Debris Clearance by Microglia in Health and Disease
A special issue of Neuroglia (ISSN 2571-6980).
Deadline for manuscript submissions: 31 January 2025 | Viewed by 339
Special Issue Editors
Interests: microglia; neurodegeneration; epigenetics; metabolism; cellular stress response pathways
2. Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain
Interests: astrocytes; microglia; neuroinflammation; phagocytosis; autophagy
Special Issue Information
Dear Colleagues,
Microglia are the brain’s primary phagocytes. As such, a core function of microglia in maintaining tissue homeostasis, regulating inflammation and promoting regeneration involves the phagocytic clearance of apoptotic cells, cellular debris, myelin and protein aggregates. This clearance function is amplified in development, brain injury, aging and neurodegenerative diseases, including Alzheimer’s, Parkinson’s, Huntington’s disease, amyotrophic lateral sclerosis, multiple sclerosis, frontotemporal dementia and Pick’s disease. Furthermore, it can protect the brain from debris accumulation. The clearance potential of microglia declines with aging, and an insufficient clearance of microglia is thought to contribute to the pathology of several neurodegenerative diseases, most notably Alzheimer’s disease. Microglial phagocytic clearance can also go awry during disease and aberrantly remove healthy neurons and synapses, exacerbating neurodegeneration. Therefore, elucidating the molecular mechanisms underlying microglial phagocytosis is critical in furthering our understanding of brain development, aging and diseases.
The purpose of this Special Issue is to receive original research articles and reviews that focus on recognition and regulatory mechanisms, as well as the functional outcomes of microglial phagocytic clearance and downstream epigenetic, transcriptional and metabolic events that result from microglial clearance activity.
Dr. Pinar Ayata
Dr. Maria-Angeles Arevalo
Guest Editors
Manuscript Submission Information
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Keywords
- microglia
- phagocytosis
- neurodegeneration
- neuroinflammation
- debris clearance
- regeneration
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