Artificial Intelligence for Future Healthcare: Advancement, Impact, and Prospect in the Field of Cancer

A special issue of AI (ISSN 2673-2688). This special issue belongs to the section "Medical & Healthcare AI".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 801

Special Issue Editor


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Guest Editor
Department of Radiology, Memorial Sloan Kettering Cancer Center, 300 East 66th Street (Floor 7), Room 721, New York, NY 10065, USA
Interests: artificial intelligence for workflow optimization and risk prediction; quantitative imaging; blood perfusion quantification; cancer screening devices, and hyperthermia-based cancer treatment strategies

Special Issue Information

Dear Colleagues,

Artificial intelligence (AI) for future healthcare is a specialized topic which aims to cover current or past AI developments, as well as its potential impact and future prospects in cancer management. With the advent of deep learning, the application of AI in healthcare has grown significantly over the years; nevertheless, many of these current applications are task-specific or rigid to certain sets of input data. This has frequently limited the ability of deep learning tools to diverse and distinct data sources. Consequently, the focus going forward should be the development of generalized medical AI systems that can process and interpret multimodal data—such as images from various scans, laboratory results, blood-borne markers, wearable signals, microbiomes, and omics, as well as many inputs, such as unstructured or structured medical text, voice, and images. In this direction, generative AI and transformers could be vital technologies wherein a blended stream of diverse data tokens can be fed.

This research topic on the advancement, impact, and prospects of AI in the field of cancer holds great promise for revolutionizing healthcare delivery, enabling personalized medicine, democratizing technologies, and improving patient outcomes across diverse clinical applications. As research in this field continues to evolve, we can expect to see further innovations that will shape the future of AI in healthcare. The purpose of this research topic is to bring together new developments and advances within this field, providing valuable insights in current and future prospects of AI in healthcare specific to the field of cancer management. This research topic also welcomes literature reviews and work on focused areas such as AI explainability, bias mitigation, generalizability, futuristic applications, multi-modal aspects, and the validation of AI tools.

Manuscripts focused on the following areas are of particular interest to this research topic:

  • Recent developments in multi-modal AI for cancer screening, diagnosis, prognosis, risk prediction, and longitudinal risk monitoring;
  • Recent advances in AI for cancer treatment planning, preventative therapy, prediction of drug effectiveness, and digital drug development;
  • Innovative and futuristic AI tools for patient triage, workflow optimization, and diagnostic and treatment assistance to augmented procedures (e.g., image-to-text generation and image-to-voice generation for scoping or surgical procedure);
  • AI for predicting cancer patterns and risks from image biomarkers, wearable data, laboratory data, omics data, and microbiome data;
  • AI as a virtual health coach, AI to improve patient–doctor relationships, and AI to mitigate diagnostic errors;
  • AI for remote monitoring, home care, integration with teleconsultation, and affordable technologies for low-resource settings.

Dr. Arka Bhowmik
Guest Editor

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Keywords

  • AI for cancer forecasting
  • multi-modal AI
  • high-risk prediction
  • risk monitoring
  • preventive therapy
  • democratized AI technology
  • augmented procedures
  • doctor–patient relationship

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Published Papers (2 papers)

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Review

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33 pages, 3996 KiB  
Review
Deep Reinforcement Learning for Automated Insulin Delivery Systems: Algorithms, Applications, and Prospects
by Xia Yu, Zi Yang, Xiaoyu Sun, Hao Liu, Hongru Li, Jingyi Lu, Jian Zhou and Ali Cinar
AI 2025, 6(5), 87; https://doi.org/10.3390/ai6050087 - 23 Apr 2025
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Abstract
Advances in continuous glucose monitoring (CGM) technologies and wearable devices are enabling the enhancement of automated insulin delivery systems (AIDs) towards fully automated closed-loop systems, aiming to achieve secure, personalized, and optimal blood glucose concentration (BGC) management for individuals with diabetes. While model [...] Read more.
Advances in continuous glucose monitoring (CGM) technologies and wearable devices are enabling the enhancement of automated insulin delivery systems (AIDs) towards fully automated closed-loop systems, aiming to achieve secure, personalized, and optimal blood glucose concentration (BGC) management for individuals with diabetes. While model predictive control provides a flexible framework for developing AIDs control algorithms, models that capture inter- and intra-patient variability and perturbation uncertainty are needed for accurate and effective regulation of BGC. Advances in artificial intelligence present new opportunities for developing data-driven, fully closed-loop AIDs. Among them, deep reinforcement learning (DRL) has attracted much attention due to its potential resistance to perturbations. To this end, this paper conducts a literature review on DRL-based BGC control algorithms for AIDs. First, this paper systematically analyzes the benefits of utilizing DRL algorithms in AIDs. Then, a comprehensive review of various DRL techniques and extensions that have been proposed to address challenges arising from their integration with AIDs, including considerations related to low sample availability, personalization, and security are discussed. Additionally, the paper provides an application-oriented investigation of DRL-based AIDs control algorithms, emphasizing significant challenges in practical implementations. Finally, the paper discusses solutions to relevant BGC control problems, outlines prospects for practical applications, and suggests future research directions. Full article
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18 pages, 2558 KiB  
Systematic Review
Artificial Intelligence in Ovarian Cancer: A Systematic Review and Meta-Analysis of Predictive AI Models in Genomics, Radiomics, and Immunotherapy
by Mauro Francesco Pio Maiorano, Gennaro Cormio, Vera Loizzi and Brigida Anna Maiorano
AI 2025, 6(4), 84; https://doi.org/10.3390/ai6040084 - 18 Apr 2025
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Abstract
Background/Objectives: Artificial intelligence (AI) is increasingly influencing oncological research by enabling precision medicine in ovarian cancer through enhanced prediction of therapy response and patient stratification. This systematic review and meta-analysis was conducted to assess the performance of AI-driven models across three key [...] Read more.
Background/Objectives: Artificial intelligence (AI) is increasingly influencing oncological research by enabling precision medicine in ovarian cancer through enhanced prediction of therapy response and patient stratification. This systematic review and meta-analysis was conducted to assess the performance of AI-driven models across three key domains: genomics and molecular profiling, radiomics-based imaging analysis, and prediction of immunotherapy response. Methods: Relevant studies were identified through a systematic search across multiple databases (2020–2025), adhering to PRISMA guidelines. Results: Thirteen studies met the inclusion criteria, involving over 10,000 ovarian cancer patients and encompassing diverse AI models such as machine learning classifiers and deep learning architectures. Pooled AUCs indicated strong predictive performance for genomics-based (0.78), radiomics-based (0.88), and immunotherapy-based (0.77) models. Notably, radiogenomics-based AI integrating imaging and molecular data yielded the highest accuracy (AUC = 0.975), highlighting the potential of multi-modal approaches. Heterogeneity and risk of bias were assessed, and evidence certainty was graded. Conclusions: Overall, AI demonstrated promise in predicting therapeutic outcomes in ovarian cancer, with radiomics and integrated radiogenomics emerging as leading strategies. Future efforts should prioritize explainability, prospective multi-center validation, and integration of immune and spatial transcriptomic data to support clinical implementation and individualized treatment strategies. Unlike earlier reviews, this study synthesizes a broader range of AI applications in ovarian cancer and provides pooled performance metrics across diverse models. It examines the methodological soundness of the selected studies and highlights current gaps and opportunities for clinical translation, offering a comprehensive and forward-looking perspective in the field. Full article
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