Stem Cell Research and Bioinformatics in Regenerative Medicine
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Biomedical Engineering and Materials".
Deadline for manuscript submissions: 30 July 2024 | Viewed by 381
Special Issue Editors
2. Department of Medicine I Molecular Cardiology, Klinikum Rechts der Isar—Technical University Munich, Ismaninger Strasse 22, Munich, Germany
Interests: identification and characterization of the molecular and cellular pathophysiological mechanisms associated with the development of lung, endometrial, colon, and ovarian cancer; use of induced pluripotent stem cells as a model for the dissection of the molecular mechanisms governing either the maintenance of pluripotency or cellular transitions during cardiogenesis for the study of congenital heart disease; development of analysis pipelines associated with single-cell next-generation sequencing and integration of biological-omic data
Interests: dissecting the molecular mechanisms involved in the maintenance of pluripotency of induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs), and those governing cellular transitions during pancreatic ontogeny and cardiogenesis. Particular attention is paid to human cardiac progenitors able to mediate heart regeneration; development of iPSC-derived disease models; single-cell transcriptome analysis to identify and characterize cancer stem cells in different tumor types
Special Issue Information
Dear Colleagues,
Regenerative processes require a well-orchestrated integration of the complex biological and molecular events to restore or establish normal function of tissue or organs. With recent scientific discoveries opening up new approaches to regenerative medicine, the challenge is to use these to extend the regenerative approach to major untreatable diseases and conditions. Indeed, regenerative approaches include genome editing or gene therapy, trans-differentiation or in vivo reprogramming, cell therapy and transplantation, 3D bioprinting, organoids or use of combined products.
The application of multi-omics sequencing technologies at the genome, transcriptome and epigenome levels could help to precisely identify the mechanisms and potential molecules to improve the performance of stem cells and their derivatives with therapeutic properties in the treatment of a variety of diseases.
This Special Issue aims to focus on new discoveries about regenerative processes through multi-omics techniques and stem cell-based therapies for human diseases towards the ultimate goal of addressing unmet clinical needs.
Authors are welcome to submit both original research articles and review articles that cover the following topics:
- Stem cell-mediated tissue regeneration and disease modelling;
- Stem cell differentiation approaches and mechanisms;
- Application of bioinformatics methods in tissue regeneration;
- Combination of the stem cells and other therapy.
Dr. Gianluca Santamaria
Dr. Maria Teresa De Angelis
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- stem cells
- tissue repair and regeneration
- genome editing
- 3D bioprinting
- organoids
- single-cell transcriptome profiling
- bioinformatics
