Mechanisms of Muscle Homeostasis in Health and Disease: From Specification of Muscle Progenitors to Muscle Fibre Maintenance
A special issue of Muscles (ISSN 2813-0413).
Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 3514
Skeletal muscles account for 30–40% of the total weight in humans and contribute to skeletal support, thermoregulation, and metabolism, beyond force generation for movement. Therefore, pathological conditions impinging on muscle development, maintenance and function severely impact quality of life.
Muscles experience continued physical stress, and thus require finely tuned mechanisms to preserve homeostatic equilibrium. Healthy muscle is capable of self-repair and locally regenerates due to resident stem cells and named satellite cells, which ensure both myofibre homeostasis, hypertrophy, repair and regeneration, highly sophisticated processes that partially recapitulate embryonic muscle development. Indeed, defective myogenic steps, such as altered proliferation, differentiation or cell fusion strongly impinge on the ability of embryonic myoblasts, or adult satellite cells, to form or regenerate muscle fibres.
The main purpose of this Special Issue, entitled ‘Mechanisms of Muscle Homeostasis in Health and Disease: From Specification of Muscle Progenitors to Muscle Fibre Maintenance’, is to gather new experimental insights or thought-provoking review articles that aim to shed light on intricate cellular and molecular regulation as the basis of muscle homeostasis and contribute to a better understanding of muscle development and regeneration in health and disease, possibly proposing potential therapeutic approaches for pathological conditions where muscle homeostasis is compromised.
Dr. Massimo Ganassi
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Muscles is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- satellite cells
- muscle regeneration
- muscle development
- neuromuscular disorders
- myoblast differentiation and fusion
- muscle homeostasis
- muscle hypertrophy and hyperplasia