Recent Progress in Human Hippocampus Histological Studies

Dear Colleagues,

It is well known that the hippocampus is one of the most researched regions of the human brain; it is also widely used as a model in studies analyzing a variety of neurological disorders. We are pleased to announce a new Special Issue on Anatomia titled ‘Recent Progress in Human Hippocampus Histological Studies.’ Our Special Issue, along with focusing on the hippocampus sensu stricto (that is, the allocortical brain region made up of dentate gyrus, CA fields CA3, CA2 and CA1, and subiculum) will also expand to the more generic concept “Hippocampal Formation”, as stated previously (Amaral et al., 2023; Insausti and Amaral, 2012), which includes not just the allocortex of the hippocampus sensu stricto but also the immediately adjacent periallocortex (made up of presubiculum, parasubiculum and entorhinal cortex). These two elements, allocortex and periallocortex, form a circuit linked by a largely unidirectional set of connections, from the entorhinal cortex to the dentate gyrus and hippocampus, and back to the entorhinal cortex.

Most hippocampus-related articles are performed in experimental animals. Although, neuroradiological studies have seen an increase in recent years, the number of reports devoted to the human hippocampus is much lower, particularly anatomical studies.

This Special Issue of Anatomia thus intends to bridge this research gap, and focus on the histological correlates of neuroradiologically defined landmarks fields of the hippocampal formation, amygdala and parahippocampal region cortices (temporopolar, perirhinal and parahippocampal cortices) by examining the medial temporal lobe surface, and the histological/neuroradiological appearance in controls, Alzheimer’s disease, and frontotemporal lobar dementia. This Special Issue aims to include research on the procedure for dense histological analysis and its translation to MRI images, and variability in the collateral sulcus (an important landmark in the localization of the parahippocampal region cortices). It will further incorporate studies on hippocampal neuroradiological correlates of persistent COVID-19 which offers an example of pathological changes in a post-viral infection. Additionally, it will include reports on the general overview of the human hippocampal connectivity with other areas of the brain, brainstem innervation of the hippocampus, and macroscopic reports on pig’s hippocampus as a model for anatomical similarity with the human hippocampus.

We hope that this Special Issue will enhance the readers’ understanding of the intricacy of the hippocampus and its applicability to basic and clinical studies.

Dr. Ricardo Insausti
Dr. María del Mar Arroyo Jiménez
Prof. Dr. Paul Yushkevich
Guest Editors

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• human
• hippocampus
• hippocampal formation
• parahippocampal gyrus
• collateral sulcus
• MRI
• histology