Genetics of Intracerebral Hemorrhage

Dear Colleagues,

Intracranial hemorrhage (ICH) represents a significant medical challenge, often leading to severe morbidity and mortality. Understanding the genetic underpinnings of ICH is crucial for elucidating its etiology, risk factors, and potential therapeutic targets. Recent advances in genomic technologies have opened new avenues for exploring the intricate relationships between genetic predisposition and the mechanisms underlying ICH. This Special Issue aims to gather insights from diverse research areas, including molecular genetics, genomics, clinical neurology, and neuroradiology, to foster a comprehensive understanding of the genetic factors contributing to intracranial hemorrhage.

The primary aim of this Special Issue is to highlight the latest discoveries in the genetics of intracranial hemorrhage and to explore how these findings can enhance our understanding of risk stratification, prevention, and treatment. We invite contributions that investigate the role of genetic variants, gene–environment interactions, and epigenetic factors in the pathophysiology of ICH. The scope includes, but is not limited to, studies on hereditary bleeding disorders, vascular malformations, and the influence of genetic polymorphisms on clinical outcomes. We encourage interdisciplinary approaches that integrate genetic research with clinical insights to provide a holistic perspective on ICH.

Historically, the genetics of intracranial hemorrhage has been an underexplored area within neurology and genetics. Traditional studies focused primarily on environmental factors and clinical risk factors, often overlooking the potential contributions of genetic predisposition. However, with advancements in genetic research methodologies, including genome-wide association studies (GWAS) and next-generation sequencing, there is a growing recognition of the importance of genetic factors in ICH. This Special Issue aims to build upon this evolving landscape by presenting cutting-edge research that bridges the gap between genetics and clinical practice in the field of intracranial hemorrhage.

This Special Issue will feature cutting-edge research that showcases innovative methodologies and findings in the genetics of ICH. We aim to include studies that utilize advanced genomic techniques, such as whole-genome sequencing, transcriptomics, and epigenomic profiling, to uncover novel genetic risk factors associated with ICH. Additionally, we welcome research that explores the interactions between genetic and environmental factors, as well as studies that investigate the biological mechanisms through which genetic variations contribute to the pathogenesis of ICH. By spotlighting these advancements, we hope to stimulate further research and collaboration in this vital area of study.

We invite original research articles, reviews, and case studies that contribute to the understanding of the genetics of intracranial hemorrhage. Specifically, we seek the following:

• Original research articles that present novel findings related to genetic associations with ICH.
• Reviews that summarize current knowledge on the genetic mechanisms underlying ICH and propose future research directions.
• Case studies that highlight unique genetic profiles in patients with ICH, providing insights into clinical implications and management strategies.

Methodological papers that showcase innovative approaches to studying the genetics of ICH, including data analysis techniques and experimental designs. Through this Special Issue, we aim to create a platform that fosters dialogue and collaboration among researchers, clinicians, and geneticists to advance our understanding of intracranial hemorrhage from a genetic perspective.

Dr. Marialuisa Zedde
Dr. Rosario Pascarella
Guest Editors

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