Special Issue "Dermatopathology and COVID-19"

A special issue of Dermatopathology (ISSN 2296-3529).

Deadline for manuscript submissions: 15 December 2022 | Viewed by 4847

Special Issue Editor

Prof. Dr. Gürkan Kaya
E-Mail Website
Guest Editor
1. Department of Dermatology, University Hospital of Geneva, 1205 Geneva, Switzerland
2. Department of Clinical Pathology, University Hospital of Geneva, 1205 Geneva, Switzerland
Interests: molecular pathology of skin aging and dermatoporosis; clinicopathological correlation in inflammatory dermatoses; pathology of melanocytic lesions; molecular dermatopathology; dermatotoxicopathology
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Special Issue Information

Dear Colleagues,

With the growing number of cases with skin manifestations related to COVID-19, we have decided to dedicate a Special Issue to this subject. This Special Issue aims to cover these cutaneous lesions, which may be quite diverse. The major clinical forms described were maculopapular eruptions, acral areas of erythema with vesicles or pustules (pseudochilblain), urticarial lesions, other vesicular eruptions, and livedo or necrosis. The histopathological features of these lesions also vary, corresponding to the diversity of clinical manifestations. These features underline the nature of epidermal and dermal vascular lesions—and in severe cases, microvascular injury and thrombosis—associated with COVID-19 and provide important clues to their pathological mechanisms.

Prof. Dr. Gürkan Kaya
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Dermatopathology is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • skin lesions
  • COVID-19
  • SARS-CoV-2
  • histopathology

Published Papers (4 papers)

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Research

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Article
Single-Center Clinico-Pathological Case Study of 19 Patients with Cutaneous Adverse Reactions Following COVID-19 Vaccines
Dermatopathology 2021, 8(4), 463-476; https://doi.org/10.3390/dermatopathology8040049 - 27 Sep 2021
Cited by 9 | Viewed by 1909
Abstract
(1) Background: Coronavirus disease 2019 (COVID-19) vaccines are currently employed on a population-wide scale in most countries worldwide. Data about unusual cutaneous adverse drug reactions (ADR) are scant, though. (2) Methods: We retrospectively analyzed moderate to severe vaccine-related ADR in the Department of [...] Read more.
(1) Background: Coronavirus disease 2019 (COVID-19) vaccines are currently employed on a population-wide scale in most countries worldwide. Data about unusual cutaneous adverse drug reactions (ADR) are scant, though. (2) Methods: We retrospectively analyzed moderate to severe vaccine-related ADR in the Department of Dermatology and Allergy of the University Hospital Bonn between May to June 2021 and analyzed related skin biopsies. (3) Results: As a specialized dermatological academic center, we encountered a total of n = 19 clinically and pathologically heterogeneous cutaneous ADR with a female predominance. Delayed cutaneous ADR occurred as late as 30 days after vaccination. The majority of ADR were mild, though a few patients required systemic treatment (antihistamines, glucocorticosteroids). (4) Conclusions: The clinico-pathological spectrum of cutaneous side effects with COVID-19 vaccines is wide; however, the benefits outweigh the risks by far. More dermatopathological studies on cutaneous ADR not limited to COVID-19 vaccines are desirable to enable a better understanding of underlying pathophysiological mechanisms. Full article
(This article belongs to the Special Issue Dermatopathology and COVID-19)
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Review

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Review
The Impact of COVID-19 Pandemic on Dermatological Conditions: A Novel, Comprehensive Review
Dermatopathology 2022, 9(3), 212-243; https://doi.org/10.3390/dermatopathology9030027 - 29 Jun 2022
Viewed by 948
Abstract
Background: The earliest cases of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China, in December 2019. Since the declaration as a pandemic on 11 March 2020, further dermatological conditions continue to be documented. We herein present a novel literature review [...] Read more.
Background: The earliest cases of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China, in December 2019. Since the declaration as a pandemic on 11 March 2020, further dermatological conditions continue to be documented. We herein present a novel literature review of dermatological manifestations associated with the Coronavirus Disease 2019 (COVID-19) pandemic. To date, this literature review is the first broad-spectrum examination that analyzes a range of dermatological manifestations related to the COVID-19 pandemic: infection, vaccinations, personal protective equipment (PPE), and psychosocial factors. Methods: A detailed literature search was conducted using key terms for cutaneous manifestations associated with the scope of this review. The search retrieved 2199 articles. Results: The COVID-19 pandemic has triggered a significant range of dermatologic sequela. Etiologies of lesions continue to be investigated. Proposed mechanisms include inflammatory response to spike protein, vitamin D deficiency, ACE2 receptor activation, androgen levels, and increased psychological stress. One prominent mechanism describes viral spike protein invasion into the dermis by binding to the angiotensin-converting enzyme 2 (ACE-2) receptors in keratinocytes, with a secondary immunological response. Conclusions: Dermatologists play an integral role in the proper diagnosis and treatment of COVID-related lesions. Early treatment regimens and timely prophylaxis have been shown to safely reduce infection-related dermatological sequelae. Additional investigations and data collection can reduce disease burden and improve overall prognosis. Full article
(This article belongs to the Special Issue Dermatopathology and COVID-19)
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Other

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Case Report
Pityriasis Lichenoides et Varioliformis Acuta as a Complication of COVID-19 Infection
Dermatopathology 2022, 9(3), 244-250; https://doi.org/10.3390/dermatopathology9030028 - 05 Jul 2022
Viewed by 721
Abstract
Pityriasis lichenoides is an acute and/or chronic skin disease associated with recurrent erythematous papules that self-resolve. While its etiology is unknown, preceding viral infection may play a role. We present an atypical case of a 40-year-old woman with pityriasis lichenoides et varioliformis acuta [...] Read more.
Pityriasis lichenoides is an acute and/or chronic skin disease associated with recurrent erythematous papules that self-resolve. While its etiology is unknown, preceding viral infection may play a role. We present an atypical case of a 40-year-old woman with pityriasis lichenoides et varioliformis acuta as a complication of a COVID-19 infection. Full article
(This article belongs to the Special Issue Dermatopathology and COVID-19)
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Case Report
Pseudo-Pemphigoid Gestationis Eruption Following SARS-CoV-2 Vaccination with mRNA Vaccine
Dermatopathology 2022, 9(3), 203-206; https://doi.org/10.3390/dermatopathology9030025 - 24 Jun 2022
Viewed by 616
Abstract
Auto-immune reactions, including auto-immune bullous disease, have been reported following SARS-CoV-2 virus vaccination. Few cases of bullous pemphigoid are described, but there has been no case of pemphigoid gestationis. We report the first case here. Full article
(This article belongs to the Special Issue Dermatopathology and COVID-19)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: The Impact of COVID-19 Pandemic on Dermatological Conditions: A Comprehensive Review
Authors: Gehan A. Pendlebury; Peter Oro; William Haynes; Drew Merideth; Samantha Bartling; Michelle A. Bongiorno
1. Nova Southeastern University, College of Osteopathic Medicine, Fort Lauderdale, FL, USA
2. A.T. Still University, School of Osteopathic Medicine in Arizona, Mesa, AZ, USA
3. Department of Dermatology, Walter Reed National Military Medical Center, Bethesda, MD, USA
Abstract: Background: The earliest cases of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China, in December 2019. Since the declaration as a pandemic on March 11, 2020, further dermatological conditions continue to be documented. We herein present a novel literature review of dermatological manifestations associated with the Coronavirus Disease 2019 (COVID-19) pandemic. To date, this review is the first broad-spectrum COVID-19 literature review that examines a range of dermatological manifestations related to the COVID-19 pandemic: infection, vaccinations, personal protective equipment (PPE), and psychosocial factors. Methods: A detailed literature search was conducted using key terms for cutaneous manifestations associated with the scope of this review. The search retrieved 2,199 articles. Results: SARS-CoV-2 has been associated with dermatological conditions. One prominent mechanism describes viral spike protein invasion into the dermis by binding to the angiotensin-converting enzyme 2 (ACE-2) receptors in keratinocytes, with a secondary immunological response. The literature revealed a vast array of dermatoses associated with the pandemic: infection, vaccinations, personal protective equipment (PPE), and psychosocial factors. Conclusions: As dermatological manifestations emerge, dermatologists play an integral role in proper diagnosis and treatment. Early treatment regimens and prophylaxis may safely reduce infection-related dermatological sequelae. Additional investigations and data collection may reduce disease burden and improve disease prognosis.

Keywords: COVID-19; COVID-19 pandemic, SARS-CoV-2 infection; cutaneous manifestations; COVID arm; pandemic psychosocial stress; personal protective equipment; COVID vaccinations, psychodermatology, teledermatology

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