Immunotherapy for Renal Cell Carcinoma
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".
Deadline for manuscript submissions: closed (15 June 2022) | Viewed by 381
Special Issue Editors
Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA
Interests: renal cell carcinoma; immune environment; genomics
Interests: renal cell carcinoma; immune environment; genomics
Special Issue Information
Renal cell carcinoma (RCC) is a heterogeneous disease with at least 16 histopathological subtypes identified to date. Recent genomic data have demonstrated high molecular heterogeneity in renal cell carcinoma (RCC) .The pathophysiology of RCC is complex and arises from a combination of gene mutations (i.e., VHL, PBMR1, SETD2, BAP1, etc.) in addition to other factors such as diabetes, obesity, smoking, and hypertension. The current backbone for the treatment of renal cell carcinoma (RCC) includes VEGF inhibitors, mTOR inhibitors and checkpoint inhibitors (CPI) targeting PD/PD-L1 and CTLA4. In the past few years, the combination of VEGF inhibitors and CPI have shown significant improvement in the outcomes of RCC. Additionally, the role of HIF inhibitors is evolving and is being evaluated in numerous
clinical trials. The aim of this Special Issue is to provide a comprehensive overview of the impact of RCC development and progression by considering their association with key features of RCC, namely microenvironment, drug resistance, metabolism, angiogenesis, metastatic process, and immune response.
clinical trials. The aim of this Special Issue is to provide a comprehensive overview of the impact of RCC development and progression by considering their association with key features of RCC, namely microenvironment, drug resistance, metabolism, angiogenesis, metastatic process, and immune response.
Keywords
- renal cell carcinoma
- antiangiogenic agents
- tumor immune microenvironment
- inflamed tumor
- immunotherapy
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