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Authors = Roxana Ștefănescu

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20 pages, 7547 KiB  
Case Report
Is Sentinel Lymph Node Biopsy Feasible in Multicentric Breast Cancer? A Case Report and Literature Review
by Mihaela Camelia Tîrnovanu, Elena Cojocaru, Vlad Gabriel Tîrnovanu, Elena Țarcă, Loredana Toma, Bogdan Florin Toma, Sorana Anton, Ștefan Dragoș Tîrnovanu, Roxana Ana Covali, Cipriana Ștefănescu and Irena Cristina Grierosu
Life 2025, 15(7), 1018; https://doi.org/10.3390/life15071018 - 26 Jun 2025
Viewed by 588
Abstract
Accurate lymph node staging is crucial for both prognosis (in the event of early-stage disease) and treatment (for local control of disease) in patients with breast cancer. Sentinel lymph node biopsy (SLNB) has been studied in numerous international trials, showing that it allows [...] Read more.
Accurate lymph node staging is crucial for both prognosis (in the event of early-stage disease) and treatment (for local control of disease) in patients with breast cancer. Sentinel lymph node biopsy (SLNB) has been studied in numerous international trials, showing that it allows about 70% of axillary lymph node dissection (ALND) to be avoided and thus significantly reduces the morbidity associated with ALND. SLNB represents a necessary step in the diagnostic algorithm for breast neoplasms because the surgical treatment for breast cancer has become progressively less invasive. We present a case of a 70-year-old woman with multicentric breast cancer (MBC) treated by surgery at “Cuza Vodă” Women’s University Hospital, Iassy, Romania. In this case, only the ultrasonography established the diagnosis of left MBC with certainty. Conclusion: The detection of sentinel lymph nodes (SLNs) for MBC must be indicated. In this type of cancer, SLNB is accurate and practical, with sufficient quality control and interdisciplinary collaboration between surgical, nuclear medicine, and pathology units. Lymphoscintigraphy allows the patient to avoid axillary clearance surgery if the sentinel node is negative for metastatic disease. The variability of Ki67, PR, HER2, and ER status supports the idea that all individual foci should be tested in MBC cases to provide the best management and prognosis. Full article
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19 pages, 374 KiB  
Article
The Impact of the COVID-19 Pandemic on Quality Education of the Medical Young Generation
by Daniela Roxana Matasariu, Ludmila Lozneanu, Iuliana Elena Bujor, Alexandra Elena Cristofor, Cristina Elena Mandici, Marcel Alexandru Găină, Cristinel Ștefănescu, Vasile Lucian Boiculese, Ioana Popescu, Laura Stătescu, Andreea Rusu, Simona Eliza Giusca and Alexandra Ursache
Int. J. Environ. Res. Public Health 2023, 20(5), 3953; https://doi.org/10.3390/ijerph20053953 - 23 Feb 2023
Viewed by 2060
Abstract
(1) Generating the need to impose social distancing to reduce the spread of the virus, the COVID-19 pandemic altered the ways in which the teaching process normally happens. The aim of our study was to determine the impact of online teaching on medical [...] Read more.
(1) Generating the need to impose social distancing to reduce the spread of the virus, the COVID-19 pandemic altered the ways in which the teaching process normally happens. The aim of our study was to determine the impact of online teaching on medical students during this period. (2) Our study included 2059 medical, dental and pharmacy students from the University of Medicine and Pharmacy “Grigore T. Popa”, Iasi, Romania. We used a modified metacognition questionnaire after translation into Romanian and validation. Our questionnaire included 38 items, and it was divided into four parts. Academic results and preferences regarding the on-site or online courses, information regarding practical training, self-awareness in terms of one’s feelings such as anger, boredom and anxiety and also substance use linked to online teaching, and contextualization of the relationship with colleagues, teachers, friends and family were among the most important points evaluated. A comparison was made between preclinical and clinical students. A five-item Linkert-like scale was used for rating the answers in the last three parts that evaluated the impact of the SARS-CoV-2 pandemic on the educational process. (3) Preclinical medical students, compared to preclinical dental students, obtained statistically significant improvements in their evaluation results, with fewer failed exams (p < 0.001) and with similar results being obtained by comparing dental with pharmacy students. All students obtained statistically significant improvements in their academic results during the online evaluation. A statistically significant increase in anxiety and depression with a p-value of <0.001 was registered among our students. (4) The majority found it difficult to cope with this intense period. Both teachers and students found it difficult to adjust on such short notice to the challenges posed by the new concept of online teaching and learning. Full article
(This article belongs to the Special Issue Social and Emotional Impact of the COVID-19 Pandemic)
24 pages, 3974 KiB  
Systematic Review
Big Data Management Algorithms, Deep Learning-Based Object Detection Technologies, and Geospatial Simulation and Sensor Fusion Tools in the Internet of Robotic Things
by Mihai Andronie, George Lăzăroiu, Mariana Iatagan, Iulian Hurloiu, Roxana Ștefănescu, Adrian Dijmărescu and Irina Dijmărescu
ISPRS Int. J. Geo-Inf. 2023, 12(2), 35; https://doi.org/10.3390/ijgi12020035 - 21 Jan 2023
Cited by 105 | Viewed by 9706
Abstract
The objective of this systematic review was to analyze the recently published literature on the Internet of Robotic Things (IoRT) and integrate the insights it articulates on big data management algorithms, deep learning-based object detection technologies, and geospatial simulation and sensor fusion tools. [...] Read more.
The objective of this systematic review was to analyze the recently published literature on the Internet of Robotic Things (IoRT) and integrate the insights it articulates on big data management algorithms, deep learning-based object detection technologies, and geospatial simulation and sensor fusion tools. The research problems were whether computer vision techniques, geospatial data mining, simulation-based digital twins, and real-time monitoring technology optimize remote sensing robots. Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines were leveraged by a Shiny app to obtain the flow diagram comprising evidence-based collected and managed data (the search results and screening procedures). Throughout January and July 2022, a quantitative literature review of ProQuest, Scopus, and the Web of Science databases was performed, with search terms comprising “Internet of Robotic Things” + “big data management algorithms”, “deep learning-based object detection technologies”, and “geospatial simulation and sensor fusion tools”. As the analyzed research was published between 2017 and 2022, only 379 sources fulfilled the eligibility standards. A total of 105, chiefly empirical, sources have been selected after removing full-text papers that were out of scope, did not have sufficient details, or had limited rigor For screening and quality evaluation so as to attain sound outcomes and correlations, we deployed AMSTAR (Assessing the Methodological Quality of Systematic Reviews), AXIS (Appraisal tool for Cross-Sectional Studies), MMAT (Mixed Methods Appraisal Tool), and ROBIS (to assess bias risk in systematic reviews). Dimensions was leveraged as regards initial bibliometric mapping (data visualization) and VOSviewer was harnessed in terms of layout algorithms. Full article
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16 pages, 1895 KiB  
Article
Role of Diphosphonates Bone Scintigraphy in Correlation with Biomarkers for a Personalized Approach to ATTR Cardiac Amyloidosis in North-Eastern Romania
by Teodor Marian Ionescu, Manuela Ciocoiu, Raoul-Vasile Lupușoru, Irena Grierosu, Radu Andy Sascău, Wael Jalloul, Roxana Iacob, Cati Raluca Stolniceanu, Alexandra Clement, Ana-Maria Stătescu, Daniela Crișu, Antoniu Octavian Petriș, Florin Mitu and Cipriana Ștefănescu
Diagnostics 2023, 13(1), 83; https://doi.org/10.3390/diagnostics13010083 - 28 Dec 2022
Cited by 2 | Viewed by 2199
Abstract
Transthyretin cardiac amyloidosis (ATTR) is a rare cardiac protein deposition disease characterized by progressive thickening of both ventricles, the inter-atrial-ventricular septum and the atrioventricular valves. The gold standard method for diagnosing this rare pathology is endomyocardial biopsy. If this method cannot be used, [...] Read more.
Transthyretin cardiac amyloidosis (ATTR) is a rare cardiac protein deposition disease characterized by progressive thickening of both ventricles, the inter-atrial-ventricular septum and the atrioventricular valves. The gold standard method for diagnosing this rare pathology is endomyocardial biopsy. If this method cannot be used, the alternative is a mixture of clinical and paraclinical tests. Over the course of five years, we examined 58 patients suspected of cardiac amyloidosis based on electrocardiography and ultrasonography criteria, who had been sent for bone scintigraphy in order to determine the presence of ATTR cardiac amyloidosis. However, the final diagnosis was set by correlating the bone scan with genetic testing, free light chain dosage or soft tissue biopsy. Based on the final diagnosis we analyzed the patients’ predominant biomarkers in order to determine a possible correlation between them. This analysis is designed to help the general practitioner set a possible cardiac amyloidosis diagnosis. Full article
(This article belongs to the Section Pathology and Molecular Diagnostics)
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32 pages, 1434 KiB  
Review
Remote Big Data Management Tools, Sensing and Computing Technologies, and Visual Perception and Environment Mapping Algorithms in the Internet of Robotic Things
by Mihai Andronie, George Lăzăroiu, Oana Ludmila Karabolevski, Roxana Ștefănescu, Iulian Hurloiu, Adrian Dijmărescu and Irina Dijmărescu
Electronics 2023, 12(1), 22; https://doi.org/10.3390/electronics12010022 - 21 Dec 2022
Cited by 114 | Viewed by 6555
Abstract
The purpose of our systematic review was to inspect the recently published research on Internet of Robotic Things (IoRT) and harmonize the assimilations it articulates on remote big data management tools, sensing and computing technologies, and visual perception and environment mapping algorithms. The [...] Read more.
The purpose of our systematic review was to inspect the recently published research on Internet of Robotic Things (IoRT) and harmonize the assimilations it articulates on remote big data management tools, sensing and computing technologies, and visual perception and environment mapping algorithms. The research problems were whether robotic manufacturing processes and industrial wireless sensor networks shape IoRT and lead to improved product quality by use of remote big data management tools, whether IoRT devices communicate autonomously regarding event modeling and forecasting by leveraging machine learning and clustering algorithms, sensing and computing technologies, and image processing tools, and whether smart connected objects, situational awareness algorithms, and edge computing technologies configure IoRT systems and cloud robotics in relation to distributed task coordination through visual perception and environment mapping algorithms. A Shiny app was harnessed for Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines to configure the flow diagram integrating evidence-based gathered and processed data (the search outcomes and screening procedures). A quantitative literature review of ProQuest, Scopus, and the Web of Science databases was carried out throughout June and October 2022, with search terms including “Internet of Robotic Things” + “remote big data management tools”, “sensing and computing technologies”, and “visual perception and environment mapping algorithms”. Artificial intelligence and intelligent workflows by use of AMSTAR (Assessing the Methodological Quality of Systematic Reviews), Dedoose, DistillerSR, and SRDR (Systematic Review Data Repository) have been deployed as data extraction tools for literature collection, screening, and evaluation, for document flow monitoring, for inspecting qualitative and mixed methods research, and for establishing robust outcomes and correlations. For bibliometric mapping by use of data visualization, Dimensions AI was leveraged and with regards to layout algorithms, VOSviewer was harnessed. Full article
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26 pages, 552 KiB  
Review
Deep Learning-Assisted Smart Process Planning, Robotic Wireless Sensor Networks, and Geospatial Big Data Management Algorithms in the Internet of Manufacturing Things
by George Lăzăroiu, Mihai Andronie, Mariana Iatagan, Marinela Geamănu, Roxana Ștefănescu and Irina Dijmărescu
ISPRS Int. J. Geo-Inf. 2022, 11(5), 277; https://doi.org/10.3390/ijgi11050277 - 27 Apr 2022
Cited by 143 | Viewed by 9161
Abstract
The purpose of our systematic review is to examine the recently published literature on the Internet of Manufacturing Things (IoMT), and integrate the insights it configures on deep learning-assisted smart process planning, robotic wireless sensor networks, and geospatial big data management algorithms by [...] Read more.
The purpose of our systematic review is to examine the recently published literature on the Internet of Manufacturing Things (IoMT), and integrate the insights it configures on deep learning-assisted smart process planning, robotic wireless sensor networks, and geospatial big data management algorithms by employing Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines. Throughout October 2021 and January 2022, a quantitative literature review of aggregators such as ProQuest, Scopus, and the Web of Science was carried out, with search terms including “deep learning-assisted smart process planning + IoMT”, “robotic wireless sensor networks + IoMT”, and “geospatial big data management algorithms + IoMT”. As the analyzed research was published between 2018 and 2022, only 346 sources satisfied the eligibility criteria. A Shiny app was leveraged for the PRISMA flow diagram to comprise evidence-based collected and handled data. Major difficulties and challenges comprised identification of robust correlations among the inspected topics, but focusing on the most recent and relevant sources and deploying screening and quality assessment tools such as the Appraisal Tool for Cross-Sectional Studies, Dedoose, Distiller SR, the Mixed Method Appraisal Tool, and the Systematic Review Data Repository we integrated the core outcomes related to the IoMT. Future research should investigate dynamic scheduling and production execution systems advanced by deep learning-assisted smart process planning, data-driven decision making, and robotic wireless sensor networks. Full article
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24 pages, 1152 KiB  
Review
Artificial Intelligence-Based Decision-Making Algorithms, Internet of Things Sensing Networks, and Deep Learning-Assisted Smart Process Management in Cyber-Physical Production Systems
by Mihai Andronie, George Lăzăroiu, Mariana Iatagan, Cristian Uță, Roxana Ștefănescu and Mădălina Cocoșatu
Electronics 2021, 10(20), 2497; https://doi.org/10.3390/electronics10202497 - 14 Oct 2021
Cited by 201 | Viewed by 16858
Abstract
With growing evidence of deep learning-assisted smart process planning, there is an essential demand for comprehending whether cyber-physical production systems (CPPSs) are adequate in managing complexity and flexibility, configuring the smart factory. In this research, prior findings were cumulated indicating that the interoperability [...] Read more.
With growing evidence of deep learning-assisted smart process planning, there is an essential demand for comprehending whether cyber-physical production systems (CPPSs) are adequate in managing complexity and flexibility, configuring the smart factory. In this research, prior findings were cumulated indicating that the interoperability between Internet of Things-based real-time production logistics and cyber-physical process monitoring systems can decide upon the progression of operations advancing a system to the intended state in CPPSs. We carried out a quantitative literature review of ProQuest, Scopus, and the Web of Science throughout March and August 2021, with search terms including “cyber-physical production systems”, “cyber-physical manufacturing systems”, “smart process manufacturing”, “smart industrial manufacturing processes”, “networked manufacturing systems”, “industrial cyber-physical systems,” “smart industrial production processes”, and “sustainable Internet of Things-based manufacturing systems”. As we analyzed research published between 2017 and 2021, only 489 papers met the eligibility criteria. By removing controversial or unclear findings (scanty/unimportant data), results unsupported by replication, undetailed content, or papers having quite similar titles, we decided on 164, chiefly empirical, sources. Subsequent analyses should develop on real-time sensor networks, so as to configure the importance of artificial intelligence-driven big data analytics by use of cyber-physical production networks. Full article
(This article belongs to the Special Issue Big Data and Artificial Intelligence for Industry 4.0)
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23 pages, 729 KiB  
Review
Sustainable, Smart, and Sensing Technologies for Cyber-Physical Manufacturing Systems: A Systematic Literature Review
by Mihai Andronie, George Lăzăroiu, Roxana Ștefănescu, Cristian Uță and Irina Dijmărescu
Sustainability 2021, 13(10), 5495; https://doi.org/10.3390/su13105495 - 14 May 2021
Cited by 149 | Viewed by 8051
Abstract
With growing evidence of the operational performance of cyber-physical manufacturing systems, there is a pivotal need for comprehending sustainable, smart, and sensing technologies underpinning data-driven decision-making processes. In this research, previous findings were cumulated showing that cyber-physical production networks operate automatically and smoothly [...] Read more.
With growing evidence of the operational performance of cyber-physical manufacturing systems, there is a pivotal need for comprehending sustainable, smart, and sensing technologies underpinning data-driven decision-making processes. In this research, previous findings were cumulated showing that cyber-physical production networks operate automatically and smoothly with artificial intelligence-based decision-making algorithms in a sustainable manner and contribute to the literature by indicating that sustainable Internet of Things-based manufacturing systems function in an automated, robust, and flexible manner. Throughout October 2020 and April 2021, a quantitative literature review of the Web of Science, Scopus, and ProQuest databases was performed, with search terms including “Internet of Things-based real-time production logistics”, “sustainable smart manufacturing”, “cyber-physical production system”, “industrial big data”, “sustainable organizational performance”, “cyber-physical smart manufacturing system”, and “sustainable Internet of Things-based manufacturing system”. As research published between 2018 and 2021 was inspected, and only 426 articles satisfied the eligibility criteria. By taking out controversial or ambiguous findings (insufficient/irrelevant data), outcomes unsubstantiated by replication, too general material, or studies with nearly identical titles, we selected 174 mainly empirical sources. Further developments should entail how cyber-physical production networks and Internet of Things-based real-time production logistics, by use of cognitive decision-making algorithms, enable the advancement of data-driven sustainable smart manufacturing. Full article
(This article belongs to the Special Issue Resilient Cyber-Physical Systems)
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