Developmental Mechanisms in Tumorigenesis

A special issue of Journal of Developmental Biology (ISSN 2221-3759).

Deadline for manuscript submissions: closed (30 June 2016) | Viewed by 5798

Special Issue Editor


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Guest Editor
Department of Health Technology and Informatics, Faculty of Health and Social Sciences, Hong Kong Polytechnic University, Hong Kong

Special Issue Information

Dear Colleagues,

Genomic profiling technologies have experienced major improvements in recent years. Such advances have facilitated the discovery of potential tumor markers with improved sensitivities and specificities for the diagnosis, prognosis and treatment monitoring of cancer patients. From the discovery of novel biomarkers, there is still a large gap until they are translated into clinical applications. In the era of big data and precision medicine, novel gene interactions in various signaling pathways can be revealed with clinical significance. In line with this, the process of developmental mechanisms in tumorigenesis is generating new knowledge which will improve future cancer patients’ treatment strategies.

Prof. Benjamin Yat-Ming Yung
Guest Editor

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Keywords

  • genomic profiling
  • big data
  • precision medicine
  • gene interactions
  • treatment strategies

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Published Papers (1 paper)

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Article
Nutrient-Deprived Retinal Progenitors Proliferate in Response to Hypoxia: Interaction of the HIF-1 and mTOR Pathway
by Helena Khaliullina, Nicola K. Love and William A. Harris
J. Dev. Biol. 2016, 4(2), 17; https://doi.org/10.3390/jdb4020017 - 19 May 2016
Cited by 8 | Viewed by 5465
Abstract
At a cellular level, nutrients are sensed by the mechanistic Target of Rapamycin (mTOR). The response of cells to hypoxia is regulated via action of the oxygen sensor Hypoxia-Inducible Factor 1 (HIF-1). During development, injury and disease, tissues might face conditions of both [...] Read more.
At a cellular level, nutrients are sensed by the mechanistic Target of Rapamycin (mTOR). The response of cells to hypoxia is regulated via action of the oxygen sensor Hypoxia-Inducible Factor 1 (HIF-1). During development, injury and disease, tissues might face conditions of both low nutrient supply and low oxygen, yet it is not clear how cells adapt to both nutrient restriction and hypoxia, or how mTOR and HIF-1 interact in such conditions. Here we explore this question in vivo with respect to cell proliferation using the ciliary marginal zone (CMZ) of Xenopus. We found that both nutrient-deprivation and hypoxia cause retinal progenitors to decrease their proliferation, yet when nutrient-deprived progenitors are exposed to hypoxia there is an unexpected rise in cell proliferation. This increase, mediated by HIF-1 signalling, is dependent on glutaminolysis and reactivation of the mTOR pathway. We discuss how these findings in non-transformed tissue may also shed light on the ability of cancer cells in poorly vascularised solid tumours to proliferate. Full article
(This article belongs to the Special Issue Developmental Mechanisms in Tumorigenesis)
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