Arrhythmic Risk Stratification, 2nd Edition

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Guest Editor
De Gasperis Cardio Center and Transplant Center, Niguarda Hospital, 20126 Milan, Italy
Interests: arrhythmic risk stratification; sudden death; genetics; arrhythmogenic dysplasia; hypertrophic heart disease; inflammatory cardiomyopathy; dilated cardiomyopathy; ischaemic cardiomyopathy; channelopathies; cardiac magnetic resonance; late gadolinium enhancement; multiparametric evaluation; ventricular arrhythmias; heart failure; electrophysiological study; ventricular arrhythmia ablation
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
De Gasperis Cardio Center and Transplant Center, Niguarda Hospital, 20126 Milan, Italy
Interests: ventricular arrhythmias; sudden death; genetics; electrophysiology study; ablation of ventricular arrhythmias
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Sudden cardiac death remains a major concern, accounting for 50% of all cardiovascular-related mortality. Notably, in half of the cases it represents the first manifestation of disease, with incidence increasing with age.

The 2022 ESC guidelines highlight the crucial role of comprehensive diagnostic evaluation and arrhythmic risk stratification across different clinical scenarios. They also provide important updates on the value of cardiac magnetic resonance imaging and genetic testing, while underscoring the need for a multidisciplinary approach involving clinical cardiologists, electrophysiologists, and cardiac imaging specialists.

Despite these advances, a considerable number of patients still fall into a grey zone, where making the most appropriate management decision remains challenging.

The aim of this Special Issue is to gather experiences and perspectives on “arrhythmic risk stratification” in patients with various forms of cardiomyopathy and channelopathy. We welcome both review articles and original research contributions, with the shared goal of advancing discussion on this complex topic and ultimately improving patient care.

Dr. Marisa Varrenti
Dr. Patrizio Mazzone
Guest Editors

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Keywords

  • cardiomyopathies
  • channelopathies
  • arrhythmic risk
  • ventricular arrhythmias
  • sudden death
  • genetics
  • cardiac MRI
  • ablation of ventricular arrhythmias

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Published Papers (1 paper)

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Review

14 pages, 1471 KB  
Review
Left Ventricular Ring-like Pattern: The Arrhythmic Tale of a Scarred Heart
by Vanda Parisi, Claudio Bergami, Ferdinando Pasquale, Maria Alessandra Schiavo, Irene Ruotolo, Naomi Fanciullo, Nicolò Sini, Matteo Ziacchi, Mauro Biffi, Raffaello Ditaranto, Maddalena Graziosi and Elena Biagini
J. Cardiovasc. Dev. Dis. 2025, 12(7), 275; https://doi.org/10.3390/jcdd12070275 - 17 Jul 2025
Viewed by 913
Abstract
Cardiac magnetic resonance (CMR) imaging provides significant advantages in the non-invasive diagnosis of cardiac diseases. An emerging phenotype is increasingly being described in CMR reports, the LGE “ring-like” pattern, which resembles a circumferential/semi-circumferential LV scar. Different conditions exhibit this fibrosis distribution, the majority [...] Read more.
Cardiac magnetic resonance (CMR) imaging provides significant advantages in the non-invasive diagnosis of cardiac diseases. An emerging phenotype is increasingly being described in CMR reports, the LGE “ring-like” pattern, which resembles a circumferential/semi-circumferential LV scar. Different conditions exhibit this fibrosis distribution, the majority of them being genetically determined and mostly involving cardiomyopathy-causative genes (desmosomal but also other non-desmosomal related genes). Furthermore, inflammatory diseases, such as myocarditis or sarcoidosis, could be responsible for LV fibrosis, potentially exhibiting an RL distribution. Given the heterogeneity of such conditions, effective patient management requires a stepwise and multiparametric diagnostic work-up that integrates clinical, instrumental, and genetic data to identify the specific aetiology and guide personalised treatments. Full article
(This article belongs to the Special Issue Arrhythmic Risk Stratification, 2nd Edition)
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