Targeted Biologic Therapies for Allergic Conditions: From Bench to Bedside

Dear Colleagues,

Allergic diseases such as atopic dermatitis, allergic rhinitis, and asthma remain major global health burdens, with  heterogeneous clinical phenotypes and complex immunopathology challenging the development of effective therapies. The advent of biologics has revolutionized treatment strategies, allowing precision targeting of cytokines, cell surface receptors, immune checkpoints, and signaling pathways. However, many clinical gaps remain: identifying which patients benefit most, understanding sex- and gender-specific mechanisms of pathogenesis, overcoming resistance or loss of response, integrating biologics with conventional therapies, and expanding indications beyond asthma and eczema.

This Special Issue of Biomedicines aims to attract contributions that bridge fundamental immunology and translational medicine, with a focus on novel biologic strategies in allergic disease. We welcome high-quality original research and review articles on topics including, but not limited to, novel biologic biomarkers and predictors of response, personalized endotypes, safety and immunogenicity challenges, combinations with small molecules or immunotherapies, and applications in underexplored areas (e.g. professional allergies, food allergies, chronic urticaria). We hope this collection will serve allergists, dermatologists, immunologists, and translational scientists alike by fostering cross-disciplinary insights and accelerating the next wave of biologic innovation in allergic diseases.

Dr. Antonio Francesco Maria Giuliano
Prof. Dr. Maria Teresa Ventura
Guest Editors

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