Neuropathology: Understanding Local and Systemic Influence of Disease and Vice-Versa

Dear Colleagues,

Advances in science and medicine have uncovered a wide spectrum of brain pathologies including traumatic brain injury, hypoxic or hypobaric insults, hemorrhages, stroke, and neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Any pathology of the brain is multifactorial and initiates a cascade of processes including, but not limited to, inflammation, cell death, repair, regeneration, and chronic neurodegeneration. It has long been known to us that insult or injury to brain may lead to neurological disorders such as Alzheimer’s and Parkinson’s disease as time elapses, and genetic or environmental factors play important roles in the progression of disease. A large body of evidence has shown that oxidative stress, mitochondrial dysfunctions, protein aggregation and phosphorylation, excessive iron accumulation in the brain, and neuro-inflammation play a pivotal role in neurodegeneration and brain injuries.

Crucially, brain pathology is not restricted to the CNS. It both shapes and is shaped by the function of peripheral organs, underscoring the importance of studying neurological disease through a holistic and systems-level understanding. Yet, despite decades of research, no definitive cure exists to halt or slow these progressive conditions. This has fueled the scientific community’s drive to unravel the mechanisms behind these pathological cascades and to pioneer novel preventive and therapeutic approaches.

This Special Issue aims to serve as a multidisciplinary forum to explore the pathology, mechanisms, and interventions in brain disorders. We welcome contributions that address psychological, behavioral, inflammatory, and molecular drivers of neurodegeneration, as well as innovative strategies to prevent or treat brain injuries and neurological disease. Submissions examining the bidirectional influence between brain and peripheral systems are particularly encouraged. High-quality original research articles and reviews that have not been either published or submitted elsewhere are invited. We look forward to your contributions and to advancing this critical conversation together.

Potential topics include, but are not limited to, the following:

• Brain pathologies: Insight into systemic influence;
• Systemic and localized cellular influence on brain pathologies;
• Models and Innovation in Neurological diseases;
• Molecular and histological alterations in an injured brain;
• Behavioral changes in an injured brain;
• Hypoxic brain injury and the role of vasculature;
• Traumatic brain injury: mechanism and prevention;
• Brain injury: emotional and psychological stress;
• Parkinson’s and Alzheimer’s disease;
• Neurodegeneration: does it link to previous brain injury?
• COVID-19: are brain pathologies involved?
• Brain insult and cognitive impairment;
• Intracerebral hemorrhages and hypoxia;
• Stroke-induced molecular and functional alterations;
• Prevention of brain insult by natural molecules and pharmaceuticals;
• Bioanalytical studies and receptor-mediated mechanism of natural compounds for the prevention of different kind of brain injuries;
• Mechanisms of action of pharmaceuticals and natural products targeting oxidative stress and neuroinflammation in injured brain;
• Computational and genetic studies of brain injuries;
• Brain injury: protein misfolding and mitochondrial dysfunction;
• Gut-brain axis;
• Microbiomes in brain health;
• Lungs and brain;
• Cardiovascular aspect of brain pathologies;
• Liver and brain;
• Stem cells therapy in brain pathologies;
• Genomic studies in brain;
• Immune interactions in brain pathologies;
• Immunosenescence and ageing;
• Depression, bipolar disorder, and schizophrenia;
• Stem cells in brain disorder;
• Bone marrow response in brain pathologies;
• Erythropoiesis in brain disorders;
• Myeloid and lymphoid organs in brain pathologies;
• Innate lymphoid cells;
• Meningeal response to disease;
• Dementia, Parkinson’s disease as neurodegeneration;
• Metal toxicity in brain pathologies;
• Alternative medicines and therapies in Neurological disorders.

Dr. Kumar Vaibhav
Dr. Pankaj Gaur
Dr. Meenakshi Ahluwalia
Dr. Pankaj Ahluwalia
Dr. Shashi Nandar Kumar
Guest Editors

Manuscript Submission Information

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• brain pathologies
• brain injury
• Parkinson’s disease
• Alzheimer’s disease
• stroke
• neurodegeneration
• hemorrhages
• hypoxia
• neuroinflammation
• translational approaches
• oxidative stress
• COVID-19
• gut–brain axis
• systemic influence
• immune interaction
• synaptic plasticity
• ageing
• senescence
• bone marrow and neuropathology
• pesticides, preservatives and environmental contamination
• lungs and brain
• liver and brain
• cardiovascular effect of brain pathology and vice-versa
• acute and chronic neuro-immune interaction
• therapeutic strategies and intervention
• alternative medicines in brain pathologies