Insights into the Genomic and Genetic Basis of Cardiovascular Disease
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".
Deadline for manuscript submissions: 10 December 2025 | Viewed by 671
Special Issue Editors
Interests: acute coronary syndromes; cardio-oncology; pericardial diseases; atrial fibrillation
Interests: pharmacogenetics/genomics; precision medicine and gender medicine in inherited thrombophilia and cardiovascular disease; coagulation; iron homeostasis and folate pathways; genetics of wound healing; childhood haematological malignancies
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Special Issue Information
Dear Colleagues,
In the real world, clinicians who deal with the various branches of cardiology (cardiomyopathy, inflammatory diseases, arrhythmias, coronary syndromes, etc.) often need a genetic consultation to better characterize individual patients and practice precision medicine. Sharing cases with geneticists will be increasingly frequent and is essential for good clinical practice.
Background: Over the past two decades, genetic analysis has allowed us to characterize patients with cardiovascular disease in a more thorough and precise way. The progress in understanding the genetic basis of cardiovascular disease has allowed clinical cardiologists to treat patients with greater precision, improving their survival. Progress in the field of cardiomyopathies and channelopathies has been remarkable, and, in the near future, we will be able to better characterize some currently "idiopathic" pathologies (inflammatory heart disease, arrhythmias, spontaneous coronary dissection, etc.).
Aim and scope: The aim of this Special Issue is to present the most recent advances in genetics in some cardiovascular diseases in order to update the knowledge of clinicians and to improve daily clinical practice.
History: In recent decades, genetic analysis has allowed us to better characterize patients with cardiomyopathies (e.g., arrhythmogenic dysplasia, hypertrophic cardiomyopathy, dilated cardiomyopathy, transthyretin amyloidosis) and channelopathies (e.g., long QT and Brugada). In the coming years, we will be able to give a name to some seemingly idiopathic pathologies, which instead have a genetic basis, such as idiopathic ventricular fibrillation, atrial fibrillation without signs of structural heart disease, recurrent pericarditis and perimyocarditis, spontaneous coronary dissection, or anti-cancer drug cardiotoxicity.
Cutting-edge research: Research has achieved many advances in the definition of cardiomyopathies and channelopathies for the prevention of heart failure progression and sudden death. At present, however, we need to enrich our knowledge regarding apparently idiopathic malignant ventricular arrhythmias, acute coronary syndromes from spontaneous dissection, myocarditis, and recurrent pericarditis. Finally, in the field of cardio-oncology, we do not know why some patients develop some forms of early or late cardiotoxicity; could genetic analysis direct the oncologist to choose alternative therapies or the cardiologist to adopt cardioprotective therapies?
What kind of papers we are soliciting: We are looking for up-to-date reviews with the latest findings in cardiovascular genetics, but we also accept original articles and other types.
Dr. Marzia de Biasio
Prof. Dr. Donato Gemmati
Guest Editors
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Keywords
- recurrent idiopathic pericarditis and perimyocarditis
- spontaneous coronary dissection
- sudden idiopathic cardiac death
- idiopathic atrial fibrillation
- cardio-oncology and cardio toxicity of anti anti-cancer drugs
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