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2.6
Journals
Hygiene
Special Issues
Dental Biofilm Control and Oral Health
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Dental Biofilm Control and Oral Health

A special issue of Hygiene (ISSN 2673-947X).

Deadline for manuscript submissions: closed (15 September 2025) | Viewed by 1052

Special Issue Editor

Dr. Sotirios Kalfas

E-Mail Website
Guest Editor
Department of Preventive Dentistry, Periodontology, and Implant Biology, School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Interests: oral microbiology and immunology; preventive dentistry; periodontology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue may include original articles, systematic reviews, and meta-analyses that are focused on the following topics:

  • Mechanical and chemical methods to inhibit the formation and maturation of dental biofilms in the supragingival and subgingival areas.
  • New cleaning devices and chemical compounds that can be used and their effectiveness in inhibiting biofilm formation and promoting dental and periodontal health.
  • Mechanisms of action in relation to the etiopathogenesis of dental caries and periodontal and peri-implant diseases.
  • Therapeutic applications of biofilm-inhibiting measures and their effectiveness against dental and oral diseases.

Dr. Sotirios Kalfas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Hygiene is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dental biofilms
  • oral microbiology
  • cleaning devices
  • dental health
  • biofilm-inhibiting measures

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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18 pages, 7985 KB  
Systematic Review
Efficacy and Safety of Natural Versus Conventional Toothpastes and Mouthwashes in Gingivitis Management: A Systematic Review
by Angelo Michele Inchingolo, Grazia Marinelli, Valeria Colonna, Benito Francesco Pio Pennacchio, Roberto Vito Giorgio, Francesco Inchingolo, Daniela Di Venere, Andrea Palermo, Giuseppe Minervini, Alessio Danilo Inchingolo and Gianna Dipalma
Hygiene 2025, 5(3), 38; https://doi.org/10.3390/hygiene5030038 - 4 Sep 2025
Viewed by 654
Abstract
Gingivitis is a common and reversible inflammatory condition caused by dental plaque accumulation, which, if left untreated, can progress to periodontitis. Conventional oral care products like chlorhexidine (CHX) and fluoride are effective in plaque control but are often associated with adverse effects such [...] Read more.
Gingivitis is a common and reversible inflammatory condition caused by dental plaque accumulation, which, if left untreated, can progress to periodontitis. Conventional oral care products like chlorhexidine (CHX) and fluoride are effective in plaque control but are often associated with adverse effects such as dental staining and mucosal irritation. This systematic review aimed to compare the efficacy and safety of natural versus conventional toothpastes and mouthwashes in managing plaque-induced gingivitis. The review followed PRISMA guidelines and was registered in PROSPERO (No. 1008296). A systematic search was conducted across PubMed, Web of Science, and Scopus for English-language clinical studies published between 2015 and 2025. Eligible studies included randomized controlled trials and clinical trials on human subjects with plaque-induced gingivitis. Exclusion criteria were studies on animals, in vitro experiments, review articles, and studies lacking control groups. Data extracted included intervention type, sample characteristics, clinical indices (PI, GI, SBI), inflammatory biomarkers, adverse events, and patient adherence. A narrative synthesis was conducted due to study heterogeneity. Fifteen studies were included. Natural products such as neem, green tea, aloe vera, and propolis demonstrated comparable effectiveness to CHX and fluoride in reducing gingival inflammation and plaque indices, with a lower incidence of side effects. In particular, natural formulations showed superior tolerability and better patient compliance, especially in long-term use. However, variability in concentration and the formulation of natural products limits their clinical standardization. In conclusion, natural oral care products appear to be effective and better-tolerated alternatives to conventional agents in managing gingivitis. Nonetheless, further long-term, standardized clinical trials are needed to confirm their efficacy and define optimal formulations. Full article
(This article belongs to the Special Issue Dental Biofilm Control and Oral Health)
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