Current Challenges and Future Trends in Intracranial Aneurysms: Mechanisms, Biomarkers, and Therapeutic Strategies
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 13
Special Issue Editors
Interests: cerebrovascular disease; intracranial aneurysm; cerebral cavernous malformation; acute ischemic stroke; hemorrhagic transformation; brain injury; endovascular treatment
Special Issue Information
Dear Colleagues,
Intracranial aneurysms (IAs) are a serious cerebrovascular condition that affect approximately 3% of the population, which can lead to a devastating subarachnoid hemorrhage and carry high rates of mortality and morbidity when they occur after a rupture has developed. The diagnosis and treatment of IAs have achieved significant advancements over the decades; however, critical challenges still exist. The biological mechanisms underlying aneurysm formation, growth, and rupture are incompletely understood, which complicates targeted prevention efforts. Robust, validated biomarkers for accurate risk prediction of aneurysm rupture and potential responses to aneurysm growth and treatment are urgent needs, which are essential for guiding personalized management strategies. Optimal treatment strategies with endovascular procedures and surgical clipping, especially for complex or recurrent aneurysms, require further refinement. Novel pharmacological or biological therapies targeting the underlying pathophysiology are needed for innovative solutions in this area.
This Special Issue aims to provide cutting-edge research addressing the latest advancements in the field of intracranial aneurysms, including mechanisms, biomarkers, and therapeutic approaches. It will cover various aspects of this pathology, exploring therapeutic strategies such as endovascular interventions, as well as emerging pharmacological and biological treatments that are driving translational research and ultimately improving patient outcomes. We invite original research articles and comprehensive reviews that enhance our understanding and management of intracranial aneurysms.
Prof. Dr. Zhongsong Shi
Prof. Dr. Aichi Chien
Guest Editors
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Keywords
- intracranial aneurysm
- subarachnoid hemorrhage
- inflammation
- immune
- smooth muscle cell
- endothelial dysfunction
- hemodynamic forces
- biomarkers
- neuroimaging
- non-coding RNA
- multi-omics
- endovascular treatment
- computational fluid dynamic
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