Intracellular Innate Immunity of Antibodies
A special issue of Antibodies (ISSN 2073-4468).
Deadline for manuscript submissions: closed (30 June 2017) | Viewed by 18949
Special Issue Editor
Interests: study of B-cell response to tumors and B-cell interactions with innate immunity in the tumor microenvironment; development and evaluation of affinity reagents for diagnostic and targeted-imaging of cancer and therapy for ovarian cancer
Special Issue Information
Dear Colleagues,
The immune system provides critical protection against pathogens, both through the adaptive immune system, which is highly specific and endowed of memory but slow to develop on first exposure, and the innate immune system, which can immediately sense any intracellular pathogens through the recognition of molecular patterns associated with pathogens (PAMPs) or damaged cells (DAMPs, danger signals, or alarmins) by germline-encoded pattern recognition receptors (PRRs). Cell single sensing can elicit multiple immune responses to efficiently reduce spreading infection. Adaptive immune responses are carried out by activated B and T cells, which produce antigen-specific antibodies or cytotoxic T cells, respectively. Antibodies that patrol the extracellular spaces bind to pathogens, which directly inactivate pathogen functions or prime them for destruction by complement (complement-dependent cytotoxicity, CDC) or phagocytosis (antibody-dependent cell-mediated cytotoxicity, ADCC). In addition to these mechanisms, antibodies also activate intracellular innate immunity when they are carried in the cell during pathogen entry. Once in the cell, pathogen-attached antibodies bind to a cytosolic antibody receptor (Tripartite motif-containing 21, TRIM21) that mediates antibody-dependent intracellular neutralization (ADIN). While ADIN has only been observed to act against adenovirus thus far, it is likely to also be effective against other pathogens. This Special Issue of Antibodies focuses on intracellular innate immunity of antibodies, with specific emphasis on different pathogenic mechanisms, potential therapeutic options and critical information that can be derived from the study of intracellular innate immunity.
Dr. Nathalie Scholler
Guest Editor
Manuscript Submission Information
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Keywords
- PAMPs
- DAMPs
- PRR
- TRIM21
- ADIN
- RIG-I
- MDA5 NF-κB
- AP-1 and IRF signaling pathways
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