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TropicalMed
Special Issues
Research Advances and New Perspectives on Helminthic Diseases
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Research Advances and New Perspectives on Helminthic Diseases

A special issue of Tropical Medicine and Infectious Disease (ISSN 2414-6366). This special issue belongs to the section "Infectious Diseases".

Deadline for manuscript submissions: 31 July 2026 | Viewed by 1205

Special Issue Editors

Dr. James Lee Crainey

E-Mail Website
Guest Editor
Laboratory of Infectious Disease Ecology in the Amazon, Oswaldo Cruz Foundation, Instituto Leônidas e Maria Deane, Manaus 69057, Brazil
Interests: helminths; filarial parasites; molecular eco-epidemiology; neglected disease vectors (NDVs)
Prof. Dr. Susana Vaz Nery

E-Mail Website
Guest Editor
Public Health Interventions Research Group, Kirby Institute Level 6, University of New South Wales, Wallace Wurth Building, Sydney, Australia
Interests: neglected tropical diseases; malaria and NTDs control and elimination in developing countries; intervention studies to inform health policy changes for more effective and sustainable disease control strategies; WASH and chemotherapy for NTD control; soil-transmitted helminths
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In the developed world, helminthic diseases, many of which are neglected tropical diseases (NTDs), no longer present the public health problem they once did. Helminthic infections, however, still inflict a heavy disease burden on millions in the tropics, where many of the world´s poorest and most vulnerable communities live. This Special Issue aims to turn a spotlight on current helminthic diseases (majorly neglected helminthic diseases) research by gathering research and opinions in a single Special Issue. Studies and commentaries on all themes related to helminthic diseases, including onchocerciasis, lymphatic filariasis, schistosomiasis, and soil-transmitted helminths, as well as food-borne trematode infections, are welcomed. Research and opinions on mansonellosis, loiasis, dirofilariasis, and other severely neglected helminthic diseases is especially encouraged. Manuscripts dealing with a wide range of themes, including parasite and vector biology, taxonomy, diagnostics, and epidemiology, will all be considered. Research related to emerging technologies and artificial intelligence, as applied to helminthic diseases, is encouraged, as are new perspectives and advances made using traditional methodologies.

Dr. James Lee Crainey
Prof. Dr. Susana Vaz Nery
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Tropical Medicine and Infectious Disease is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neglected helminthic diseases
  • helminth infections
  • parasite and vector biology
  • diagnostics
  • epidemiology
  • emerging technologies like artificial intelligence

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Published Papers (2 papers)

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30 pages, 5433 KB  
Systematic Review
Strongyloides stercoralis Infection in Humans in West Africa, 1975–2024: Systematic Review and Meta-Analysis
by Rufin K. Assaré, Mamadou Ouattara, Sören L. Becker, Fidèle K. Bassa, Nana R. Diakité, Jürg Utzinger and Eliézer K. N’Goran
Trop. Med. Infect. Dis. 2025, 10(11), 321; https://doi.org/10.3390/tropicalmed10110321 - 17 Nov 2025
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Abstract
Strongyloidiasis is an underappreciated helminth infection that belongs to a group of neglected tropical diseases. The aim of this systematic review and meta-analysis was to determine the pooled prevalence of Strongyloides stercoralis infection in humans in 16 West African countries. We searched African [...] Read more.
Strongyloidiasis is an underappreciated helminth infection that belongs to a group of neglected tropical diseases. The aim of this systematic review and meta-analysis was to determine the pooled prevalence of Strongyloides stercoralis infection in humans in 16 West African countries. We searched African Journals Online, Embase, Horizon, Google Scholar, ProQuest, PubMed, Scopus, and Web of Science to identify articles assessing S. stercoralis prevalence data. The search was restricted to articles published between 1 January 1975 and 31 December 2024 without language restriction. We followed the PRISMA guidelines. A total of 21,250 articles were identified, 336 of which met the inclusion criteria. The most frequently used diagnostic tools were Kato-Katz (35.1%) and formol-ether coprological methods (23.4%). Strongyloidiasis was reported in 15 of the 16 West African countries; Mali was the only country where it was absent. The S. stercoralis regional prevalence was 4.4%, ranging from 0.2% in Burkina Faso to 18.9% in The Gambia. S. stercoralis infection prevalence decreased from 14.0% (1975–1984) to 4.1% (2015–2024). S. stercoralis prevalence showed strong heterogeneity with the highest prevalence mainly observed in countries in the Gulf of Guinea. Most of the employed diagnostic techniques were inappropriate; the reported S. stercoralis prevalence is, thus, likely an underestimation of the true situation. Our observations call for more sensitive S. stercoralis diagnostic tools and strategies for strongyloidiasis control that are tailored to the different social-ecological settings of West Africa. Full article
(This article belongs to the Special Issue Research Advances and New Perspectives on Helminthic Diseases)
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7 pages, 792 KB  
Brief Report
Praziquantel Pretreatment Reduces Schistosoma japonicum Infection in Mice by Targeting Immature Worm Stages
by Xiang Gui, Rongxue Lv, Haoran Zhong, Hao Li, Ke Lu, Zhiqiang Fu, Yamei Jin and Jinming Liu
Trop. Med. Infect. Dis. 2025, 10(9), 262; https://doi.org/10.3390/tropicalmed10090262 - 12 Sep 2025
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Abstract
Schistosomiasis remains a significant public health concern, with Schistosoma japonicum infection endemic in certain regions of Asia. Praziquantel (PZQ), primarily known as an effective therapeutic agent, has recently shown potential as a prophylactic measure against delayed S. japonicum infections. This study investigated the [...] Read more.
Schistosomiasis remains a significant public health concern, with Schistosoma japonicum infection endemic in certain regions of Asia. Praziquantel (PZQ), primarily known as an effective therapeutic agent, has recently shown potential as a prophylactic measure against delayed S. japonicum infections. This study investigated the preventive efficacy of PZQ pretreatment at varying cercarial infection intensities and determined the parasite developmental stages targeted by the pretreatment in a mouse model. Results demonstrated that PZQ pretreatment significantly reduced both worm burdens and liver egg counts at low (10 and 20 cercariae) and high (100 cercariae) infection intensities, with reductions in worm burdens ranging from approximately 48% to 60% and liver egg counts by 47% to 73% compared to control groups (p < 0.05). Further analysis revealed that the mortality of parasites in PZQ-pretreated mice predominantly occurred during the juvenile schistosomula stages, particularly in worms younger than 15 days post-infection. These findings provide critical evidence supporting the application of PZQ pretreatment as a practical prophylactic measure to prevent S. japonicum infections, particularly in populations and animals frequently exposed to contaminated water in endemic areas. Full article
(This article belongs to the Special Issue Research Advances and New Perspectives on Helminthic Diseases)
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