Genetics of Familial Prostate Cancer
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (10 February 2024) | Viewed by 322
Special Issue Editors
Interests: prostate cancer; genetics; epigenetics; functional genetics; transcription factor; risk factor; targeted therapy; genetic counseling
Special Issue Information
Dear Colleagues,
Prostate cancer (PCa) is the second most frequently diagnosed cancer and the fifth leading cause of cancer death in men. There are millions of new prostate cancer cases and millions of associated deaths every year worldwide. Inherited genetic mutations/alterations are the most important risk factor for PCa and might be associated with tumor metastasis and outcome. Genetic research has greatly contributed to PCa predisposition determination and screening strategies, the identification of hereditary cancer, drug development and precision medicine. A large number of PCa-associated genetic variants have been identified in epidemiological studies; however, the molecular mechanisms of these genetic mutations and how these findings support therapeutic development remain unclear. Furthermore, genome-wide association study (GWAS) has identified hundreds of loci associated with the risk of PCa development, conferring high familial risk for PCa. To date, the accuracy and necessity of germline testing for prostate cancer in men remain controversial. Germline genetic testing is now highly recommended for advanced prostate cancer patients, particularly given its significance for targeted treatment. In addition, genetic testing is beneficial at various stages of PCa and for men at high hereditary risk for prostate cancer. Thus, more attention should be given to genetics studies on familial PCa, clinical genetic testing and its impact on cancer screening and counseling and treatment for at-risk family members.
For this Special Issue, we are interested in recent advances in the field and discussion on the genetics of familial prostate cancer. Research papers and reviews should focus on, but are not limited to, the following: the study of PCa epidemiology, mate analyses of genetics of PCa, hereditary PCa, germline mutation/alterations, single-nucleotide polymorphisms, genetic screening for hereditary PCa, surveillance for PCa, functional genome research to enhance the biological understanding of PCa, biology network research to advance the current PCa disease pathway/network, genetic testing for precision treatment and genetic clinical trials.
Dr. Jihan Xia
Dr. Shicheng Guo
Guest Editors
Manuscript Submission Information
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Keywords
- prostate cancer
- genetics and epigenetics
- hereditary cancers
- germline mutation/alterations
- genetic testing
- targeted therapy
- genetic counseling
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