Advances in Multiple Sclerosis, Third Edition
A special issue of Neurology International (ISSN 2035-8377).
Deadline for manuscript submissions: 30 June 2026
Special Issue Editor
Interests: multiple sclerosis; biomarkers; neurorehabilitation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In recent years, the management of multiple sclerosis (MS) and related disorders, including neuromyelitis optica spectrum disorder (NMOSD) and MOG-antibody-associated disease (MOGAD), has undergone a profound transformation, driven by advances in clinical research, neuroimaging, and biomarker discovery.
The updated 2024 McDonald diagnostic criteria now allow for earlier and more accurate diagnosis, integrating novel elements such as optic nerve involvement, CSF kappa free light chains (kFLCs), and advanced MRI markers, including the central vein sign and paramagnetic rim lesions. In particular, the possibility of diagnosing MS in patients with radiologically isolated syndrome (RIS) (when combined with biomarker evidence) has implications for treatment and, more generally, for preventative neurology.
At the same time, our understanding of disease progression is evolving. Traditional subtypes (RRMS, SPMS, PPMS) are increasingly viewed as points along a continuum of disease activity, rather than distinct entities. Recent AI-driven analyses suggest that MS should be described using dynamic features reflecting the biology of MS and its clinical expression, rather than fixed categories. This paradigm shift supports the use of a personalized, biology-based approach to treatment. Moreover, new biomarkers of progression are emerging as predictors of aggressive disease, enabling earlier identification of patients who may benefit from high-efficacy therapies. Integrating clinical assessment, biofluid biomarkers, and advanced MRI is now central to MS care.
We welcome reviews, original research, short communications, and case reports that provide new insights into the evolving landscape of MS and related disorders.
Dr. Marcello Moccia
Guest Editor
Manuscript Submission Information
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Keywords
- multiple sclerosis
- clinical
- treatment
- cognition
- biomarkers
- neuroimmunology
- neuroimaging
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Related Special Issues
- Advances in Multiple Sclerosis in Neurology International (6 articles)
- Advances in Multiple Sclerosis, Volume II in Neurology International (2 articles)
