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Infectious Diseases in Respiratory Medicine

A special issue of Advances in Respiratory Medicine (ISSN 2543-6031).

Deadline for manuscript submissions: 26 September 2026 | Viewed by 2432

Special Issue Editor

Dr. Kay Choong See

E-Mail Website
Guest Editor
Division of Respiratory and Critical Care Medicine, Department of Medicine, National University Hospital, Singapore 119228, Singapore
Interests: respiratory infection; intensive care medicine; public health
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to this Special Issue, “Infectious Diseases in Respiratory Medicine”. Infectious diseases continue to represent a major cause of morbidity and mortality worldwide, with respiratory infections ranking among the most common and severe. The recent global experience with COVID-19 has highlighted the critical need for continued research into the diagnosis, treatment, and prevention of respiratory infections. Beyond emerging viral pandemics, bacterial, fungal, and mycobacterial respiratory infections remain highly prevalent, with substantial impact on healthcare systems, patient quality of life, and long-term outcomes. Advancing our understanding in this field is therefore essential for improving patient care and public health.

This Special Issue aims to bring together cutting-edge research and expert perspectives on infectious diseases affecting the respiratory system. It will cover diverse aspects of pathogenesis, diagnostics, therapeutics, and prevention strategies. The focus of this Special Issue aligns closely with the scope of the journal, which emphasizes advances in the understanding and management of respiratory disorders. We expect this collection to be of great interest to clinicians, researchers, and policymakers involved in respiratory and infectious disease medicine.

In this Special Issue, we welcome original research articles, systematic reviews, meta-analyses, and narrative reviews. Research areas may include, but are not limited to, the following themes:

  • Viral respiratory infections (e.g., influenza, SARS-CoV-2, RSV);
  • Bacterial pneumonias and antimicrobial resistance in respiratory medicine;
  • Tuberculosis and non-tuberculous mycobacterial lung disease;
  • Opportunistic infections in immunocompromised hosts;
  • Fungal respiratory infections (e.g., aspergillosis, endemic mycoses);
  • Advances in rapid diagnostics and molecular testing;
  • Vaccines and preventive strategies in respiratory infectious diseases;
  • Host immune response and pathophysiology of respiratory infections;
  • Emerging pathogens and global health perspectives;
  • Infection control and public health implications.

We look forward to receiving your valuable contributions.

Sincerely,
Dr. Kay Choong See
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Advances in Respiratory Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1300 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • respiratory tract infections
  • pneumonia, viral
  • pneumonia, bacterial
  • tuberculosis, pulmonary 
  • mycoses
  • drug resistance, microbial
  • vaccines
  • immunocompromised host 
  • diagnostic techniques and procedures 
  • emerging infectious diseases

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  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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7 pages, 575 KB  
Communication
The Role of L-Arginine and Liposomal Vitamin C Supplementation as an Adjunct in Seasonal Respiratory Viral Infection Recovery
by Valentina Trimarco, Paola Gallo, Seyedali Ghazihosseini, Alessia Izzo, Paola Ida Rozza, Alessandra Spinelli, Stefano Cristiano, Carlo De Rosa, Felicia Rozza and Carmine Morisco
Adv. Respir. Med. 2026, 94(1), 11; https://doi.org/10.3390/arm94010011 - 9 Feb 2026
Viewed by 838
Abstract
Respiratory seasonal viral infections remain one of the most important issues in community medicine. The heterogeneity of etiological agents and the characteristics of the hosts airway antiviral defenses account for the complex management of these infections. The clinical consequence of this picture is [...] Read more.
Respiratory seasonal viral infections remain one of the most important issues in community medicine. The heterogeneity of etiological agents and the characteristics of the hosts airway antiviral defenses account for the complex management of these infections. The clinical consequence of this picture is that, despite the widespread use of vaccination as the primary prevention strategy, the rates of acute respiratory complications remain still high. In addition, they determine post-infectious fatigue and organ dysfunction. Inflammation and oxidative stress are the principal pathogenic mechanisms responsible for clinical complications during respiratory seasonal viral infections. Nowadays, a growing body of evidence indicates that adjunctive nutritional support can contribute to relieve the symptoms during the acute and subacute phases of respiratory viral infections. We assess the data in the literature regarding the combination of L-Arginine and Liposomal Vitamin C as adjuvant treatment for respiratory seasonal viral infections. The database of the National Library of Medicine (PubMed) was searched using the keywords “L-Arginine, Vitamin C, dietary supplements, seasonal respiratory viral infections”. The treatment of symptoms during acute and post-acute respiratory viral infections requires an integrated approach that includes vitamins and nutritional supplementation. The combination of L-Arginine and Liposomal Vitamin C seems to represent a nutritional support able to mitigate symptoms occurring during the acute or post-acute phase of infection. Full article
(This article belongs to the Special Issue Infectious Diseases in Respiratory Medicine)
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Review

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43 pages, 2987 KB  
Review
Clues to Long COVID Linked to Virulence and Infectivity Found in Shell Proteins
by Gerard Kian-Meng Goh, James A. Foster and Vladimir N. Uversky
Adv. Respir. Med. 2026, 94(2), 18; https://doi.org/10.3390/arm94020018 - 11 Mar 2026
Viewed by 1081
Abstract
Clinical, experimental, and computational evidence of COVID-19 virulence and infectivity has been linked to SARS-CoV-2 shell disorder. A strong link was first discovered using an AI disorder-predicting tool, which detected an unusually hard (low disorder) outer shell among all SARS-CoV-2-related viruses but not [...] Read more.
Clinical, experimental, and computational evidence of COVID-19 virulence and infectivity has been linked to SARS-CoV-2 shell disorder. A strong link was first discovered using an AI disorder-predicting tool, which detected an unusually hard (low disorder) outer shell among all SARS-CoV-2-related viruses but not in the 2003 SARS-CoV-1. This could account for the high infectivity found in SARS-CoV-2—but not in SARS-CoV-1—as it is believed that hard shells protect viral particles from the onslaught of the antimicrobial enzymes present in the respiratory system and saliva. As a result, much larger quantities of particles are shed by COVID-19 patients. Abnormally hard outer shells (M) are associated with burrowing animals, e.g., pangolins, and SARS-CoV-2 likely acquired these shells due to its long-term evolutionary interactions with pangolins. As for virulence, the inner shell of SARS-CoV-2 (N) has been found to exhibit lower disorder than that of SARS-CoV-1. This lower disorder is consistent with the fact that SARS-CoV-2 is less virulent than SARS-CoV-1, as higher disorder in the inner shell is associated with more efficient protein–protein binding during replication. The link between N/M disorder and virulence or infectivity falls under the umbrella of shell disorder models (SDMs), which can connect virulence, infectivity, and long COVID under one coherent concept. Evidence of the reliability and reproducibility of SDMs as applied to COVID-19 is examined. The hard M that is resisting the antimicrobial enzymes in the respiratory system can be extended to immunological enzymes, especially those found in phagocytes such as macrophages, which can therefore become a reservoir for the virus. Full article
(This article belongs to the Special Issue Infectious Diseases in Respiratory Medicine)
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