Advancements in the Management of Aortic Stenosis: The Importance of Early Detection and Timely Treatment
A Special Issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425) belonging to the section "Cardiovascular Clinical Research".
Deadline for manuscript submissions: 25 November 2026 | Viewed by 633
Editors
Interests: cardiology; precision medicine; residual risk; acute coronary syndrome; percutaneous coronary intervention; PCI
Special Issues, Collections and Topics in MDPI journals
2. Division of Cardiology, Ospedale Umberto I, ASP 4 di Enna, 94100 Enna, Italy
Interests: cardiology; interventional cardiology; left atrial appendage closure (LAAC); coronary artery disease; transcatheter aortic valve replacement (TAVR)
Special Issue Information
Dear Colleagues,
Severe aortic stenosis represents one of the most common and clinically relevant valvular heart diseases in the ageing population. For many years, access to transcatheter aortic valve replacement (TAVR) was limited by procedural risk, anatomical feasibility, and resource availability. However, the progressive increase in life expectancy has led to a growing prevalence of degenerative aortic valve disease, while the expansion of TAVR indications to younger patients and those at lower surgical risk has markedly increased referral volumes.
This evolution has been driven by major technological advancements. Newer-generation transcatheter valves have significantly improved procedural safety, reduced complication rates, and provided more favourable long-term outcomes. At the same time, advances in multimodality imaging and screening strategies are improving our ability to identify patients at higher risk of disease progression and to detect early myocardial damage before the onset of symptoms.
These developments highlight the importance of timely intervention and accurate patient selection. In particular, some clinical scenarios remain especially challenging in terms of optimal treatment timing and technical complexity, such as patients with severe asymptomatic aortic stenosis and those with bicuspid aortic valve anatomy.
This Special Issue aims to provide an updated overview of current advances in the diagnosis, risk stratification, and management of aortic stenosis, with a focus on early detection strategies, evolving indications for intervention, and the technical and clinical challenges associated with complex patient subsets. We welcome original research articles, reviews, and expert perspectives addressing advances in imaging, patient selection, transcatheter therapies, and long-term outcomes in the management of aortic stenosis.
Prof. Dr. Antonio Micari
Guest Editor
Dr. Giulia Laterra
Guest Editor Assistant
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Cardiovascular Development and Disease is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- aortic stenosis
- transcatheter aortic valve replacement
- early intervention
- risk stratification
- bicuspid aortic valve
- cardiac imaging
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