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Colorants
Special Issues
Luminescent Small Molecules for Biochemistry
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Luminescent Small Molecules for Biochemistry

A special issue of Colorants (ISSN 2079-6447).

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 1453

Special Issue Editors

Dr. Patrycja Stachelek

E-Mail Website
Guest Editor
Department of Chemistry, Durham University, Durham, UK
Interests: molecular photophysics; solar fuels; microscopy; bio-imaging; fluorescent probes
Dr. Joshua Karlsson

E-Mail Website
Guest Editor
School of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne, UK
Interests: molecular photophysics; solar fuels; microscopy; bio-imaging; fluorescent probes

Special Issue Information

Dear Colleagues,

Bio-sensing is critical to medical diagnostics and drug design. The current state of the art techniques in microscopy improve the sensitivity and precision in the detection of analytes, and also help to probe the sub-cellular environment. Luminescent small molecules and nanoparticles (NPs) play a vital role in these developments. The uses of such molecules range from nanomachines for cancer treatment to detection of cellular distress, for example hypoxia.

This Special Issue of Colorants will highlight the range of different applications of luminescent small molecules and NPs for bio-chemical and bio-medical applications. We hope to demonstrate the breadth of potential applications of these systems and the cutting-edge science in this field, including the design, synthesis, photophysical analysis, and bio-imaging.

Dr. Patrycja Stachelek
Dr. Joshua Karlsson
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Colorants is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • luminescence
  • fluorescence
  • phosphorescence
  • photodynamic therapy
  • bio-probes
  • photophysics
  • bio-sensing
  • microscopy

Published Papers (1 paper)

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Research

22 pages, 5537 KiB  
Article
A Study on the Structure, Optical Properties and Cellular Localization of Novel 1,3-Benzothiazole-Substituted BODIPYs
by Olga Kirkilessi, Christina Arapatzi, Heribert Reis, Vassiliki Kostourou, Kyriakos C. Prousis and Theodora Calogeropoulou
Colorants 2024, 3(1), 17-38; https://doi.org/10.3390/colorants3010002 - 31 Dec 2023
Viewed by 867
Abstract
A library of seven novel 1,3-benzothiazole-substituted BODIPY derivatives with tunable optical properties was synthesized. The new fluorescent dyes exhibited bathochromically shifted absorptions (up to 670 nm) and emissions centered in the red and near-infrared spectral region (up to 677 nm) in comparison to [...] Read more.
A library of seven novel 1,3-benzothiazole-substituted BODIPY derivatives with tunable optical properties was synthesized. The new fluorescent dyes exhibited bathochromically shifted absorptions (up to 670 nm) and emissions centered in the red and near-infrared spectral region (up to 677 nm) in comparison to the parent compound 8-phenyl BODIPY (λabs: 499 nm, λemi: 508 nm). (TD)DFT calculations were performed to rationalize the spectroscopic properties of the new dyes. The cellular biodistribution of the new BODIPY dyes, their fluorescence stability and toxicity were investigated in both living and fixed fibroblasts using time-lapse fluorescent imaging and confocal microscopy. Six of the seven new dyes were photostable and non-toxic in vitro at 10 μM concentration. In addition, they efficiently stained the cell membrane, showing diffuse and dotty localization within the cell at low concentrations (1.0 and 0.1 μM). Specifically, dye TC498 was localized in vesicular structures in both live and fixed cells and could be used as a suitable marker in co-staining studies with other commonly used fluorescent probes. Full article
(This article belongs to the Special Issue Luminescent Small Molecules for Biochemistry)
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