Physics and Chemistry of Radiation Damage to DNA and Its Consequences
A special issue of DNA (ISSN 2673-8856).
Deadline for manuscript submissions: 30 June 2025 | Viewed by 8753
Special Issue Editor
Interests: radiation chemical mechanisms of DNA damage; aminyl radical chemistry, reduction of azides; minor groove-ligands; bisbenzimidazoles; nanoceria; radiation chemistry; ESR spectroscopy; pulse radiolysis; ion-radicals; charge transfer in DNA and proteins
Special Issue Information
Dear Colleagues,
Genetic information in living systems is stored in DNA molecules consisting of nucleobases (pyrimidines and purines), sugar (deoxyribose), and phosphate. The information processing necessary for various functions is carried out through the genetic code, determined by the base sequence. Therefore, any perturbation in the structure of DNA molecules profoundly affects the performance and survival of living organisms. Experimental evidence indicates that damage to DNA molecules is the most important cause of cell death, mutation, and transformations induced by ionizing radiation. Studies are being undertaken to further our understanding of the various mechanisms underlying DNA damage and its repair in cells as this knowledge can serve as a basis for predicting the shapes and slopes of the dose–response curves of biological effects induced by different types of radiation (high LET or low LET) and dose rates (FLASH). As such, our aim should be to develop radioprotectors to prevent radiation-induced injuries to healthy tissues and radiosensitizers to enhance damage to cancer cells, which may lead to improvements in radiotherapy protocols, enabling a high likelihood of cure without any significant morbidity to be achieved at non-toxic concentrations of radiomodifiers. The development of effective and non-toxic radiomodifiers is also of interest for space flights, the nuclear industry, and the prevention of radiation accidents. The following Special Issue aims to address the physical, physicochemical, and biochemical events involved in radiation-mediated DNA and RNA damage formation and its biochemical processing, including the role of epigenetics, radiomodifiers, and cancer therapeutics.
Submissions made to this Special Issue of the journal DNA may include papers covering the following topics:
- Track structure calculations, applications in DNA damage formation, and its effects on DNA, nucleohistones, cells, tissues, etc.
- The chemistry of DNA damage leading to the formation of various types of lesions as a result of different quantities of radiation and the effect of dose rate.
- Influence of the environment (hydration, oxygen, proteins, bound molecules, temperature) on lesion formation.
- The role of epigenetics
- Processing DNA lesions and their consequences in repair.
- Radiosensitizers and radioprotectors.
- The role of nanoparticles.
- Tumor radiotherapy
Prof. Dr. Amitava Adhikary
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. DNA is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- DNA damage
- radiation
- track structure
- Monte Carlo models
- linear energy transfer
- charge transfer processes
- free radicals
- low-energy electrons
- base damage
- sugar damage
- strand breaks
- clustered lesions
- tandem lesions
- DNA repair
- radiosensitizers and radioprotectors
- nanoparticles
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.