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JCDD
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In Vitro Models for Cardiac Development, Regeneration, and Disease: Advances...
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In Vitro Models for Cardiac Development, Regeneration, and Disease: Advances and Challenges

A special issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425). This special issue belongs to the section "Cardiac Development and Regeneration".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 209

Special Issue Editors

Prof. Dr. Richard T. Lee

E-Mail Website
Guest Editor
1. Department of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, 7 Divinity Ave, Cambridge, MA 02138, USA
2. Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
Interests: cardiac disease; cardiac regeneration; metabolism; aging
Special Issues, Collections and Topics in MDPI journals
Dr. Nivedhitha Velayutham

E-Mail Website
Guest Editor Assistant
Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
Interests: cardiac regeneration; cardiac development; stem cell-derived models

Special Issue Information

Dear Colleagues,

This Special Issue of JCDD will highlight the critical role of in vitro models in advancing research on cardiac development, regeneration, and disease. It will focus on the latest advancements and challenges in the development and utilization of in vitro models of the heart, including tissue-derived cell culture systems, stem cell-derived cardiac models, co-culture systems, spheroid and organoid models, organ-on-chip platforms, 3D bioprinting, matrix/hydrogel systems, bioreactor scale-up cultures, and other emerging technologies. Manuscripts that utilize in vitro cardiac models to provide novel perspectives into the molecular and cellular mechanisms of cardiac development, regeneration, and disease are also welcome. We hope this Special Issue offers valuable insights into the current and future landscape of in vitro technologies to understand cardiac biology and develop effective therapeutics for heart disease.

We welcome submissions of original research and review articles that spotlight current advances and challenges, as well as anticipated future developments, in the application of in vitro models to study cardiac development, regeneration, and disease.

Prof. Dr. Richard T. Lee
Guest Editor

Dr. Nivedhitha Velayutham
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Cardiovascular Development and Disease is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • in vitro models
  • stem cell-derived cardiac cells
  • organ-on-chip platforms
  • 2D and 3D culture systems
  • co-culture models
  • cardiac regeneration
  • cellular therapies
  • heart disease modeling

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Published Papers (1 paper)

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Research

14 pages, 4004 KiB  
Article
Viability and Longevity of Human Miniaturized Living Myocardial Slices
by Ziyu Zhou, Yvar P. van Steenis, Surya Henry, Elisa C. H. van Doorn, Jorik H. Amesz, Pieter C. van de Woestijne, Natasja M. S. de Groot, Olivier C. Manintveld, Beatrijs Bartelds and Yannick J. H. J. Taverne
J. Cardiovasc. Dev. Dis. 2025, 12(7), 269; https://doi.org/10.3390/jcdd12070269 (registering DOI) - 15 Jul 2025
Abstract
Living myocardial slices (LMSs) have shown great promise in cardiac research, allowing multicellular and complex interplay analyses with disease and patient specificity, yet their wider clinical use is limited by the large tissue sizes usually required. We therefore produced mini-LMSs (<10 mm2 [...] Read more.
Living myocardial slices (LMSs) have shown great promise in cardiac research, allowing multicellular and complex interplay analyses with disease and patient specificity, yet their wider clinical use is limited by the large tissue sizes usually required. We therefore produced mini-LMSs (<10 mm2) from routine human cardiac surgery specimens and compared them with medium (10–30 mm2) and large (>30 mm2) slices. Size effects on biomechanical properties were examined with mathematical modeling, and viability, contraction profiles, and histological integrity were followed for 14 days. In total, 34 mini-, 25 medium, and 30 large LMS were maintained viable, the smallest measuring only 2 mm2. Peak twitch force proved to be size-independent, whereas time-to-peak shortened as slice area decreased. Downsized LMSs displayed excellent contractile behavior for five to six days, after which a gradual functional decline and micro-architectural changes emerged. These findings confirm, for the first time, that mini-LMSs are feasible and viable, enabling short-term, patient-specific functional studies and pharmacological testing when tissue is scarce. Full article
(This article belongs to the Special Issue In Vitro Models for Cardiac Development, Regeneration, and Disease: Advances and Challenges)
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