Chromatin Remodeling and DNA Repair Pathways in Cancer
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".
Deadline for manuscript submissions: 25 October 2025 | Viewed by 69
Special Issue Editor
Special Issue Information
Dear Colleagues,
Chromatin remodeling is a dynamic process critically regulating many cellular events such as DNA transcription, replication, and repair through facilitating the binding of regulatory factors to specific DNA sequences. The mechanism of chromatin remodeling is dependent upon three dynamic characteristics of nucleosomes consisting of (1) reconstruction, (2) enzyme-induced covalent modification, and (3) repositioning. Chromatin remodelers, which are large chromatin-remodeling complexes, utilize ATP hydrolysis to alter nucleosome composition and chromatin packaging; this creates open chromatin structures that allow access to DNA repair proteins, which necessitate DNA damage repairs (DDRs) and DNA repair pathway choice. For instance, chromatin remodelers, typically ATPase-dependent complexes, can collaborate with epigenetic readers or modifying enzymes in an acetylation- or poly(ADP-ribosyl)ation (PARylation)-dependent manner to regulate DSB repair by contributing to chromatin decompaction. On the other hand, increasing evidence suggests that DSBs can induce nucleosome remodeling. For example, following DSBs, ADP-ribosylation (ADPr) is transiently induced to augment chromatin relaxation, which enhances accessibility for DNA repair factors.
Although the functional interaction between DDRs and chromatin remodeling has been extensively studied, it is not fully elucidated. Therefore, this Special Issue aims to further explore the novel mechanisms underlying how chromatin remodeling regulates DDRs and how DDRs regulate chromatin remodeling.
We welcome original research papers, comprehensive reviews, and/or letters that shed light on the mechanisms elucidating the functional interactions between chromatin remodeling and DDRs.
Dr. Manh Tien Tran
Guest Editor
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Keywords
- chromatin remodeling
- chromatin remodelers
- nucleosome
- histone modification
- DNA damage responses
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