Journal of Clinical Medicine (JCM, ISSN: 2077-0383) is an open access journal with an updated CiteScore (2023) of 5.7, ranked 80/636 (Q1) in the “General Medicine” category. This is a direct result of the numerous high-quality, highly cited papers that have graced their pages. These papers not only showcase cutting-edge research in clinical medicine but also contribute significantly to the journal. A huge thank you to all the authors for their invaluable contributions. We invite you to enjoy and review part I of these papers together, hoping to bring different inspirations.

1. “2023 Update on Sepsis and Septic Shock in Adult Patients: Management in the Emergency Department”
by Matteo Guarino, Benedetta Perna, Alice Eleonora Cesaro, Martina Maritati, Michele Domenico Spampinato, Carlo Contini and Roberto De Giorgio
J. Clin. Med. 2023, 12(9), 3188; https://doi.org/10.3390/jcm12093188
Full text available online: https://www.mdpi.com/2077-0383/12/9/3188

2. “Polycystic Ovary Syndrome: Etiology, Current Management, and Future Therapeutics”
by Samradhi Singh, Namrata Pal, Swasti Shubham, Devojit Kumar Sarma, Vinod Verma, Francesco Marotta and Manoj Kumar
J. Clin. Med. 2023, 12(4), 1454; https://doi.org/10.3390/jcm12041454
Full text available online: https://www.mdpi.com/2077-0383/12/4/1454

3. “Noise-Induced Hearing Loss”
by Nirvikalpa Natarajan, Shelley Batts and Konstantina M. Stankovic
J. Clin. Med. 2023, 12(6), 2347; https://doi.org/10.3390/jcm12062347
Full text available online: https://www.mdpi.com/2077-0383/12/6/2347

4. “Chronic Low Back Pain: A Narrative Review of Recent International Guidelines for Diagnosis and Conservative Treatment”
by Vanina Nicol, Claire Verdaguer, Camille Daste, Hélène Bisseriex, Éric Lapeyre, Marie-Martine Lefèvre-Colau, François Rannou, Alexandra Rören, Julia Facione and Christelle Nguyen
J. Clin. Med. 2023, 12(4), 1685; https://doi.org/10.3390/jcm12041685
Full text available online: https://www.mdpi.com/2077-0383/12/4/1685

5. “Systemic Immune Inflammation Index (SII), System Inflammation Response Index (SIRI) and Risk of All-Cause Mortality and Cardiovascular Mortality: A 20-Year Follow-Up Cohort Study of 42,875 US Adults”
by Yiyuan Xia, Chunlei Xia, Lida Wu, Zheng Li, Hui Li and Junxia Zhang
J. Clin. Med. 2023, 12(3), 1128; https://doi.org/10.3390/jcm12031128
Full text available online: https://www.mdpi.com/2077-0383/12/3/1128

6. “Advances in Therapies to Treat Neonatal Hypoxic-Ischemic Encephalopathy”
by Amaresh K. Ranjan and Anil Gulati
J. Clin. Med. 2023, 12(20), 6653; https://doi.org/10.3390/jcm12206653
Full text available online: https://www.mdpi.com/2077-0383/12/20/6653

7. “Current Treatment Landscape for Early Triple-Negative Breast Cancer (TNBC)”
by Jieun Lee
J. Clin. Med. 2023, 12(4), 1524; https://doi.org/10.3390/jcm12041524
Full text available online: https://www.mdpi.com/2077-0383/12/4/1524

8. “Past, Present and (Foreseeable) Future of Biological Anti-TNF Alpha Therapy”
by Gian Marco Leone, Katia Mangano, Maria Cristina Petralia, Ferdinando Nicoletti and Paolo Fagone
J. Clin. Med. 2023, 12(4), 1630; https://doi.org/10.3390/jcm12041630
Full text available online: https://www.mdpi.com/2077-0383/12/4/1630

9. “Stage IV Colorectal Cancer Management and Treatment”
by Oscar Hernandez Dominguez, Sumeyye Yilmaz and Scott R. Steele
J. Clin. Med. 2023, 12(5), 2072; https://doi.org/10.3390/jcm12052072
Full text available online: https://www.mdpi.com/2077-0383/12/5/2072

10. “Recurrent Pregnancy Loss Etiology, Risk Factors, Diagnosis, and Management. Fresh Look into a Full Box”
by Akbayan Turesheva, Gulzhanat Aimagambetova, Talshyn Ukybassova, Aizada Marat, Perizat Kanabekova, Lyazzat Kaldygulova, Ainur Amanzholkyzy, Svetlana Ryzhkova, Anastassiya Nogay, Zaituna Khamidullina et al.
J. Clin. Med. 2023, 12(12), 4074; https://doi.org/10.3390/jcm12124074
Full text available online: https://www.mdpi.com/2077-0383/12/12/4074

11. “Irritable Bowel Syndrome and the Gut Microbiome: A Comprehensive Review”
by Sofia D. Shaikh, Natalie Sun, Andrew Canakis, William Y. Park and Horst Christian Weber
J. Clin. Med. 2023, 12(7), 2558; https://doi.org/10.3390/jcm12072558
Full text available online: https://www.mdpi.com/2077-0383/12/7/2558

12. “The Global Burden of Valvular Heart Disease: From Clinical Epidemiology to Management”
by Gloria Santangelo, Francesca Bursi, Andrea Faggiano, Silvia Moscardelli, Pasquale Simone Simeoli, Marco Guazzi, Roberto Lorusso, Stefano Carugo and Pompilio Faggiano
J. Clin. Med. 2023, 12(6), 2178; https://doi.org/10.3390/jcm12062178
Full text available online: https://www.mdpi.com/2077-0383/12/6/2178