DNA Damage, Genome Stability and Human Disease
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (20 January 2023) | Viewed by 336
Special Issue Editors
Interests: DNA repair; DNA damage; prostate cancer; breast cancer
Interests: DNA damage; DNA replication; DNA repair; signal transduction; genome maintenance; carcinogenesis
Special Issue Information
Dear Colleagues,
Prostate cancer remains a significant cause of death worldwide, with approximately 350,000 men succumbing to the disease each year. Recent advances in the identification of risk factors and improved therapeutic approaches have increased the 5-year survival rate in the United States, but prostate cancer continues to rank as the second leading cause of death among American men. Many of the molecular mechanisms responsible for prostate cancer development and progression are gradually coming to light. Recently published meta-analyses indicate that germline and acquired mutations in DNA repair genes appear frequently in prostate cancer. Although the mechanistic and clinical significance of these alterations is little explored, defects in DNA repair and DNA damage response (DDR) genes may provide promising therapeutic opportunities for patients with prostate cancer. Clearly, more investigations are needed concerning the impact of DNA repair on prostate cancer etiology and therapy. Therefore, we invite investigators to contribute review and research articles on DNA repair, the DNA damage response, genome instability, and translational research in prostate cancer for a Special Edition of Genes entitled “DNA Damage, Genome Stability and Human Disease.” We markedly look forward to your contributions.
Dr. Tomida Junya
Prof. Dr. Cyrus Vaziri
Guest Editors
Manuscript Submission Information
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Keywords
- DNA damage
- genome stability
- DNA repair
- DNA replication
- cancer
- prostate cancer
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