New Factors in Cell-Cell Communication between Monocyte/Macrophage and Cardiac Resident Cells during Cardiac Injury and Repair
A special issue of Hearts (ISSN 2673-3846).
Deadline for manuscript submissions: closed (31 July 2022) | Viewed by 540
Special Issue Editors
Interests: inflammation; myocardial infarction; myocarditis; monocytes/macrophages; immunomodulation; Wnt signaling
2. DZHK (German Centre for Cardiovascular Research), Partner site Heidelberg/Mannheim, Heidelberg, Germany
Interests: immunocardiology; innate immunity; leukocyte kinetics; leukocyte activation
Special Issue Information
Dear Colleagues,
The innate immune response is the first line of defense that protects us from invading pathogens and infections. However, it is now well established that cells of the innate immunity also participate in sterile inflammation and tissue repair. Cells of the myeloid cell lineage, especially monocytes and macrophages, have been identified as crucial players in the healing myocardium.
In response to cardiac injury, cardiac resident macrophages proliferate, and high numbers of monocytes infiltrate the heart, where they interact with various cell types including cardiomyocytes, fibroblasts, and endothelial cells. Recent technical advances have revealed a tremendous plasticity and heterogeneity within the myeloid cell compartment in the injured heart. This is also reflected by the variety of tasks monocytes and macrophages fulfill during cardiac repair, ranging from the removal of dead cells and tissue debris, promoting angiogenesis, to coordinating extracellular matrix deposition. However, little is known about the factors released in the cardiac niche that guide monocyte/macrophage function and may coordinate monocyte/macrophage plasticity and heterogeneity.
This Special Issue is dedicated to research that advances our understanding of mechanisms and factors that play a role in cell-cell communication between cardiac resident cells and monocyte macrophages and determine their cellular fate and function during cardiac repair.
Dr. Sören Meyer
Prof. Florian Leuschner
Guest Editors
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Keywords
- Monocytes/Macrophages
- inflammation
- monocyte/macrophage differentiation
- monocyte/macrophage heterogeneity
- cell-cell communication
- myocardial injury
- cardiac remodeling
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