Local and Targeted Therapies in Glioblastoma Multiforme
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".
Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 298
Special Issue Editor
2. Medical School, University of Münster, Münster, Germany
3. Medical School, University of Nicosia, Nicosia, Cyprus
Interests: glioblastoma multiforme; brain and spinal tumours; neuroimmunology; molecular biology, i.e. intracellular signaling & nucleocytoplasmic transport
Special Issue Information
Dear Colleagues,
The current therapeutic regimen for glioblastoma multiforme (GBM) seems rather ineffective, since the survival of patients suffering from GBM averages less than two years. The poor prognosis and resistance to treatment may be predominantly attributed to the blood-brain barrier (BBB), which hinders a sufficient intra-tumoral concentration of the chemotherapeutic agents and, thus, mitigates the effect of their systemic delivery. Alternative methods to overcome the BBB and lessen the systemic drug toxicity are definitely needed.
To this end, several techniques for more effective drug delivery are being studied in the context of early phase clinical trials, such as selective intra-arterial, intra-nasal, and intra-tumoral approaches, as well as targeted therapy via use of nanoparticles or autologous vaccines. Further procedures aim towards a temporary modification of the BBB, such as focused ultrasound, whereas others, such as photodynamic therapy or thermal therapy approaches have a direct destructive impact on the tumor cells.
The purpose of this Special Issue is the comprehensive report of promising novel methods and substances that can be used either for a more efficient drug delivery escaping the BBB, or for a direct local treatment of the tumor cavity, and could potentially contribute to an improved outcome of patients with GBM.
Prof. Dr. Konstantinos Gousias
Guest Editor
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Keywords
- glioblastoma multiforme
- blood-brain barrier
- targeted drug delivery
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