Physics and Chemistry of Radiation Damage to DNA and Its Consequences
A special issue of DNA (ISSN 2673-8856).
Deadline for manuscript submissions: 31 December 2024 | Viewed by 5916
Special Issue Editor
Interests: radiation chemical mechanisms of DNA damage; aminyl radical chemistry, reduction of azides; minor groove-ligands; bisbenzimidazoles; nanoceria; radiation chemistry; ESR spectroscopy; pulse radiolysis; ion-radicals; charge transfer in DNA and proteins
Special Issue Information
Dear Colleagues,
The genetic information in living systems is stored in DNA molecules consisting of nucleobases (pyrimidines and purines), sugar (deoxyribose), and phosphate. The information processing necessary for various functions is carried out through the genetic code, determined by the base sequence. Therefore, any perturbation in the structure of DNA molecules profoundly affects the performance and survival of living organisms. Experimental evidence indicates that damage to DNA molecules is the most important cause of cell death, mutation and transformations induced by ionizing radiation. Studies are being undertaken to further our understanding of the various mechanisms underlying DNA damage and its repair in cells, since this knowledge can serve as a basis for predicting the shapes and slopes of the dose–response curves of biological effects induced by different types of radiation (high LET, low LET) and dose rates (FLASH). Thus, we should develop radioprotectors to prevent radiation injuries to normal tissues and radiosensitizers to enhance damage in the cancer cells, which may lead to improvements in radiotherapy protocols so that a high probability of cure without any significant morbidity can be achieved at non-toxic concentrations of radiomodifiers. The development of effective and non-toxic radiomodifiers is also of interest for space flights, nuclear industries and radiation accidents.
Keeping this in mind, during the ACS CERM 2022 meeting (EMU, Ypsilanti), Prof. Amitava Adhikary (Chemistry Department, Oakland University) is organizing a symposium entitled "Physics and Chemistry of Radiation Damage to DNA and its consequences (oral)" on 7th June. This symposium presents the current knowledge on this topic, starting from physical, physicochemical, and biochemical events involved in radiation-mediated DNA and RNA damage formation, and its biochemical processing, including the role of cerium oxide nanoparticles as effective radiomodifiers.
A Special Issue of the journal DNA (MDPI) will emerge from this symposium. Topics in this Special Issue may include:
- Track structure calculations, applications in DNA damage formation and its effects on DNA, nucleohistones, cells, tissues, etc.
- Chemistry of DNA damage leading to various types of lesion formation by radiation of different qualities and the effect of dose rate.
- Influence of the environment (hydration, oxygen, proteins, bound molecules, temperature) on lesion formation.
- Processing DNA lesions and their consequences in repair.
- Radiosensitizers and radioprotectors.
- Roles of nanoparticles.
Prof. Dr. Amitava Adhikary
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Planned Papers
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: The Role of a post-transcriptional modification in the modulation of oxidative damage to RNA
Authors: Immaculate Sappy; Razuya Shaik; Saad Alqarni; Akirmah; Matthew Starr; Jessica Groenevelt; Mel Bedi; Amanda Bryant-Friedrich
Affiliation: Wayne State University
Abstract: The Role of a post-transcriptional modification in the modulation of oxidative damage to RNA
Title: Epigenetic Alterations Induced by Ionizing Radiation: Pathways to Cancer and Prognostic Strategies
Authors: Ashok Sharma; et al.
Affiliation: Laboratory of Chromatin and Cancer Epigenetic Room No: 3029, Department of Biochemistry, National Cancer Institute-India, Jhajjar Campus
Abstract: Epigenetic Alterations Induced by Ionizing Radiation: Pathways to Cancer and Prognostic Strategies
Title: Unraveling Deubiquitinating Enzymes Role in DNA Damage Repair: Implications for Colorectal Cancer Therapy
Authors: Fahika Nazeerulla; Vaibhaav Pranay; Sukeerthi Dasharathy; Ekta Tripathi; Prashanthi Karyala; Rao VL Papineni
Affiliation: 1 Ramaiah University of Applied Sciences, Bangalore, India
2 PACT & Health, Branford, CT; 3 University of Kansas KUMC, USA
Abstract: Unraveling Deubiquitinating Enzymes Role in DNA Damage Repair: Implications for Colorectal Cancer Therapy