Search Results (17)

The diversified innovative strategies adopted by the new retail format in urban spaces have significantly driven retail transformation and innovation. The combination of online platforms and physical stores provides a substantial advantage in market competition. This paper takes “Freshippo”, a typical representative of China’s new retail, as an example. Based on multi-source data and using tools such as GIS spatial analysis, statistical analysis, and geographical detectors, this study comprehensively examines the spatial clustering characteristics and influencing factors of Freshippo physical stores in Shanghai. The findings show that Freshippo has significantly expanded in the Shanghai fresh food market by innovatively opening various types of stores. However, there are substantial differences in the proportions of different types of stores, with 94% of the stores having online retail capabilities. Each offline store in the new retail format presents a multi-level “complementary” spatial distribution feature across the urban space, with distinctive clusters in the urban central districts, urban periphery areas, and outer suburban districts. The radiation range of logistics and distribution services exhibits characteristics of “central agglomeration and multi-point distribution”, providing residents with diverse and accurate services. Additionally, the comparison of multiple model results shows that the location selection of various types of new retail stores is significantly influenced by multiple factors, especially the nonlinear amplification effect of factor interactions on store agglomeration. These findings provide an important scientific reference for understanding the development of new retail formats and offer new ideas that promote the transformation and innovation of the retail industry, thereby achieving sustainable development. Full article

The construction of new towns is one of the main measures to evacuate urban populations and promote regional coordination and urban–rural integration in China. Mining the spatio-temporal pattern of new town hot spots based on multivariate data and analyzing the influencing factors of new town construction hot spots can provide a strategic basis for new town construction, but few researchers have extracted and analyzed the influencing factors of new town internal hot spots and their classification. In order to define the key points of Wuhan’s new town construction and promote the construction of new cities in an orderly and efficient manner, this paper first constructs a space-time cube based on the luminous remote sensing data from 2010 to 2019, extracts hot spots and emerging hot spots in Wuhan New City, selects 14 influencing factor indicators such as population density, and uses bivariate Moran’s index to analyze the influencing factors of hot spots, indicating that the number of bus stops and vegetation coverage rate are the most significant. Secondly, the disorderly multivariate logistic regression model is used to analyze the influencing factors of emerging hot spots. The results show that population density, vegetation coverage, road density, distance to water bodies, and distance to train stations are the most significant factors. Finally, based on the analysis results, some relevant suggestions for the construction of Wuhan New City are proposed, providing theoretical support for the planning and policy guidance of new cities, and offering reference for the construction of new towns in other cities, promoting the construction of high-quality cities. Full article

Transcription factors SQUAMOSA Promoter-binding Protein-like (SPL) play a crucial role in regulating plant response to stress, root development, and flower production. However, analysis of SPL gene families in the three rubber-producing plants Taraxacum kok-saghyz, Hevea brasiliensis, and Eucommia ulmoides, renowned for their natural rubber production, has not yet been conducted. In this study, we utilized reference genomes to perform genome-wide analysis, and obtained new insights on the evolution of SPL gene families in these three rubber-producing plants. Our results revealed the following: (1) T. kok-saghyz, H. brasiliensis, and E. ulmoides harbored 25, 16, and 13 SPL genes, respectively, containing conserved structural domains of SBP. (2) A phylogenetic analysis categorized 90 SPL proteins from 25 TkSPLs, 16 HbSPLs, 13 EuSPLs, 17 AtSPLs, and 19 OsSPLs into eight groups. (3) Analysis of cis-acting elements demonstrated that the promoters of EuSPLs contained a significant number of light response elements, hormone regulatory elements, and stress response elements. (4) Transcriptome data analysis revealed that the EuSPL8 gene had strong expression in bark, as well as TkSPL4 and TkSPL8 exhibit high expression levels specifically in roots and latex. This study provides valuable insights into the biological functions of the SPL gene family in the three rubber plants and might serve as a reference for identifying efficient genes. Full article

Parkinson’s disease (PD) can be divided into postural instability and difficult gait (PIGD) and tremor dominance (TD) subtypes. However, potential neural markers located in the dorsal ventral side of the subthalamic nucleus (STN) for delineating the two subtypes of PIGD and TD have not been demonstrated. Therefore, this study aimed to investigate the spectral characteristics of PD on the dorsal ventral side. The differences in the β oscillation spectrum of the spike signal on the dorsal and ventral sides of the STN during deep brain stimulation (DBS) were investigated in 23 patients with PD, and coherence analysis was performed for both subtypes. Finally, each feature was associated with the Unified Parkinson’s Disease Rating Scale (UPDRS). The β power spectral density (PSD) in the dorsal STN was found to be the best predictor of the PD subtype, with 82.6% accuracy. The PSD of dorsal STN β oscillations was greater in the PIGD group than in the TD group (22.17% vs. 18.22%; p < 0.001). Compared with the PIGD group, the TD group showed greater consistency in the β and γ bands. In conclusion, dorsal STN β oscillations could be used as a biomarker to classify PIGD and TD subtypes, guide STN-DBS treatment, and relate to some motor symptoms. Full article

Governmental attention towards the high-quality development of the Yellow River basin has brought new development opportunities for the hotel industry. This study aims to reveal the spatial-temporal evolution patterns and influencing factors of hotels in the Yellow River Basin from 2012 to 2022, based on economic, social, and physical geographic data of 190,000 hotels in the Yellow River flowing. With the help of a GIS technology system, the spatial-temporal evolution patterns of all hotels, star hotels, and ordinary hotels were explored, respectively. Then, the significant influencing factors of these patterns were revealed by using geographic detector and Person correlation analysis. The following conclusions were drawn: (1) the overall scale of the hotel industry in the Yellow River Basin expanded year by year, achieving rapid growth from 2016, and fluctuating around 2020 due to the impact of the novel coronavirus epidemic; the overall spatial distribution had significant regional differences, showing the structural characteristics of “southeast more, northwest less”; (2) there was a great difference in the degree of spatial autocorrelation agglomeration among prefecture-level cities, and the degree of agglomeration of both the hotel industry as a whole and general hotels decreased year by year, showing a random distribution in 2022; star hotels were always distributed randomly. Additionally, a strong synergistic correlation was shown between the number of ordinary hotels and the number of star hotels in local space; (3) overall, the development of the hotel industry was significantly affected by seven factors: structural force, macro force, ecological force, internal power, consumption power, intermediary power, and external power. There were differences in the forces acting on different types of hotels, which gives a pattern recognition in-depth. Full article

Freshippo villages (Hema villages) that develop a typical digital agricultural economy with new retail are distributed in most provinces of China, and the rules of their spatial distribution are important for systemically carrying out current sustainable digital agriculture practices. This paper conducts a study of the spatial distribution of Freshippo villages mainly based on Freshippo data and kernel density estimation, and the results show that Freshippo villages have a spatial cross-regional distribution and form three latitudinal and two longitudinal distribution belts. In particular, there is one main latitudinal distribution belt named the 30° N latitudinal belt and two main longitudinal distribution belts named the eastern coastal longitudinal belt and the longitudinal belt of the Heihe–Tengchong Line. Regionally, several spatial cores formed in the Yangtze River Delta, Shandong, Hubei, and Sichuan. We used linear regression and official provincial statistics to analyze the important relevant factors. Freshippo stores show the highest gradient/y-intercept of 0.2133 and correlation coefficient 0.4599, and all gradient/y-intercepts and correlation coefficients of grain crops are less than those of fruits and vegetables, which reveals that the agricultural product and market are two important factors. In addition, we discuss the spatial effect on agricultural villages under the digitalization of new retail. As the first study of the spatial distribution of Freshippo villages, our paper provides a significant case for the economic geography of digital agriculture. Full article

As a pillar industry carrying China’s ambition in manufacturing upgrades and energy transformation, the new energy vehicle (NEV) industry has received much attention from the government and investment institutions. The spatial pattern of the industry, which is undergoing dramatic changes, urgently needs to be studied retrospectively. This paper explores the spatial distribution pattern of related industries and their influencing factors using data related to NEV industry listed companies from 2008 to 2021. Spatial statistical analysis and stepwise regression analysis were conducted in this study. At the national level, the study found that an “8” industrial axis was formed, with the Yangtze River Delta, the Pearl River Delta, and the Beijing–Tianjin–Hebei city cluster as the core. At the provincial level, it was found that the traditional auto industry-dominant regions do not have a competitive advantage in the NEV field. After stepwise regression of the potential factors, five key factors determining the number of listed NEV enterprises in each province were identified, namely, policy strength, patents, per capita wage, tertiary industry share, and road density. The research results improve the understanding of NEV industry development rules in related disciplines and provide a reference for the spatial arrangement of the NEV industry to be coordinated and optimized at the regional level. Full article

Urban land expansion has dramatically changed the spatial distribution patterns and functional structure of habitats. Previous studies on the spatial externality effect of urban land expansion on the habitat quality of urban agglomerations are still insufficient. With the use of remote sensing and statistical data from 2000 to 2018, this study explored the evolutionary relationship between urban land expansion and habitat quality in the Chengdu-Chongqing urban agglomeration (CUA) using the bivariate local autocorrelation method and spatial Durbin model. Partial differential equation decomposition of the local and spatial spillover effects was implemented to investigate the marginal effects of the influencing factors. The highlights of the results are as follows: CUA’s urban land increased by 2890.42 km² from 2000 to 2018, mainly caused by urban encroachment over farmland and grassland. New urban lands were situated primarily in the main urban districts of Chengdu and Chongqing; urban expansion intensity slowed to 7.64% in 2010–2018, declining by 53.95% from 2000 to 2010. The average habitat quality decreased to 0.905, and two “ring-shaped decline areas” were formed around the main urban areas of Chengdu and Chongqing. “Low-High” and “Low-Low” clusters were the main associations between urban land expansion and habitat quality changes. The impact of urban land expansion on local habitat quality changed from insignificant to negative, while its spatial spillover effects over adjacent areas have increased the negative environmental externalities to habitat quality in adjacent areas through spatial spillovers. Our findings provide evidence for urban agglomerations such as CUA that are still being cultivated to carry out cross-city joint protection strategies of habitat quality, also proving that habitat quality protection should be an integration of urban expansion regulation, natural adaptation and socioeconomic adjustment. Full article

Urban medical facilities are an irreplaceable foundation for ensuring higher levels of public health and medical equity. Hospital accessibility has an extremely important impact on the allocation efficiency and fairness of medical facilities. Although critical, previous studies on accessibility have often overlooked the layout of medical facilities at different levels and the accurate measures of travel time to hospitals, which are both the most critical and fundamental indicators when assessing hospital accessibility. To avoid these pitfalls, this study considers the Shijingshan District, Beijing, China, as an empirical case and proposes an improved potential model based on Web Mapping API (Application Programming Interface) to assess the hospital accessibility of hospitals at different levels during different time periods. Results show that there are significant spatial and temporal differences in hospital accessibility in Shijingshan District, and traffic congestion and the layout of medical facilities are the two most important factors affecting hospital accessibility. This study further improves the hospital accessibility assessment method, with the findings provide a spatial decision support system for urban planners and policymakers regarding optimizing the spatial structure and layout of transportation systems and medical facilities. Full article

(1) Objective: to investigate the association between the total burden of cerebral small vessel disease (CSVD) and cognitive function in Parkinson’s disease (PD). (2) Methods: this retrospective study compared clinical and neuroimaging characteristics of 122 PD patients to determine the association between cognitive decline and total burden of CSVD in PD. All patients underwent brain MRI examinations, and their total CSVD burden scores were evaluated by silent lacunar infarction (SLI), cerebral microbleeds (CMB), white matter hyperintensities (WMH), and enlarged perivascular spaces (EPVS). The cognitive function was assessed by administering Mini-Mental State Examination (MMSE). Receiver-operating characteristic (ROC) curve and the area under the ROC curve (AUC) were performed to quantify the accuracy of the total burden of CSVD and PVH in discriminating PD patients with or without cognitive impairment. (3) Results: the PD patients with cognitive impairment had a significantly higher SLI, CMB, periventricular hyperintensities (PVH), deep white matter hyperintensities (DWMH), enlarged perivascular spaces of basal ganglia (BG-EPVS), and the total CSVD score compared with no cognitive impairment. Total CSVD score and MMSE had a significant negative correlation (r = −0. 483). Furthermore, total burden of CSVD and PVH were the independent risk factors of cognitive impairment in PD, and their good accuracy in discriminating PD patients with cognitive impairment from those with no cognitive impairment was confirmed by the results of ROC curves. (4) Conclusions: total burden of CSVD tightly linked to cognitive impairment in PD patients. The total burden of CSVD or PVH may predict the cognitive impairment in PD. Full article

Deep brain stimulation (DBS) is an effective treatment for dyskinesia in patients with Parkinson’s disease (PD), among which the therapeutic targets commonly used include the subthalamic nucleus (STN) and the globus pallidus internus (GPi). Levodopa-induced dyskinesia (LID) is one of the common motor complications arising in PD patients on chronic treatment with levodopa. In this article, we retrospectively evaluated the outcomes of LID with the Unified Dyskinesia Rating Scale (UDysRS) in patients who underwent DBS in multiple centers with a GPi or an STN target. Meanwhile, the Med off MDS-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS-Ⅲ) and the levodopa equivalent daily dose (LEDD) were also observed as secondary indicators. PD patients with a GPi target showed a more significant improvement in the UDysRS compared with an STN target (92.9 ± 16.7% vs. 66.0 ± 33.6%, p < 0.0001). Both the GPi and the STN showed similar improvement in Med off UPDRS-III scores (49.8 ± 22.6% vs. 52.3 ± 29.5%, p = 0.5458). However, the LEDD was obviously reduced with the STN target compared with the GPi target (44.6 ± 28.1% vs. 12.2 ± 45.8%, p = 0.006). Full article

The hospital accessibility of Acute Myocardial Infarction (AMI) emergency treatment is of great importance, not only for improving the survival rate of patients but also for protecting the basic human right to health care. Traditional AMI emergency treatment research often does not consider ways to shorten the travel time to hospitals for AMI patients and does not reflect the actual time it takes to travel to hospitals, which is critical to AMI emergency treatment. To avoid these shortcomings, this study proposes a method of accessibility measurement based on Web Mapping API (Application Programming Interface) to obtain travel time to hospitals during different periods, then calculated the AMI hospital accessibility based on these detailed data. This study considered the Shijingshan District, Beijing, China, as an empirical case. The study discovered significant differences in the temporal and spatial characteristics of the AMI hospital accessibility on weekdays and weekends. The analysis revealed that travel time to hospitals and traffic congestion are the two main factors affecting AMI hospital accessibility. The research results shed new light on the accessibility of urban medical facilities and provide a scientific basis with which local governments can optimize the spatial structure of medical facilities. Full article

The Chengdu-Chongqing urban agglomeration (CUA) faces considerable air quality concerns, although the situation has improved in the past 15 years. The driving effects of population, land and economic urbanization on PM_2.5 concentrations in the CUA have largely been overlooked in previous studies. The contributions of natural and socio-economic factors to PM_2.5 concentrations have been ignored and the spillover effects of multi-dimensional urbanization on PM_2.5 concentrations have been underestimated. This study explores the spatial dependence and trend evolution of PM_2.5 concentrations in the CUA at the grid and county level, analyzing the direct and spillover effects of multi-dimensional urbanization on PM_2.5 concentrations. The results show that the mean PM_2.5 concentrations in CUA dropped to 48.05 μg/m³ at an average annual rate of 4.6% from 2000 to 2015; however, in 2015, there were still 91% of areas exposed to pollution risk (>35 μg/m³). The PM_2.5 concentrations in 92.98% of the area have slowly decreased but are rising in some areas, such as Shimian County, Xuyong County and Gulin County. The PM_2.5 concentrations in this region presented a spatial dependence pattern of “cold spots in the east and hot spots in the west”. Urbanization was not the only factor contributing to PM_2.5 concentrations. Commercial trade, building development and atmospheric pressure were found to have significant contributions. The spillover effect of multi-dimensional urbanization was found to be generally stronger than the direct effects and the positive impact of land urbanization on PM_2.5 concentrations was stronger than population and economic urbanization. The findings provide support for urban agglomerations such as CUA that are still being cultivated to carry out cross-city joint control strategies of PM_2.5 concentrations, also proving that PM_2.5 pollution control should not only focus on urban socio-economic development strategies but should be an integration of work optimization in various areas such as population agglomeration, land expansion, economic construction, natural adaptation and socio-economic adjustment. Full article

The Dongsha Shoal is one of the largest shoals in the South Yellow Sea and has important marine ecological value. The shoal extends in a south–north direction and is controlled by the regional dominating tidal currents. Recently, due to human activities and some natural factors, the geomorphic dynamics of the Dongsha Shoal has undergone drastic changes. However, few people have proposed quantitative research on the changes of tidal flat morphology, let alone the long-term sequence analysis of sand ridge lines. Hence, we attempt to take the Dongsha Shoal in the Radial Sand Ridges as the research area, and analyze the trends of the long-term morphological evolution of the sand ridge lines over the period 1973–2016 based on a high-density time series of medium-resolution satellite images. The sand ridge line generally moves from southeast to northwest, and the position distribution of the sand ridge line from north to south has gradually changed from compact to scattered. We also found that the geomorphological dynamics at different positions of the sand ridge line are inconsistent. The north and south wings are eroded on the west side, while the central area is eroded on the east side. Most of the sand ridge line is moving eastward. In addition, the change of sand ridge line is affected by multiple factors such as sediment supply, typhoon, reclamation and laver cultivation. Full article

Africa has been experiencing a rapid urbanization process, which may lead to an increase in unsustainable land use and urban poverty. Assessing the spatiotemporal characteristics of urbanization dynamics is especially important and needed for the sustainable development of Africa. Satellite-based nighttime light (NTL) data are widely used to monitor the dynamics of urban growth from global to local scales. In this study, urban growth patterns across Africa were analyzed and discussed using stable nighttime light datasets obtained from DMSP/OLS (the Defense Meteorological Satellite Program’s Operational Line-scan System) spanning from 1992 to 2013. We partitioned the nighttime lighting areas into three types (low, medium, and high) using thresholds derived from the Brightness Gradient (BG) method. Our results indicated that built-up areas in Africa have increased rapidly, particularly those areas with low nighttime lighting types. Countries with higher urbanization levels in Africa, like South Africa, Algeria, Egypt, Nigeria, and Libya, were leading the brightening trend. The distribution of nighttime lighting types was consistent with the characteristics of urban development, with high nighttime lighting types showed up at the urban center, whereas medium and low nighttime lighting types appeared in the urban-rural transition zone and rural areas respectively. The impacts of these findings on the future of African cities will be further proposed. Full article