Search Results (31)

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by difficulties in social communication and repetitive behaviors. The exact causes of ASD remain elusive and likely involve a combination of genetic, environmental, and neurobiological factors. Doctors often face challenges in accurately identifying ASD early due to its complex and diverse presentation. Early detection and intervention are crucial for improving outcomes for individuals with ASD. Early diagnosis allows for timely access to appropriate interventions, leading to better social and communication skills development. Artificial intelligence techniques, particularly facial feature extraction using machine learning algorithms, display promise in aiding the early detection of ASD. By analyzing facial expressions and subtle cues, AI models identify patterns associated with ASD features. This study developed various hybrid systems to diagnose facial feature images for an ASD dataset by combining convolutional neural network (CNN) features. The first approach utilized pre-trained VGG16, ResNet101, and MobileNet models. The second approach employed a hybrid technique that combined CNN models (VGG16, ResNet101, and MobileNet) with XGBoost and RF algorithms. The third strategy involved diagnosing ASD using XGBoost and an RF based on features of VGG-16-ResNet101, ResNet101-MobileNet, and VGG16-MobileNet models. Notably, the hybrid RF algorithm that utilized features from the VGG16-MobileNet models demonstrated superior performance, reached an AUC of 99.25%, an accuracy of 98.8%, a precision of 98.9%, a sensitivity of 99%, and a specificity of 99.1%. Full article

Diabetic retinopathy (DR) is a complication of diabetes that damages the delicate blood vessels of the retina and leads to blindness. Ophthalmologists rely on diagnosing the retina by imaging the fundus. The process takes a long time and needs skilled doctors to diagnose and determine the stage of DR. Therefore, automatic techniques using artificial intelligence play an important role in analyzing fundus images for the detection of the stages of DR development. However, diagnosis using artificial intelligence techniques is a difficult task and passes through many stages, and the extraction of representative features is important in reaching satisfactory results. Convolutional Neural Network (CNN) models play an important and distinct role in extracting features with high accuracy. In this study, fundus images were used for the detection of the developmental stages of DR by two proposed methods, each with two systems. The first proposed method uses GoogLeNet with SVM and ResNet-18 with SVM. The second method uses Feed-Forward Neural Networks (FFNN) based on the hybrid features extracted by first using GoogLeNet, Fuzzy color histogram (FCH), Gray Level Co-occurrence Matrix (GLCM), and Local Binary Pattern (LBP); followed by ResNet-18, FCH, GLCM and LBP. All the proposed methods obtained superior results. The FFNN network with hybrid features of ResNet-18, FCH, GLCM, and LBP obtained 99.7% accuracy, 99.6% precision, 99.6% sensitivity, 100% specificity, and 99.86% AUC. Full article

Cervical cancer is one of the most common types of malignant tumors in women. In addition, it causes death in the latter stages. Squamous cell carcinoma is the most common and aggressive form of cervical cancer and must be diagnosed early before it progresses to a dangerous stage. Liquid-based cytology (LBC) swabs are best and most commonly used for cervical cancer screening and are converted from glass slides to whole-slide images (WSIs) for computer-assisted analysis. Manual diagnosis by microscopes is limited and prone to manual errors, and tracking all cells is difficult. Therefore, the development of computational techniques is important as diagnosing many samples can be done automatically, quickly, and efficiently, which is beneficial for medical laboratories and medical professionals. This study aims to develop automated WSI image analysis models for early diagnosis of a cervical squamous cell dataset. Several systems have been designed to analyze WSI images and accurately distinguish cervical cancer progression. For all proposed systems, the WSI images were optimized to show the contrast of edges of the low-contrast cells. Then, the cells to be analyzed were segmented and isolated from the rest of the image using the Active Contour Algorithm (ACA). WSI images were diagnosed by a hybrid method between deep learning (ResNet50, VGG19 and GoogLeNet), Random Forest (RF), and Support Vector Machine (SVM) algorithms based on the ACA algorithm. Another hybrid method for diagnosing WSI images by RF and SVM algorithms is based on fused features of deep-learning (DL) models (ResNet50-VGG19, VGG19-GoogLeNet, and ResNet50-GoogLeNet). It is concluded from the systems’ performance that the DL models’ combined features help significantly improve the performance of the RF and SVM networks. The novelty of this research is the hybrid method that combines the features extracted from deep-learning models (ResNet50-VGG19, VGG19-GoogLeNet, and ResNet50-GoogLeNet) with RF and SVM algorithms for diagnosing WSI images. The results demonstrate that the combined features from deep-learning models significantly improve the performance of RF and SVM. The RF network with fused features of ResNet50-VGG19 achieved an AUC of 98.75%, a sensitivity of 97.4%, an accuracy of 99%, a precision of 99.6%, and a specificity of 99.2%. Full article

Malignant lymphoma is one of the most severe types of disease that leads to death as a result of exposure of lymphocytes to malignant tumors. The transformation of cells from indolent B-cell lymphoma to B-cell lymphoma (DBCL) is life-threatening. Biopsies taken from the patient are the gold standard for lymphoma analysis. Glass slides under a microscope are converted into whole slide images (WSI) to be analyzed by AI techniques through biomedical image processing. Because of the multiplicity of types of malignant lymphomas, manual diagnosis by pathologists is difficult, tedious, and subject to disagreement among physicians. The importance of artificial intelligence (AI) in the early diagnosis of malignant lymphoma is significant and has revolutionized the field of oncology. The use of AI in the early diagnosis of malignant lymphoma offers numerous benefits, including improved accuracy, faster diagnosis, and risk stratification. This study developed several strategies based on hybrid systems to analyze histopathological images of malignant lymphomas. For all proposed models, the images and extraction of malignant lymphocytes were optimized by the gradient vector flow (GVF) algorithm. The first strategy for diagnosing malignant lymphoma images relied on a hybrid system between three types of deep learning (DL) networks, XGBoost algorithms, and decision tree (DT) algorithms based on the GVF algorithm. The second strategy for diagnosing malignant lymphoma images was based on fusing the features of the MobileNet-VGG16, VGG16-AlexNet, and MobileNet-AlexNet models and classifying them by XGBoost and DT algorithms based on the ant colony optimization (ACO) algorithm. The color, shape, and texture features, which are called handcrafted features, were extracted by four traditional feature extraction algorithms. Because of the similarity in the biological characteristics of early-stage malignant lymphomas, the features of the fused MobileNet-VGG16, VGG16-AlexNet, and MobileNet-AlexNet models were combined with the handcrafted features and classified by the XGBoost and DT algorithms based on the ACO algorithm. We concluded that the performance of the two networks XGBoost and DT, with fused features between DL networks and handcrafted, achieved the best performance. The XGBoost network based on the fused features of MobileNet-VGG16 and handcrafted features resulted in an AUC of 99.43%, accuracy of 99.8%, precision of 99.77%, sensitivity of 99.7%, and specificity of 99.8%. This highlights the significant role of AI in the early diagnosis of malignant lymphoma, offering improved accuracy, expedited diagnosis, and enhanced risk stratification. This study highlights leveraging AI techniques and biomedical image processing; the analysis of whole slide images (WSI) converted from biopsies allows for improved accuracy, faster diagnosis, and risk stratification. The developed strategies based on hybrid systems, combining deep learning networks, XGBoost and decision tree algorithms, demonstrated promising results in diagnosing malignant lymphoma images. Furthermore, the fusion of handcrafted features with features extracted from DL networks enhanced the performance of the classification models. Full article

Epilepsy is a neurological disorder in the activity of brain cells that leads to seizures. An electroencephalogram (EEG) can detect seizures as it contains physiological information of the neural activity of the brain. However, visual examination of EEG by experts is time consuming, and their diagnoses may even contradict each other. Thus, an automated computer-aided diagnosis for EEG diagnostics is necessary. Therefore, this paper proposes an effective approach for the early detection of epilepsy. The proposed approach involves the extraction of important features and classification. First, signal components are decomposed to extract the features via the discrete wavelet transform (DWT) method. Principal component analysis (PCA) and the t-distributed stochastic neighbor embedding (t-SNE) algorithm were applied to reduce the dimensions and focus on the most important features. Subsequently, K-means clustering + PCA and K-means clustering + t-SNE were used to divide the dataset into subgroups to reduce the dimensions and focus on the most important representative features of epilepsy. The features extracted from these steps were fed to extreme gradient boosting, K-nearest neighbors (K-NN), decision tree (DT), random forest (RF) and multilayer perceptron (MLP) classifiers. The experimental results demonstrated that the proposed approach provides superior results to those of existing studies. During the testing phase, the RF classifier with DWT and PCA achieved an accuracy of 97.96%, precision of 99.1%, recall of 94.41% and F1 score of 97.41%. Moreover, the RF classifier with DWT and t-SNE attained an accuracy of 98.09%, precision of 99.1%, recall of 93.9% and F1 score of 96.21%. In comparison, the MLP classifier with PCA + K-means reached an accuracy of 98.98%, precision of 99.16%, recall of 95.69% and F1 score of 97.4%. Full article

Parkinson’s disease (PD) is a neurodegenerative condition generated by the dysfunction of brain cells and their 60–80% inability to produce dopamine, an organic chemical responsible for controlling a person’s movement. This condition causes PD symptoms to appear. Diagnosis involves many physical and psychological tests and specialist examinations of the patient’s nervous system, which causes several issues. The methodology method of early diagnosis of PD is based on analysing voice disorders. This method extracts a set of features from a recording of the person’s voice. Then machine-learning (ML) methods are used to analyse and diagnose the recorded voice to distinguish Parkinson’s cases from healthy ones. This paper proposes novel techniques to optimize the techniques for early diagnosis of PD by evaluating selected features and hyperparameter tuning of ML algorithms for diagnosing PD based on voice disorders. The dataset was balanced by the synthetic minority oversampling technique (SMOTE) and features were arranged according to their contribution to the target characteristic by the recursive feature elimination (RFE) algorithm. We applied two algorithms, t-distributed stochastic neighbour embedding (t-SNE) and principal component analysis (PCA), to reduce the dimensions of the dataset. Both t-SNE and PCA finally fed the resulting features into the classifiers support-vector machine (SVM), K-nearest neighbours (KNN), decision tree (DT), random forest (RF), and multilayer perception (MLP). Experimental results proved that the proposed techniques were superior to existing studies in which RF with the t-SNE algorithm yielded an accuracy of 97%, precision of 96.50%, recall of 94%, and F1-score of 95%. In addition, MLP with the PCA algorithm yielded an accuracy of 98%, precision of 97.66%, recall of 96%, and F1-score of 96.66%. Full article

White blood cells (WBCs) are one of the main components of blood produced by the bone marrow. WBCs are part of the immune system that protects the body from infectious diseases and an increase or decrease in the amount of any type that causes a particular disease. Thus, recognizing the WBC types is essential for diagnosing the patient’s health and identifying the disease. Analyzing blood samples to determine the amount and WBC types requires experienced doctors. Artificial intelligence techniques were applied to analyze blood samples and classify their types to help doctors distinguish between types of infectious diseases due to increased or decreased WBC amounts. This study developed strategies for analyzing blood slide images to classify WBC types. The first strategy is to classify WBC types by the SVM-CNN technique. The second strategy for classifying WBC types is by SVM based on hybrid CNN features, which are called VGG19-ResNet101-SVM, ResNet101-MobileNet-SVM, and VGG19-ResNet101-MobileNet-SVM techniques. The third strategy for classifying WBC types by FFNN is based on a hybrid model of CNN and handcrafted features. With MobileNet and handcrafted features, FFNN achieved an AUC of 99.43%, accuracy of 99.80%, precision of 99.75%, specificity of 99.75%, and sensitivity of 99.68%. Full article

Breast cancer is the second most common type of cancer among women, and it can threaten women’s lives if it is not diagnosed early. There are many methods for detecting breast cancer, but they cannot distinguish between benign and malignant tumors. Therefore, a biopsy taken from the patient’s abnormal tissue is an effective way to distinguish between malignant and benign breast cancer tumors. There are many challenges facing pathologists and experts in diagnosing breast cancer, including the addition of some medical fluids of various colors, the direction of the sample, the small number of doctors and their differing opinions. Thus, artificial intelligence techniques solve these challenges and help clinicians resolve their diagnostic differences. In this study, three techniques, each with three systems, were developed to diagnose multi and binary classes of breast cancer datasets and distinguish between benign and malignant types with 40× and 400× factors. The first technique for diagnosing a breast cancer dataset is using an artificial neural network (ANN) with selected features from VGG-19 and ResNet-18. The second technique for diagnosing breast cancer dataset is by ANN with combined features for VGG-19 and ResNet-18 before and after principal component analysis (PCA). The third technique for analyzing breast cancer dataset is by ANN with hybrid features. The hybrid features are a hybrid between VGG-19 and handcrafted; and a hybrid between ResNet-18 and handcrafted. The handcrafted features are mixed features extracted using Fuzzy color histogram (FCH), local binary pattern (LBP), discrete wavelet transform (DWT) and gray level co-occurrence matrix (GLCM) methods. With the multi classes data set, ANN with the hybrid features of the VGG-19 and handcrafted reached a precision of 95.86%, an accuracy of 97.3%, sensitivity of 96.75%, AUC of 99.37%, and specificity of 99.81% with images at magnification factor 400×. Whereas with the binary classes data set, ANN with the hybrid features of the VGG-19 and handcrafted reached a precision of 99.74%, an accuracy of 99.7%, sensitivity of 100%, AUC of 99.85%, and specificity of 100% with images at a magnification factor 400×. Full article

The gastrointestinal system contains the upper and lower gastrointestinal tracts. The main tasks of the gastrointestinal system are to break down food and convert it into essential elements that the body can benefit from and expel waste in the form of feces. If any organ is affected, it does not work well, which affects the body. Many gastrointestinal diseases, such as infections, ulcers, and benign and malignant tumors, threaten human life. Endoscopy techniques are the gold standard for detecting infected parts within the organs of the gastrointestinal tract. Endoscopy techniques produce videos that are converted into thousands of frames that show the disease’s characteristics in only some frames. Therefore, this represents a challenge for doctors because it is a tedious task that requires time, effort, and experience. Computer-assisted automated diagnostic techniques help achieve effective diagnosis to help doctors identify the disease and give the patient the appropriate treatment. In this study, many efficient methodologies for analyzing endoscopy images for diagnosing gastrointestinal diseases were developed for the Kvasir dataset. The Kvasir dataset was classified by three pre-trained models: GoogLeNet, MobileNet, and DenseNet121. The images were optimized, and the gradient vector flow (GVF) algorithm was applied to segment the regions of interest (ROIs), isolating them from healthy regions and saving the endoscopy images as Kvasir-ROI. The Kvasir-ROI dataset was classified by the three pre-trained GoogLeNet, MobileNet, and DenseNet121 models. Hybrid methodologies (CNN–FFNN and CNN–XGBoost) were developed based on the GVF algorithm and achieved promising results for diagnosing disease based on endoscopy images of gastroenterology. The last methodology is based on fused CNN models and their classification by FFNN and XGBoost networks. The hybrid methodology based on the fused CNN features, called GoogLeNet–MobileNet–DenseNet121–XGBoost, achieved an AUC of 97.54%, accuracy of 97.25%, sensitivity of 96.86%, precision of 97.25%, and specificity of 99.48%. Full article

Early detection of eye diseases is the only solution to receive timely treatment and prevent blindness. Colour fundus photography (CFP) is an effective fundus examination technique. Because of the similarity in the symptoms of eye diseases in the early stages and the difficulty in distinguishing between the type of disease, there is a need for computer-assisted automated diagnostic techniques. This study focuses on classifying an eye disease dataset using hybrid techniques based on feature extraction with fusion methods. Three strategies were designed to classify CFP images for the diagnosis of eye disease. The first method is to classify an eye disease dataset using an Artificial Neural Network (ANN) with features from the MobileNet and DenseNet121 models separately after reducing the high dimensionality and repetitive features using Principal Component Analysis (PCA). The second method is to classify the eye disease dataset using an ANN on the basis of fused features from the MobileNet and DenseNet121 models before and after reducing features. The third method is to classify the eye disease dataset using ANN based on the fused features from the MobileNet and DenseNet121 models separately with handcrafted features. Based on the fused MobileNet and handcrafted features, the ANN attained an AUC of 99.23%, an accuracy of 98.5%, a precision of 98.45%, a specificity of 99.4%, and a sensitivity of 98.75%. Full article

Alzheimer’s disease (AD) is considered one of the challenges facing health care in the modern century; until now, there has been no effective treatment to cure it, but there are drugs to slow its progression. Therefore, early detection of Alzheimer’s is vital to take needful measures before it develops into brain damage which cannot be treated. Magnetic resonance imaging (MRI) techniques have contributed to the diagnosis and prediction of its progression. MRI images require highly experienced doctors and radiologists, and the analysis of MRI images takes time to analyze each slice. Thus, deep learning techniques play a vital role in analyzing a huge amount of MRI images with high accuracy to detect Alzheimer’s and predict its progression. Because of the similarities in the characteristics of the early stages of Alzheimer’s, this study aimed to extract the features in several methods and integrate the features extracted from more than one method into the same features matrix. This study contributed to the development of three methodologies, each with two systems, with all systems aimed at achieving satisfactory accuracy for the detection of AD and predicting the stages of its progression. The first methodology is by Feed Forward Neural Network (FFNN) with the features of GoogLeNet and DenseNet-121 models separately. The second methodology is by FFNN network with combined features between GoogLeNet and Dense-121 models before and after high-dimensionality reduction of features using the Principal Component Analysis (PCA) algorithm. The third methodology is by FFNN network with combined features between GoogLeNet and Dense-121 models separately and features extracted by Discrete Wavelet Transform (DWT), Local Binary Pattern (LBP) and Gray Level Co-occurrence Matrix (GLCM) methods called handcrafted features. All systems yielded super results in detecting AD and predicting the stages of its progression. With the combined features of the DenseNet-121 and handcrafted, the FFNN achieved an accuracy of 99.7%, sensitivity of 99.64%, AUC of 99.56%, precision of 99.63%, and a specificity of 99.67%. Full article

Knee osteoarthritis (KOA) is a chronic disease that impedes movement, especially in the elderly, affecting more than 5% of people worldwide. KOA goes through many stages, from the mild grade that can be treated to the severe grade in which the knee must be replaced. Therefore, early diagnosis of KOA is essential to avoid its development to the advanced stages. X-rays are one of the vital techniques for the early detection of knee infections, which requires highly experienced doctors and radiologists to distinguish Kellgren-Lawrence (KL) grading. Thus, artificial intelligence techniques solve the shortcomings of manual diagnosis. This study developed three methodologies for the X-ray analysis of both the Osteoporosis Initiative (OAI) and Rani Channamma University (RCU) datasets for diagnosing KOA and discrimination between KL grades. In all methodologies, the Principal Component Analysis (PCA) algorithm was applied after the CNN models to delete the unimportant and redundant features and keep the essential features. The first methodology for analyzing x-rays and diagnosing the degree of knee inflammation uses the VGG-19 -FFNN and ResNet-101 -FFNN systems. The second methodology of X-ray analysis and diagnosis of KOA grade by Feed Forward Neural Network (FFNN) is based on the combined features of VGG-19 and ResNet-101 before and after PCA. The third methodology for X-ray analysis and diagnosis of KOA grade by FFNN is based on the fusion features of VGG-19 and handcrafted features, and fusion features of ResNet-101 and handcrafted features. For an OAI dataset with fusion features of VGG-19 and handcrafted features, FFNN obtained an AUC of 99.25%, an accuracy of 99.1%, a sensitivity of 98.81%, a specificity of 100%, and a precision of 98.24%. For the RCU dataset with the fusion features of VGG-19 and the handcrafted features, FFNN obtained an AUC of 99.07%, an accuracy of 98.20%, a sensitivity of 98.16%, a specificity of 99.73%, and a precision of 98.08%. Full article

The immune system is one of the most critical systems in humans that resists all diseases and protects the body from viruses, bacteria, etc. White blood cells (WBCs) play an essential role in the immune system. To diagnose blood diseases, doctors analyze blood samples to characterize the features of WBCs. The characteristics of WBCs are determined based on the chromatic, geometric, and textural characteristics of the WBC nucleus. Manual diagnosis is subject to many errors and differing opinions of experts and takes a long time; however, artificial intelligence techniques can help to solve all these challenges. Determining the type of WBC using automatic diagnosis helps hematologists to identify different types of blood diseases. This work aims to overcome manual diagnosis by developing automated systems for classifying microscopic blood sample datasets for the early detection of diseases in WBCs. Several proposed systems were used: first, neural network algorithms, such as artificial neural networks (ANNs) and feed-forward neural networks (FFNNs), were applied to diagnose the dataset based on the features extracted using the hybrid method between two algorithms, the local binary pattern (LBP) and gray-level co-occurrence matrix (GLCM). All algorithms attained superior accuracy for WBC diagnosis. Second, the pre-trained convolutional neural network (CNN) models AlexNet, ResNet-50, GoogLeNet, and ResNet-18 were applied for the early detection of WBC diseases. All models attained exceptional results in the early detection of WBC diseases. Third, the hybrid technique was applied, consisting of a pair of blocks: the CNN models block for extracting deep features and the SVM algorithm block for the classification of deep features with superior accuracy and efficiency. These hybrid techniques are named AlexNet with SVM, ResNet-50 with SVM, GoogLeNet with SVM, and ResNet-18 with SVM. All techniques achieved promising results when diagnosing the dataset for the early detection of WBC diseases. The ResNet-50 model achieved an accuracy of 99.3%, a precision of 99.5%, a sensitivity of 99.25%, a specificity of 99.75%, and an AUC of 99.99%. Full article

Melanoma is one of the deadliest types of skin cancer that leads to death if not diagnosed early. Many skin lesions are similar in the early stages, which causes an inaccurate diagnosis. Accurate diagnosis of the types of skin lesions helps dermatologists save patients’ lives. In this paper, we propose hybrid systems based on the advantages of fused CNN models. CNN models receive dermoscopy images of the ISIC 2019 dataset after segmenting the area of lesions and isolating them from healthy skin through the Geometric Active Contour (GAC) algorithm. Artificial neural network (ANN) and Random Forest (Rf) receive fused CNN features and classify them with high accuracy. The first methodology involved analyzing the area of skin lesions and diagnosing their type early using the hybrid models CNN-ANN and CNN-RF. CNN models (AlexNet, GoogLeNet and VGG16) receive lesions area only and produce high depth feature maps. Thus, the deep feature maps were reduced by the PCA and then classified by ANN and RF networks. The second methodology involved analyzing the area of skin lesions and diagnosing their type early using the hybrid CNN-ANN and CNN-RF models based on the features of the fused CNN models. It is worth noting that the features of the CNN models were serially integrated after reducing their high dimensions by Principal Component Analysis (PCA). Hybrid models based on fused CNN features achieved promising results for diagnosing dermatoscopic images of the ISIC 2019 data set and distinguishing skin cancer from other skin lesions. The AlexNet-GoogLeNet-VGG16-ANN hybrid model achieved an AUC of 94.41%, sensitivity of 88.90%, accuracy of 96.10%, precision of 88.69%, and specificity of 99.44%. Full article

Lung and colon cancer are among humanity’s most common and deadly cancers. In 2020, there were 4.19 million people diagnosed with lung and colon cancer, and more than 2.7 million died worldwide. Some people develop lung and colon cancer simultaneously due to smoking which causes lung cancer, leading to an abnormal diet, which also causes colon cancer. There are many techniques for diagnosing lung and colon cancer, most notably the biopsy technique and its analysis in laboratories. Due to the scarcity of health centers and medical staff, especially in developing countries. Moreover, manual diagnosis takes a long time and is subject to differing opinions of doctors. Thus, artificial intelligence techniques solve these challenges. In this study, three strategies were developed, each with two systems for early diagnosis of histological images of the LC25000 dataset. Histological images have been improved, and the contrast of affected areas has been increased. The GoogLeNet and VGG-19 models of all systems produced high dimensional features, so redundant and unnecessary features were removed to reduce high dimensionality and retain essential features by the PCA method. The first strategy for diagnosing the histological images of the LC25000 dataset by ANN uses crucial features of GoogLeNet and VGG-19 models separately. The second strategy uses ANN with the combined features of GoogLeNet and VGG-19. One system reduced dimensions and combined, while the other combined high features and then reduced high dimensions. The third strategy uses ANN with fusion features of CNN models (GoogLeNet and VGG-19) and handcrafted features. With the fusion features of VGG-19 and handcrafted features, the ANN reached a sensitivity of 99.85%, a precision of 100%, an accuracy of 99.64%, a specificity of 100%, and an AUC of 99.86%. Full article