Therapeutic Antibodies: New Trends in Discovery, Developability and Characterization
A special issue of Antibodies (ISSN 2073-4468).
Deadline for manuscript submissions: 21 March 2025 | Viewed by 257
Special Issue Editors
Interests: epitope mapping; developability assessment; mode-of-action elucidation; new analytical techniques base on mass spectrometry
Special Issue Information
Dear Colleagues,
The development of therapeutic antibodies has continued its success story in recent years. Every year, around a dozen antibodies are approved by regulatory authorities in the US and EU for the treatment of cancer or other diseases, such as autoimmune diseases. The development pipelines of research-based pharmaceutical companies are well filled. However, there are new trends in the techniques used to discover suitable antibody candidates and test their developability and modes of action. First and foremost is the integration of artificial intelligence and machine learning tools to generate antibodies with tailored properties and predict their developability. High-throughput screening technologies enable researchers to identify the best candidates to take to the next stage of development and use to manipulate biological molecules. High-resolution analytical methods such as affinity chromatography with mass spectrometric detection enable the highly detailed investigation of binding selectivity and a better understanding of the mechanisms of action, thereby building a basis for rational antibody engineering. Highly sensitive analytical techniques such as mass spectrometry-based analysis of host–cell proteins will aid in cell culture development and contribute to a better assessment of drug safety. Lastly, new antibody formats and engineered variants will provide new or improved functionalities.
This Special Issue on therapeutic antibody discovery, development, and characterization will present new technology developments and applications in the field. Researchers will present their latest results, and review articles will cover new developments.
Dr. Anne Zeck
Dr. David J Vance
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibodies is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- antibody lead candidates selection
- epitope prediction and mapping
- developability assessment
- antibody engineering
- mode-of-action elucidation
- host–cell analysis
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