Search Results (6)

Background: There is a considerable overlap between the clinical presentation of post-COVID-19 condition (PCC) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Many of their common symptoms can be linked to dysregulation of the autonomic nervous system (dysautonomia). This study aimed to objectively assess autonomic function in a general group of patients with PCC and in a group of patients with ME/CFS whose disease was not related to COVID-19. We hypothesize that the similarity in the chronic symptoms of patients with PCC and ME/CFS extends to objective autonomic nervous system abnormalities. Methods: Synchronous recordings of an electrocardiogram and continuous dynamics of blood pressure in the digital artery using the Penaz method were obtained using the spiroarteriocardiorhythmography method in 34 patients diagnosed with ME/CFS, in whom the onset of the disease was not associated with COVID-19, 29 patients meeting the PCC definition and 32 healthy controls. Heart rate variability (HRV) and systolic and diastolic blood pressure variability (BPV) were assessed at rest and in tests with fixed respiratory rates. Indicators of baroreflex regulation (baroreflex effectiveness index and baroreflex sensitivity) were additionally determined at rest. Results: The total power and power of low-frequency and high-frequency of RR interval variability at rest as well as baroreflex sensitivity were significantly lower both in PCC and ME/CFS patients compared to healthy controls. Several diagnostic prediction models for ME/CFS were developed based on HRV parameters. During slow breathing, the HRV parameters returned to normal in PCC but not in ME/CFS patients. The correlation analysis revealed a close relationship of HRV, BPV parameters and baroreflex sensitivity with fatigue, but not with HADS depressive/anxiety symptoms in the ME/CFS and PCC patients. Conclusions: A similar pattern of HRV and baroreflex failure with signs of a pathological acceleration of age-dependent dysautonomia was identified in the ME/CFS and PCC patients. The clinical, diagnostic and therapeutic implications of these findings are discussed, in light of previously described relationships between inflammation, vascular pathology, atherosclerotic cardiovascular disease and autonomic dysfunction. Full article

Oyster farming may impact the estuarine tidal circulation with a series of effects on environmental conditions and cultures’ growth. Hydrodynamic numerical models set up in estuaries integrated the presence of oyster structures by simply increasing the bottom friction coefficient over farming areas. However, for elevated oyster tables in tidal environments, such default calibration ignored the temporal variations of the friction coefficient between the conditions of submerged or unsubmerged structures. Thus, an original formulation of the Chézy coefficient was here proposed to integrate these modulations. Assessed against measured and predicted vertical velocity profiles on a 1/2 scaled model, this formulation was implemented in a simulation of the tidal circulation within the Aber Wrac’h estuary (Brittany, France). Particular attention was dedicated to the changes induced on the current magnitudes and sediment transport. Oyster tables were found to impact current magnitudes in the vicinity of elevated structures, with major differences at times of local peak flood and ebb. These modifications were characterised by (i) a reduction of current magnitudes over oyster farming areas and (ii) a tidal-flow acceleration on both sides of these structures. Increased sediment transport was, therefore, expected in the vicinity of these cultures, with potential implications on seabed morphology and water quality. Full article

The deterioration of ride comfort in ultra-compact vehicles has recently become an increasing concern. Active seat suspension was proposed to improve the ride comfort of ultra-compact vehicles. An active seat suspension is a vibration control device that is easily installed. The general vibration control system of the active seat suspension is fed back to the displacement and velocity by integrating the measured seat acceleration. This control has problems, such as control delay and deviation by integration. In this study, we focused on vibration control using acceleration directly. First, we established a control model that feeds back the acceleration to terminate the error occurring in the integral process and investigated the change in vibration characteristics in the case where the feedback gain of acceleration was changed. Second, the control system was analyzed to investigate the performance of the control based on the frequency characteristics. As a result, it was confirmed that the frequency response changes when the feedback gain is changed. In acceleration feedback control, ride comfort was improved by selecting a proper feedback gain because the characteristics of frequency were changed by the gain. Full article

Pavement structures cover vast areas of urban cities and non-urban roads and play a key role in daily commuting functionality and economic development; therefore, they must be conserved against any distress. The rutting problem, being a major distress to the pavement structure, must be solved and dealt with in order to preserve its value. One way of solving this dilemma is by using geo-grids within the pavement structure. A geo-grid is a synthetic material usually made from polymers with different thicknesses and stiffnesses. This paper investigates the effects of geo-grids on reducing the rutting occurrence through adding a layer of geo-grid with certain properties at different levels of the pavement structure. We also investigate, the result of the added geo-grid material to the developed vertical stresses within the pavement cross-section. This investigation is conducted by constructing a 3-D finite elements-based (FE) model of a pavement cross-section using ANSYS software; student version R1 2021. The FE-based model is validated by comparing its numerical predictions with the experimental results acquired from an accelerated large-scale paved model. The results show that the deeper the geo-grid is positioned, the more significant the rutting resistance is observed due to the stiffness of the geo-grid bearing the tensile force until a certain depth. Moreover, noticeable stress reduction is seen in the developed vertical compressive stresses below the loading area resisted by the geo-grid. Full article

Obtaining precise attitude information is essential for aircraft navigation and control. This paper presents the results of the attitude determination using an in-house designed low-cost MEMS-based flight information measurement unit. This study proposes a quaternion-based extended Kalman filter to integrate the traditional quaternion and gravitational force decomposition methods for attitude determination algorithm. The proposed extended Kalman filter utilizes the evolution of the four elements in the quaternion method for attitude determination as the dynamic model, with the four elements as the states of the filter. The attitude angles obtained from the gravity computations and from the electronic magnetic sensors are regarded as the measurement of the filter. The immeasurable gravity accelerations are deduced from the outputs of the three axes accelerometers, the relative accelerations, and the accelerations due to body rotation. The constraint of the four elements of the quaternion method is treated as a perfect measurement and is integrated into the filter computation. Approximations of the time-varying noise variances of the measured signals are discussed and presented with details through Taylor series expansions. The algorithm is intuitive, easy to implement, and reliable for long-term high dynamic maneuvers. Moreover, a set of flight test data is utilized to demonstrate the success and practicality of the proposed algorithm and the filter design. Full article

Angiosperm genomes differ from those of mammals by extensive and recursive polyploidizations. The resulting gene duplication provides opportunities both for genetic innovation, and for concerted evolution. Though most genes may escape conversion by their homologs, concerted evolution of duplicated genes can last for millions of years or longer after their origin. Indeed, paralogous genes on two rice chromosomes duplicated an estimated 60–70 million years ago have experienced gene conversion in the past 400,000 years. Gene conversion preserves similarity of paralogous genes, but appears to accelerate their divergence from orthologous genes in other species. The mutagenic nature of recombination coupled with the buffering effect provided by gene redundancy, may facilitate the evolution of novel alleles that confer functional innovations while insulating biological fitness of affected plants. A mixed evolutionary model, characterized by a primary birth-and-death process and occasional homoeologous recombination and gene conversion, may best explain the evolution of multigene families. Full article