Opportunities and Prospects of Cancer Gene Therapy
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".
Deadline for manuscript submissions: 25 October 2025 | Viewed by 12
Special Issue Editor
Special Issue Information
Dear Colleagues,
Gene therapy has emerged as a promising and innovative approach in cancer treatment, offering targeted interventions by introducing therapeutic genes into cancer cells or tissues to induce cell death or inhibit tumor progression. Various strategies are being explored, including activating tumor suppressor genes, inhibiting oncogenes, suicide gene therapy, antiangiogenic approaches, and immunogenic therapy. These methods employ a wide range of therapeutic genes delivered through both viral and non-viral vectors, with each having unique advantages and challenges.
This Special Issue will bring together both original studies and reviews covering novel aspects of gene therapy for cancer. We specifically invite articles focusing on different strategies in cancer gene therapy in the following areas:
- Understanding biological and genetic processes involved in gene-based cancer therapies, e.g., gene regulation, signaling pathways, tumor microenvironment interactions, and mechanisms of resistance;
- Development and improvement of delivery platforms—both viral (e.g., adenovirus, lentivirus, AAV) and non-viral (e.g., nanoparticles, liposomes, exosomes);
- Combination with other treatment modalities such as chemotherapy, radiotherapy, immunotherapy, and targeted therapies;
- Translational applications in preclinical models, early-phase clinical trials, regulatory considerations, and case studies.
Dr. Ruoxi Zhang
Guest Editor
Manuscript Submission Information
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Keywords
- cancer gene therapy
- tumor suppressor gene activation
- oncogene inhibition
- suicide gene therapy
- antiangiogenic gene therapy
- immunogenic therapy
- viral and non-viral vectors
- targeted gene delivery
- translational cancer research
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