Advances in Type 2 Diabetes: Insulin Regulation and Therapeutic Strategies

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 762

Special Issue Editor


E-Mail Website
Guest Editor
College of Biomedical Sciences, Larkin University, 18301 N Miami Ave, Miami, FL 33169, USA
Interests: medical chemistry; drug development; formulations; chemical analysis; bioactivity; natural products; chirality; nanotechnology; material sciences
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We invite researchers, clinicians, and healthcare professionals to submit their work to this Special Issue on Advances in Type 2 Diabetes: Insulin Regulation and Therapeutic Strategies. Type 2 diabetes mellitus, T2DM, is a multifaceted metabolic disease characterized by insulin resistance and impaired insulin secretion, leading to chronic hyperglycemia and heightened vulnerability to complications. Despite tremendous advances in understanding its pathophysiology, T2DM remains a significant worldwide dilemma for healthcare, and advancements in therapeutic approaches are urgently required.

This Special Issue will cover the recent developments in insulin regulation, novel pharmacological treatments, and emerging technologies to enhance glycemic control and reduce disease progression. We invite the submission of manuscripts on topics including, but not limited to, Glucagon-Like Peptide-1 (GLP-1) receptor agonists, Sodium–Glucose Cotransporter 2 (SGLT2) inhibitors, novel insulin analogs, non-insulin treatments, artificial intelligence-based diabetes management, and precision medicine approaches.

Contribute to the future of T2DM treatment by submitting original research, comprehensive reviews, and clinical studies to this Special Issue covering significant challenges and new approaches in diabetes treatment.

Prof. Dr. Syed A. A. Rizvi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • type 2 diabetes
  • insulin regulation
  • glycemic control
  • insulin resistance
  • therapeutic strategies
  • personalized medicine
  • GLP-1 receptor agonists
  • SGLT2 inhibitors
  • novel insulin formulations
  • non-insulin therapies

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

24 pages, 3442 KB  
Review
Complementary Yet Distinct Roles of GLP-1 Receptor Agonists and SGLT2 Inhibitors in Cardiovascular Risk Reduction
by Nóra Homoródi, Éva Varga, Zoltán Szabó, Ferenc Sztanek and Mariann Harangi
Biomedicines 2025, 13(11), 2595; https://doi.org/10.3390/biomedicines13112595 - 23 Oct 2025
Viewed by 476
Abstract
Novel antidiabetic drugs introduced in the last decade have not only revolutionized the treatment of type 2 diabetes mellitus but have also changed our cardiovascular risk reduction strategy. Glucagon-like peptide-1 (GLP-1) receptor agonists reduce the risk of atherosclerotic diseases primarily through their complex [...] Read more.
Novel antidiabetic drugs introduced in the last decade have not only revolutionized the treatment of type 2 diabetes mellitus but have also changed our cardiovascular risk reduction strategy. Glucagon-like peptide-1 (GLP-1) receptor agonists reduce the risk of atherosclerotic diseases primarily through their complex anti-atherosclerotic effect due to their endothelial function-improving, anti-inflammatory, anti-thrombotic, and plaque-stabilizing effects. Sodium–glucose cotransporter 2 (SGLT2) inhibitors, on the other hand, have a favorable cardiovascular effect, mainly by increasing sodium excretion, reducing plasma volume, enhancing the use of ketone bodies as metabolic substrates in heart and kidney tissues, and reducing oxidative stress and uric acid serum levels. However, when using these two groups of drugs, important questions arise. What criteria should be used to decide on the administration of one or the other class of drugs? Which group of agents can be used more effectively to reduce our patients’ cardiovascular risk? What are the possible adverse effects? What can be gained by combining the two drugs? Our objective was to provide a current literature-based and comparative summary on the mechanisms of action, cardiovascular-risk-reducing efficacy, and safety profiles of these two drug classes, with an emphasis on identifying key factors influencing everyday clinical decision-making. Full article
Show Figures

Figure 1

Back to TopTop