspired fraction of oxygen ratio, admission to hospital intensive care units and mortality. A target of serum 25-hydroxyvitamin D > 50 ng/mL has been identified as protective for the course of COVID-19, potentially playing an ancillary role in the treatment of the disease. Full article

Goal programming (GP) can be thought of as an extension or generalization of linear programming to handle multiple, normally conflicting objective measures. Each of these measures is given a goal or target value to be achieved. Unwanted deviations from this set of target values are then minimized in an achievement function. Production planning is an important process that aims to leverage the resources available in industry to achieve one or more business goals. However, the production planning that typically uses mathematical models has its own challenges where parameter models are sometimes difficult to find easily and accurately. Data collected with various data collection methods and human experts’ judgments are often prone to uncertainties that can affect the information presented by quantitative results. This study focuses on resolving data uncertainties as well as multi-objective optimization using fuzzy random methods and GP in production planning problems. GP was enhanced with fuzzy random features. Scalable approaches and maximum minimum operators were then used to solve multi-object optimization problems. Scaled indices were also introduced to resolve fuzzy symbols containing unspecified relationships. The application results indicate that the proposed approach can mitigate the characteristics of uncertainty in the analysis and achieve a satisfactory optimized solution. Full article

In this article, we propose a review of studies evaluating the distribution of distances between elements of a random set independently and uniformly distributed over a region of space in a normed $\mathbb{R}$ -vector space (for example, point events generated by a homogeneous Poisson process in a compact set). The distribution of distances between individuals is present in many situations when interaction depends on distance and concerns many disciplines, such as statistical physics, biology, ecology, geography, networking, etc. After reviewing the solutions proposed in the literature, we present a modern, general and unified resolution method using convolution of random vectors. We apply this method to typical compact sets: segments, rectangles, disks, spheres and hyperspheres. We show, for example, that in a hypersphere the distribution of distances has a typical shape and is polynomial for odd dimensions. We also present various applications of these results and we show, for example, that variance of distances in a hypersphere tends to zero when space dimension increases. Full article

This work presents the analysis of data recorded by an eye tracking device in the course of evaluating a foveated rendering approach for head-mounted displays (HMDs). Foveated rendering methods adapt the image synthesis process to the user’s gaze and exploiting the human visual system’s limitations to increase rendering performance. Especially, foveated rendering has great potential when certain requirements have to be fulfilled, like low-latency rendering to cope with high display refresh rates. This is crucial for virtual reality (VR), as a high level of immersion, which can only be achieved with high rendering performance and also helps to reduce nausea, is an important factor in this field. We put things in context by first providing basic information about our rendering system, followed by a description of the user study and the collected data. This data stems from fixation tasks that subjects had to perform while being shown fly-through sequences of virtual scenes on an HMD. These fixation tasks consisted of a combination of various scenes and fixation modes. Besides static fixation targets, moving targets on randomized paths as well as a free focus mode were tested. Using this data, we estimate the precision of the utilized eye tracker and analyze the participants’ accuracy in focusing the displayed fixation targets. Here, we also take a look at eccentricity-dependent quality ratings. Comparing this information with the users’ quality ratings given for the displayed sequences then reveals an interesting connection between fixation modes, fixation accuracy and quality ratings. Full article

A popular approach in the investigation of the short-term behavior of a non-stationary time series is to assume that the time series decomposes additively into a long-term trend and short-term fluctuations. A first step towards investigating the short-term behavior requires estimation of the trend, typically via smoothing in the time domain. We propose a method for time-domain smoothing, called complexity-regularized regression (CRR). This method extends recent work, which infers a regression function that makes residuals from a model “look random”. Our approach operationalizes non-randomness in the residuals by applying ideas from computational mechanics, in particular the statistical complexity of the residual process. The method is compared to generalized cross-validation (GCV), a standard approach for inferring regression functions, and shown to outperform GCV when the error terms are serially correlated. Regression under serially-correlated residuals has applications to time series analysis, where the residuals may represent short timescale activity. We apply CRR to a time series drawn from the Dow Jones Industrial Average and examine how both the long-term and short-term behavior of the market have changed over time. Full article

We describe the development and implementation of a randomized controlled trial to investigate the impact of genomic counseling on a cohort of patients with heart failure (HF) or hypertension (HTN), managed at a large academic medical center, the Ohio State University Wexner Medical Center (OSUWMC). Our study is built upon the existing Coriell Personalized Medicine Collaborative (CPMC^®). OSUWMC patient participants with chronic disease (CD) receive eight actionable complex disease and one pharmacogenomic test report through the CPMC^® web portal. Participants are randomized to either the in-person post-test genomic counseling—active arm, versus web-based only return of results—control arm. Study-specific surveys measure: (1) change in risk perception; (2) knowledge retention; (3) perceived personal control; (4) health behavior change; and, for the active arm (5), overall satisfaction with genomic counseling. This ongoing partnership has spurred creation of both infrastructure and procedures necessary for the implementation of genomics and genomic counseling in clinical care and clinical research. This included creation of a comprehensive informed consent document and processes for prospective return of actionable results for multiple complex diseases and pharmacogenomics (PGx) through a web portal, and integration of genomic data files and clinical decision support into an EPIC-based electronic medical record. We present this partnership, the infrastructure, genomic counseling approach, and the challenges that arose in the design and conduct of this ongoing trial to inform subsequent collaborative efforts and best genomic counseling practices. Full article