Cancers (ISSN 2072-6694) is a peer-reviewed, open access oncology journal published semimonthly online, with 17 Sections open for submissions. We are pleased to recommend a selection of highly cited papers published in the journal in 2024–2025, which have earned Highly Cited Paper recognition from Web of Science. These papers also demonstrate strong view and download metrics, reflecting their broad impact in the field of oncology. We extend our sincere gratitude to all the authors for their outstanding contributions, innovative research, and continued efforts to advance cancer research. We hope these papers, covering a wide range of topics, will offer you valuable insights and inspiration.

“Comprehensive Review of Early and Late Toxicities in CAR T-Cell Therapy and Bispecific Antibody Treatments for Hematologic Malignancies”
by Ayrton Bangolo, Behzad Amoozgar, Charlene Mansour, Lili Zhang, Sarvarinder Gill, Andrew Ip and Christina Cho
Cancers 2025, 17(2), 282; https://doi.org/10.3390/cancers17020282
Available online: https://www.mdpi.com/2072-6694/17/2/282

“Management of Hepatocellular Carcinoma in 2024: The Multidisciplinary Paradigm in an Evolving Treatment Landscape”
by Emily Kinsey and Hannah M. Lee
Cancers 2024, 16(3), 666; https://doi.org/10.3390/cancers16030666
Available online: https://www.mdpi.com/2072-6694/16/3/666

“Risk Factors and Innovations in Risk Assessment for Melanoma, Basal Cell Carcinoma, and Squamous Cell Carcinoma”
by K. Wunderlich, M. Suppa, S. Gandini, J. Lipski, J. M. White and V. Del Marmol
Cancers 2024, 16(5), 1016; https://doi.org/10.3390/cancers16051016
Available online: https://www.mdpi.com/2072-6694/16/5/1016

“Glioblastoma: Clinical Presentation, Multidisciplinary Management, and Long-Term Outcomes”
by David Sipos, Bence L. Raposa, Omar Freihat, Mihály Simon, Nejc Mekis, Patrizia Cornacchione and Árpád Kovács
Cancers 2025, 17(1), 146; https://doi.org/10.3390/cancers17010146
Available online: https://www.mdpi.com/2072-6694/17/1/146

“Prognosis and Treatment of Gastric Cancer: A 2024 Update”
by Claudia Burz, Vlad Pop, Ciprian Silaghi, Iulia Lupan and Gabriel Samasca
Cancers 2024, 16(9), 1708; https://doi.org/10.3390/cancers16091708
Available online: https://www.mdpi.com/2072-6694/16/9/1708

“Colorectal Cancer: Epidemiology, Risk Factors, and Prevention”
by Gholamreza Roshandel, Fatemeh Ghasemi-Kebria and Reza Malekzadeh
Cancers 2024, 16(8), 1530; https://doi.org/10.3390/cancers16081530
Available online: https://www.mdpi.com/2072-6694/16/8/1530

“Unraveling the Burden of Pancreatic Cancer in the 21st Century: Trends in Incidence, Mortality, Survival, and Key Contributing Factors”
by Jakob Zottl, Christian Günther Sebesta, Elena Tomosel, Marie-Christine Sebesta and Christian Sebesta
Cancers 2025, 17(10), 1607; https://doi.org/10.3390/cancers17101607
Available online: https://www.mdpi.com/2072-6694/17/10/1607

“Immune-Related Adverse Events Due to Cancer Immunotherapy: Immune Mechanisms and Clinical Manifestations”
by Silvia Casagrande, Giulia Boscato Sopetto, Giovanni Bertalot, Roberto Bortolotti, Vito Racanelli, Orazio Caffo, Bruno Giometto, Alvise Berti and Antonello Veccia
Cancers 2024, 16(7), 1440; https://doi.org/10.3390/cancers16071440
Available online: https://www.mdpi.com/2072-6694/16/7/1440

“From Diagnosis to Survivorship: The Role of Social Determinants in Cancer Care”
by Abiha Abdullah, Zeyu Liu and Michele Molinari
Cancers 2025, 17(7), 1067; https://doi.org/10.3390/cancers17071067
Available online: https://www.mdpi.com/2072-6694/17/7/1067

“Differential Effects of GLP-1 Receptor Agonists on Cancer Risk in Obesity: A Nationwide Analysis of 1.1 Million Patients”
by Shauna Levy, Abdallah Attia, Rami M. Elshazli, Ahmed Abdelmaksoud, Danielle Tatum, Hani Aiash and Eman A. Toraih
Cancers 2025, 17(1), 78; https://doi.org/10.3390/cancers17010078
Available online: https://www.mdpi.com/2072-6694/17/1/78

“Recent Advances in Endometrial Cancer Prevention, Early Diagnosis and Treatment”
by Holly Baker-Rand and Sarah J. Kitson
Cancers 2024, 16(5), 1028; https://doi.org/10.3390/cancers16051028
Available online: https://www.mdpi.com/2072-6694/16/5/1028

“Management of Patients with Vulvar Cancers: A Systematic Comparison of International Guidelines (NCCN–ASCO–ESGO–BGCS–IGCS–FIGO–French Guidelines–RCOG)”
by Stefano Restaino, Giulia Pellecchia, Martina Arcieri, Giorgio Bogani, Cristina Taliento, Pantaleo Greco, Lorenza Driul, Vito Chiantera, Rosa Pasqualina De Vincenzo, Giorgia Garganese et al.
Cancers 2025, 17(2), 186; https://doi.org/10.3390/cancers17020186
Available online: https://www.mdpi.com/2072-6694/17/2/186

“Microplastics in the Human Body: Exposure, Detection, and Risk of Carcinogenesis: A State-of-the-Art Review”
by Eliasz Dzierżyński, Piotr J. Gawlik, Damian Puźniak, Wojciech Flieger, Katarzyna Jóźwik, Grzegorz Teresiński, Alicja Forma, Paulina Wdowiak, Jacek Baj and Jolanta Flieger
Cancers 2024, 16(21), 3703; https://doi.org/10.3390/cancers16213703
Available online: https://www.mdpi.com/2072-6694/16/21/3703

“Opportunities and Challenges in Antibody–Drug Conjugates for Cancer Therapy: A New Era for Cancer Treatment”
by Idil Buyukgolcigezli, Ates Kutay Tenekeci and Ibrahim Halil Sahin
Cancers 2025, 17(6), 958; https://doi.org/10.3390/cancers17060958
Available online: https://www.mdpi.com/2072-6694/17/6/958

“Enhancing Tumor Targeted Therapy: The Role of iRGD Peptide in Advanced Drug Delivery Systems”
by Dragana Nikitovic, Ekaterina Kukovyakina, Aikaterini Berdiaki, Alexandros Tzanakakis, Anna Luss, Elizaveta Vlaskina, Anne Yagolovich, Aristides Tsatsakis and Andrey Kuskov
Cancers 2024, 16(22), 3768; https://doi.org/10.3390/cancers16223768
Available online: https://www.mdpi.com/2072-6694/16/22/3768

“The Role of Curcumin in Cancer: A Focus on the PI3K/Akt Pathway”
by Vasiliki Zoi, Athanassios P. Kyritsis, Vasiliki Galani, Diamanto Lazari, Chrissa Sioka, Spyridon Voulgaris and Georgios A. Alexiou
Cancers 2024, 16(8), 1554; https://doi.org/10.3390/cancers16081554
Available online: https://www.mdpi.com/2072-6694/16/8/1554

“Antibody–Drug Conjugates: The Dynamic Evolution from Conventional to Next-Generation Constructs”
by Virginia Metrangolo and Lars H. Engelholm
Cancers 2024, 16(2), 447; https://doi.org/10.3390/cancers16020447
Available online: https://www.mdpi.com/2072-6694/16/2/447

“Optimizing Osimertinib for NSCLC: Targeting Resistance and Exploring Combination Therapeutics”
by Yan-You Liao, Chia-Luen Tsai and Hsiang-Po Huang
Cancers 2025, 17(3), 459; https://doi.org/10.3390/cancers17030459
Available online: https://www.mdpi.com/2072-6694/17/3/459

You can browse more high-impact research by visiting our Most Cited & Viewed Section, where all full-text articles are freely accessible: https://www.mdpi.com/journal/cancers/most_cited.

We invite you to read these papers and consider Cancers for your next manuscript submission. To learn more about our journal and submit your research, please visit: https://www.mdpi.com/journal/cancers.

Cancers Editorial Office