Molecular and Genetic Mechanism of Tumorigenesis
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (1 April 2022) | Viewed by 4114
Special Issue Editors
Interests: cell proliferation; migration; apoptosis; tumorigenesis; tumor invasion
Interests: DNA damage response; cell cycle; apoptosis
Interests: The Hippo pathway; signal transduction; organ size control; tumorigenesis
Interests: tumorigenesis; metastasis; miRNA; cell death; cancer therapy
Special Issue Information
Dear Colleagues,
Cancer is one of the most fatal diseases that threaten human health, whereas more than 90% mortality of cancer patients is caused by tumor metastasis, rather than the growth of primary tumors. Understanding the molecular mechanism of tumor growth and progression is of great significance for cancer therapy.
Tumorigenesis is the gain of malignant properties in normal cells. Somatic copy-number changes, variants and mutations in genomic regions, and epigenetic modifications, etc., have been associated with tumorigenesis. Tumor metastasis is a process of cancer cells disseminating from a primary lesion via lymphatic and/or blood circulations to distal organs, which involves a variety of cellular mechanisms. Over the past decades, great progress has been made in exploring the mechanisms of tumor progression, in which numerous oncogenes, tumor suppressor genes, and multiple signaling pathways (e.g., Raf-MAPK, JNK, WNT, Hippo, Notch, JAK-STAT, and PI3K/AKT) have been implicated in tumor growth and metastasis. However, many questions still remain unanswered about the precise mechanism underlying tumorigenesis and metastasis.
In this Special Issue, we welcome original research, reviews, perspective and opinion articles providing noval insights to molecular mechanisms for tumorigenesis and metastasis, as well as the latest progress related to new biomarkers, therapeutic targets and development of new treatment strategies that will contribute to improved therapeutic efficacy and prognosis for cancer patients.
Prof. Dr. Lei Xue
Prof. Dr. Xiaolin Bi
Prof. Dr. Shian Wu
Prof. Dr. Xiaoping Zhang
Guest Editors
Manuscript Submission Information
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Keywords
- cell death
- cell proliferation and migration
- oncogene and tumor suppressor genes
- tumorigenesis, invasion and metastasis
- tumor diagnosis and therapy
- tumor-related signalling pathways
