Genetics and Epigenetics in Neurodegenerative Diseases

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".

Deadline for manuscript submissions: closed (15 September 2024) | Viewed by 1601

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Instituto Mexicano del Seguro Social, Avenida Cuauhtémoc No. 330, Col. Doctores, Delegación Cuauhtémoc, México D.F. C.P. 06725, Mexico
Interests: genetics; geriatrics; dementia; cognitive decline; pharmacoepidemiology; pharmacogenetics; geriatrics
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Special Issue Information

Dear Colleagues,

Research has shown that neurodegenerative diseases are largely influenced by genetic and epigenetic factors. Certain diseases such as Alzheimer’s disease, dementia, amyotrophic lateral sclerosis, Parkinson’s disease can appear randomly or be inherited. Finding predispositions, familial patterns, and particular gene changes associated with vulnerability all depend on genetic studies. Knowing these genetic variables helps to quantify risk and sheds light on the underlying processes that lead to the development and progression of disease.

In summary, the aim of this special issue entitled “Genetics and Epigenetics in Neurodegenerative Diseases” is to highlight the significance of genetic and genomic studies in neurodegenerative diseases and to show the current state and future directions for early detection and treatment, as well as to get a deeper comprehension of the complex necessities driving neurodegenerative diseases. Colleagues are encouraged to submit manuscripts with original articles or reviews in this topic.

Prof. Dr. Teresa Juárez-Cedillo
Guest Editor

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Keywords

  • neurodegenerative disease
  • genetics
  • epigenetics
  • Alzheimer’s disease
  • dementia
  • Parkinson’s disease

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Published Papers (1 paper)

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Research

11 pages, 1650 KiB  
Article
Intergenic Interactions of ESR1, GSTO1 and AGER and Risk of Dementia in Community-Dwelling Elderly (SADEM Study)
by Teresa Juárez-Cedillo, Nancy Martínez-Rodríguez, Enrique Juárez-Cedillo, Alfredo Ramirez and Alan Suerna-Hernández
Genes 2024, 15(11), 1395; https://doi.org/10.3390/genes15111395 - 29 Oct 2024
Viewed by 980
Abstract
Background: Dementia causes the loss of functional independence, resulting in a decrease in the quality of life of those who suffer from it. Aims: This study aimed to investigate the interactions influencing susceptibility to the development of dementia through multifactor dimensionality reduction (MDR). [...] Read more.
Background: Dementia causes the loss of functional independence, resulting in a decrease in the quality of life of those who suffer from it. Aims: This study aimed to investigate the interactions influencing susceptibility to the development of dementia through multifactor dimensionality reduction (MDR). Methods: the study population was made up of 221 cases and 534 controls. We performed an MDR analysis as well as a bioinformatic analysis to identify interactions between the genes GSTO1_rs4925, AGER_rs2070600, and ESR1_rs3844508 associated with susceptibility to dementia. Results: We observed associations between the polymorphism of GSTO1 and risk of dementia for the site rs4925 with the recessive model (OR = 1.720, 95% CI = 1.166–2.537 p = 0.006). Similarly, the site AGER rs2070600 showed risk of dementia with an additive model of inheritance (OR = 7.278, 95% CI = 3.140–16.868; p < 0.001). Furthermore, we identified the best risk model with a high precision of 79.6% that, when combined with three environmental risk factors, did not give an OR = 26.662 95%CI (16.164–43.979) with p < 0.001. Conclusions: The MDR and bioinformatics results provide new information on the molecular pathogenesis of dementia, allowing identification of possible diagnostic markers and new therapeutic targets. Full article
(This article belongs to the Special Issue Genetics and Epigenetics in Neurodegenerative Diseases)
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