The Ever-Expanding CRISPR/Cas Toolbox and Its Applications
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (15 July 2021) | Viewed by 461
Special Issue Editors
Interests: genome editing; CRISPR/Cas systems; DNA double-strand break repair and cellular responses
Interests: epigenetics; chromatin; Polycomb-group proteins; CRISPR
Special Issue Information
Dear Colleagues,
Due to their extreme simplicity, the applications of CRISPR-Cas systems have exploded in recent years, ranging from targeted genome sequence modification and modulation of gene transcription to genetic screens and diagnostics. Following on the Nobel Prize-winning characterization of targeted DNA cleavage by SpCas9, a great wealth of additions and improvements to the CRISPR-Cas toolbox have thus made it possible to develop a whole range of novel methods to investigate biological mechanisms and engineer new biotechnological applications.
In this Special Issue, we welcome reviews, new methods, and original articles covering the different possibilities offered by CRISPR-Cas systems and their implementation for investigating the genome in both basic and applied research, including recent developments of the best established applications, such as second-generation tools of gene editing, to emerging prospects for gene therapy in human disease and development of gene drives.
Dr. Jean-Paul Concordet
Dr. Michel Wassef
Dr. Emiliano Ricci
Guest Editors
Manuscript Submission Information
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Keywords
- gene editing
- CRISPR-Cas9
- epigenetics
- precision gene editing
- transcriptional control
- genome-wide screens
- gene drive
- gene therapy.
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