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Chemosensors
Special Issues
Electrochemical Sensors Based on Various Materials
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Electrochemical Sensors Based on Various Materials

A special issue of Chemosensors (ISSN 2227-9040). This special issue belongs to the section "Materials for Chemical Sensing".

Deadline for manuscript submissions: 15 March 2026 | Viewed by 464

Special Issue Editors

Dr. Cristiana Eugenia Ana Grigorescu

E-Mail Website
Guest Editor
Optospintronics Department, National Institute for Research and Development in Optoelectronics—INOE 2000, 409 Atomistilor, 077125 Magurele, Romania
Interests: surfaces and interfaces; spectroscopy (Raman, IR, PL, and electrochemical); diagnostics and monitoring of disease treatments; one health; applications of sensors in human; veterinary medicine
Dr. Ana Maria Iordache

E-Mail Website
Guest Editor
Optospintronics Department, National Institute of Research and Development for Optoelectronics (INOE-2000), 077125 Magurele, Romania
Interests: electrochemistry; gas sensors; biosensors; environmental protection
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The continuous development of society brings new challenges worth tackling. The electroctrochemical sensors offer the possibility to detect and quantify different types of molecules (both inorganic and organic) at ppm levels in different environments. An example of this is the use of both natural and synthetic (i.e., simulated experiments) conductive polymers for the assessment of biological molecules (histamine, cortisol, etc.) in human fluids.

This Special Issue aims to cover both reviews and original research articles exploring different sensors that are used for the detection of electroactive species. Here, we are focusing on recent innovations in electrochemical analysis of materials in aqueous/non-aqueous solutions.

We look forward to your submissions.

Dr. Cristiana Eugenia Ana Grigorescu
Dr. Ana Maria Iordache
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Chemosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • carbon-based electrochemical sensors (graphene/fullerene/CNT, etc.)
  • materials for elecrochemical biosensors
  • conductive polymers for sensitive detection of pollutants
  • electrochemical detection of biological components
  • lock-and-key electrochemical sensors
  • molecular imprinted polymers

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Published Papers (1 paper)

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Research

19 pages, 2271 KB  
Article
Plasmonic Nanopore Sensing to Probe the DNA Loading Status of Adeno-Associated Viruses
by Scott Renkes, Steven J. Gray, Minjun Kim and George Alexandrakis
Chemosensors 2025, 13(12), 418; https://doi.org/10.3390/chemosensors13120418 - 4 Dec 2025
Viewed by 229
Abstract
Adeno-associated viruses (AAVs) are a leading vector for gene therapy, yet their clinical utility is limited by the lack of robust quality control methods to distinguish between empty (AAVempty), partially loaded (AAVpartial), and fully DNA loaded (AAVfull) [...] Read more.
Adeno-associated viruses (AAVs) are a leading vector for gene therapy, yet their clinical utility is limited by the lack of robust quality control methods to distinguish between empty (AAVempty), partially loaded (AAVpartial), and fully DNA loaded (AAVfull) capsids. Current analytical techniques provide partial insights but remain limited in sensitivity, throughput, or resolution. Here we present a multimodal plasmonic nanopore sensor that integrates optical trapping with electrical resistive-pulse sensing to characterize AAV9 capsids at the single-particle level in tens of μL sample volumes and fM range concentrations. As a model system, we employed AAV9 capsids not loaded with DNA, capsids loaded with a self-complementary 4.7 kbp DNA (AAVscDNA), and ones loaded with single-stranded 4.7 kbp DNA (AAVssDNA). Ground-truth validation was performed with analytical ultracentrifugation (AUC). Nanosensor data were acquired concurrently for optical step changes (occurring at AAV trapping and un-trapping) both in transmittance and reflectance geometries, and electrical nanopore resistive pulse signatures, making for a total of five data dimensions. The acquired data was then filtered and clustered by Gaussian mixture models (GMMs), accompanied by spectral clustering stability analysis, to successfully separate between AAV species based on their DNA load status (AAVempty, AAVpartial, AAVfull) and DNA load type (AAVscDNA versus AAVssDNA). The motivation for quantifying the AAVempty and AAVpartial population fractions is that they reduce treatment efficacy and increase immunogenicity. Likewise, the motivation to identify AAVscDNA population fractions is that these have much higher transfection rates. Importantly, the results showed that the nanosensor could differentiate between AAVscDNA and AAVssDNA despite their identical masses. In contrast, AUC could not differentiate between AAVscDNA and AAVssDNA. An equimolar mixture of AAVscDNA, AAVssDNA and AAVempty was also measured with the sensor, and the results showed the expected population fractions, supporting the capacity of the method to differentiate AAV load status in heterogeneous solutions. In addition, less common optical and electrical signal signatures were identified in the acquired data, which were attributed to debris, rapid entry re-entry to the optical trap, or weak optical trap exits, representing critical artifacts to recognize for correct interpretation of the data. Together, these findings establish plasmonic nanopore sensing as a promising platform for quantifying AAV DNA loading status and genome type with the potential to extend ultra-sensitive single-particle characterization beyond the capabilities of existing methods. Full article
(This article belongs to the Special Issue Electrochemical Sensors Based on Various Materials)
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