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TropicalMed
Special Issues
Insecticide and Antimalarial Resistance Markers
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Insecticide and Antimalarial Resistance Markers

A special issue of Tropical Medicine and Infectious Disease (ISSN 2414-6366). This special issue belongs to the section "Vector-Borne Diseases".

Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 4284

Special Issue Editor

Dr. Sulaiman S. Ibrahim

E-Mail Website
Guest Editor
1. Post-Doctoral Research Associate (PDRA), Vector Biology Department, Liverpool School of Tropical Medicine (LSTM), Liverpool L3 5QA, UK
2. Department of Biochemistry, Bayero University, Kano PMB 3011, Nigeria
3. Centre for Research in Infectious Diseases (CRID), Yaoundé P.O. Box 13591, Cameroon
Interests: mosquito; vectors; Anopheles; malaria; insecticides; resistance; Plasmodium; antimalarial; genes; functional genomics; transcriptomics; transgenesis; agricultural pests; pesticides
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Malaria is one of the major diseases affecting millions of people around the world, with ~400,000 deaths globally—more than 90% of these in sub-Saharan Africa.

Malaria control relies heavily on a two-pronged approach: the combination of malaria vector control and chemotherapy against Plasmodium. However, the escalation in insecticide resistance in the malaria vectors and widespread antimalarial resistance in the Plasmodium which is reported across the world is threatening to derail malaria control, with the progress stalling in recent years. Populations of mosquitoes have become highly resistant to the ingredients (especially the pyrethroids which are the most widely used chemicals) in use for the impregnation of long-lasting insecticidal nets (LLINs) and indoor residual spraying. The failure of antimalarials has become disproportionately high, including cases of artemisinin resistance, the component of front-line treatment, the ACTs. Resistance is also confounded by the high heterogeneity in its molecular basis—for example, ACT resistance across Africa despite the absence of the major mutations in the kelch13 gene validated/known to drive/delay parasite clearance. The detection and validation of metabolic and target-site insensitivity resistance markers aid the early detection of resistance alleles, allow tracking of their evolution in the field, and facilitate evidence-based control and resistance-management strategies by stakeholders and National Malaria Control Programs. This Special Issue will showcase research efforts to detect and validate known insecticides and/or antimalarial resistance markers, as well as discovery and validation of novel markers of resistance. Suitable manuscripts will preferably cover: the distribution and resistance profiles of the major malaria vectors across different regions of the world; the distribution and resistance profiles of the various genotypes of Plasmodium across different regions of the world; insecticide resistance surveillance; antimalarial resistance surveillance; known and novel insecticide resistance markers; known and novel antimalarial resistance markers; genetic diversity and spread of resistance markers; and the operational impact of resistance markers on malaria control.       

Dr. Sulaiman S Ibrahim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Tropical Medicine and Infectious Disease is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Malaria
  • Anopheles
  • Plasmodium
  • Resistance
  • Markers
  • Control

Published Papers (1 paper)

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Research

14 pages, 1308 KiB  
Article
Genetic Diversity of Human Host Genes Involved in Immune Response and the Binding of Malaria Parasite in Patients Residing along the Thai-Myanmar border
by Kridsada Sirisabhabhorn, Wanna Chaijaroenkul and Kesara Na-Bangchang
Trop. Med. Infect. Dis. 2021, 6(4), 174; https://doi.org/10.3390/tropicalmed6040174 - 24 Sep 2021
Cited by 2 | Viewed by 2858
Abstract
Polymorphisms of the genes encoding proteins involved in immune functions and the binding of malaria parasites to human host cells have been the focus of research in recent years, aiming to understand malaria pathogenesis and case severity and to exploit this knowledge to [...] Read more.
Polymorphisms of the genes encoding proteins involved in immune functions and the binding of malaria parasites to human host cells have been the focus of research in recent years, aiming to understand malaria pathogenesis and case severity and to exploit this knowledge to assert control over malaria. This study investigated the genetic diversity of the human host genes encoding proteins that are involved in immune functions and malaria parasite binding, i.e., MCP1 (−2518), TGFβ1 (−509), TNFα (−308), IL4 (VNTR), IL6 (−174), IL10 (−3575), TLR4 (299), CD36 (−188), and ICAM1 (469) in patients with mono-infection of Plasmodium falciparum and Plasmodium vivax infections in the multidrug-resistant areas along the Thai-Myanmar border. The association between gene polymorphisms and parasite density was also investigated. Genomic DNA (gDNA) of P. falciparum and P. vivax were extracted from whole blood and dried blood spot (DBS). Gene amplification and genotyping were performed by PCR and PCR-RFLP analysis, respectively. Of these samples, 178 and 209 samples were, respectively, mono-infection with P. falciparum and P. vivax. The ratio of P. falciparum: P. vivax was 46%:54%. Results showed marked variation in the frequency distribution and patterns of the genotypes and gene alleles of the nine immune response genes or human host genes. The SNPs of TGFβ1, IL10 and ICAM1, were significantly associated with P. falciparum, but not P. vivax parasite density. TGFβ1, IL10 and ICAM1, may play more significant roles in modulating P. falciparum than P. vivax parasitemia. The prevalence of the genotypes and gene alleles of these genes, including their association with parasite density, may vary depending on patient ethnicity and endemic areas. Information obtained from each endemic area is essential for treatment strategies and the development of vaccines for malaria prophylaxis in specific areas. Full article
(This article belongs to the Special Issue Insecticide and Antimalarial Resistance Markers)
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