Microarray-Based Platforms and Strategies for the Development of Molecular-Centric Diagnostic Tools
A special issue of BioTech (ISSN 2673-6284).
Deadline for manuscript submissions: closed (31 July 2015) | Viewed by 204
Special Issue Information
Dear Colleagues,
The heterogeneous and sometimes overlapping presentation in complex diseases can result in an inability to provide a timely and definitive diagnosis. The clinical practices of gastroenterology (e.g., in the case of Crohn’s disease versus ulcerative colitis) and urology (e.g., in the case of interstitial cystitis versus bladder pain syndrome) offer but two examples among many wherein it is not always possible to provide a clear discrimination between two similar disease presentations. Assessing disease stage or disease progression (e.g., in Parkinson’s disease) can present a similar challenge. These diagnostic ambiguities can ultimately result in less than optimal treatment strategies and, therefore, less than optimal outcomes. In this era of developing a more personalized approached to patient care, the discovery of additional robust (i.e., both sensitive and specific) diagnostic tools to assist the clinician is an absolute priority.
Molecular profiling—specifically those approaches that employ microarray-based platforms—of both patient-derived disease tissues, and also peripheral tissues (e.g., blood, urine, CSF), provides the research community with a formidable set of technologies to bring to bear for the development of these new clinical diagnostic tools. This special issue focuses on all aspects of microarray-based biomarker development for the diagnosis, monitoring, and treatment of complex disease. The issue will emphasize the various microarray-based approaches currently in use across a variety of diseases.
Dr. Stephen J. Walker
Guest Editor
Manuscript Submission Information
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Keywords
- microarray
- biomarker
- diagnostic
- peripheral biomarker
- personalized medicine
- classifiers
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