Mechanisms and Modulation in Cardiovascular Disease: From Inflammation to CHIP
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: closed (31 May 2024) | Viewed by 375
Special Issue Editor
Special Issue Information
Dear Colleagues,
For a long time, atherosclerosis has been regarded as a mere lipid deposit in the blood vessels. However, in recent years, a growing body of experimental and clinical evidence has highlighted the role of inflammation and immunity as a central mechanism of disease. Moreover, in the last decade, next-generation sequencing and its application to a large human population has broken the barrier between inflammation and cancer. Indeed, acquired mutation in key genes related to the control of hematopoiesis and myeloproliferation has paved the way to the new concept of clonal hematopoiesis of indeterminate potential. This phenomenon is considered not “indeterminate” but as an emerging cardiovascular risk factor. Thus, this may explain the mechanisms of myeloproliferation and inflammation in atherothrombosis. In a bidirectional journey, it has helped to explain the extremely high cardiovascular risk in cancer survivors, in particular in myeloproliferative neoplasm patients.
A deeper understanding of these mechanisms may pave the way for future early diagnosis and potential pre-emptive treatments of the leading cause of death worldwide.
Dr. Santiago Redondo
Guest Editor
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Keywords
- atherosclerosis
- inflammation
- bone marrow
- clonal hematopoiesis
- myeloproliferative neoplasm
- autoimmunity
- cardiovascular risk
- cardio-oncology
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