In Vitro Models for Cardiac Development, Regeneration, and Disease: Advances and Challenges

A special issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425). This special issue belongs to the section "Cardiac Development and Regeneration".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 139

Special Issue Editors


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Guest Editor
1. Department of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, 7 Divinity Ave, Cambridge, MA 02138, USA
2. Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
Interests: cardiac disease; cardiac regeneration; metabolism; aging
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Guest Editor Assistant
Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
Interests: cardiac regeneration; cardiac development; stem cell-derived models

Special Issue Information

Dear Colleagues,

This Special Issue of JCDD will highlight the critical role of in vitro models in advancing research on cardiac development, regeneration, and disease. It will focus on the latest advancements and challenges in the development and utilization of in vitro models of the heart, including tissue-derived cell culture systems, stem cell-derived cardiac models, co-culture systems, spheroid and organoid models, organ-on-chip platforms, 3D bioprinting, matrix/hydrogel systems, bioreactor scale-up cultures, and other emerging technologies. Manuscripts that utilize in vitro cardiac models to provide novel perspectives into the molecular and cellular mechanisms of cardiac development, regeneration, and disease are also welcome. We hope this Special Issue offers valuable insights into the current and future landscape of in vitro technologies to understand cardiac biology and develop effective therapeutics for heart disease.

We welcome submissions of original research and review articles that spotlight current advances and challenges, as well as anticipated future developments, in the application of in vitro models to study cardiac development, regeneration, and disease.

Prof. Dr. Richard T. Lee
Guest Editor

Dr. Nivedhitha Velayutham
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Cardiovascular Development and Disease is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • in vitro models
  • stem cell-derived cardiac cells
  • organ-on-chip platforms
  • 2D and 3D culture systems
  • co-culture models
  • cardiac regeneration
  • cellular therapies
  • heart disease modeling

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Published Papers

This special issue is now open for submission.
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