Multifaceted Physiological Roles of Adiponectin in Inflammation and Diseases
Abstract
:1. Introduction
2. Adiponectin
2.1. Brief Overview of Adipose Tissue and Adiponectin Biology
2.2. Adiponectin Isoform
2.3. Different Physiological Roles of the Adiponectin Binding Receptors of AdipoR1, AdipoR2, and T-Cadherin
3. Signaling Proteins in Adiponectin-Stimulated Signaling Pathways
3.1. Adaptor Protein Containing a Pleckstrin Homology Domain (APPL) 1 Protein
3.2. Adaptor Protein Containing Pleckstrin Homology Domain (APPL) 2 Protein
3.3. Signaling Pathways of Adiponectin-Mediated Metabolism
4. Beneficial Effect of Adiponectin in Metabolic Tissues
4.1. Effect of Adiponectin on Adipose Tissue
4.2. Effect of Adiponectin on Skeletal Muscle
4.3. Effect of Adiponectin on Vascular Endothelium
4.4. Effect of Adiponectin on Macrophages
4.5. Insulin Sensitizing Action of Adiponectin
5. Is Adiponectin Anti-Inflammatory or Proinflammatory?
5.1. Diseases Associated with Anti-Inflammatory Effects of Adiponectin
5.1.1. Anti-Inflammatory Role of Adiponectin in Atherosclerosis
5.1.2. Anti-Inflammatory Role of Adiponectin in Obesity and Type 2 Diabetes
5.2. Diseases Associated with Pro-Inflammatory Effects of Adiponectin
5.2.1. Pro-Inflammatory Role of Adiponectin in Rheumatoid Arthritis (RA)
5.2.2. Pro-Inflammatory Role of Adiponectin in Chronic Kidney Disease (CKD)
5.2.3. Pro-Inflammatory Role of Adiponectin in Inflammatory Bowel Disease
6. Differential Effects of Adiponectin Isoforms and Their Controversies
6.1. Issues Related to HMW: Pro-Inflammatory or Anti-Inflammatory
6.2. Globular Adiponectin with a Pro-Inflammatory Effect
7. Conclusions
Author Contributions
Funding
Conflicts of Interest
Abbreviations
WAT | white adipose tissue |
HMW | high-molecular weight adiponectin |
MMW | middle-molecular weight adiponectin |
LMW | low-molecular weight adiponectin |
AMPK | adenosine monophosphate-activated protein kinase |
P38 MAPK | p38 mitogen-activated protein kinase |
PPARα | peroxisome proliferator-activated receptor-α |
APPL | adaptor protein containing a pleckstrin homology domain |
NF-κB | nuclear factor κ-light-chain-enhancer of activated B cells |
TNF-α | tumor necrosis factor-α |
NO | nitric oxide |
AdipoR | adiponectin receptor |
T2B | type 2 diabetes |
RA | rheumatoid arthritis |
CKD | chronic kidney disease |
IRS | insulin receptor substrate |
IR | insulin receptor tyrosine kinase |
TLR | toll-like receptor |
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Choi, H.M.; Doss, H.M.; Kim, K.S. Multifaceted Physiological Roles of Adiponectin in Inflammation and Diseases. Int. J. Mol. Sci. 2020, 21, 1219. https://doi.org/10.3390/ijms21041219
Choi HM, Doss HM, Kim KS. Multifaceted Physiological Roles of Adiponectin in Inflammation and Diseases. International Journal of Molecular Sciences. 2020; 21(4):1219. https://doi.org/10.3390/ijms21041219
Chicago/Turabian StyleChoi, Hyung Muk, Hari Madhuri Doss, and Kyoung Soo Kim. 2020. "Multifaceted Physiological Roles of Adiponectin in Inflammation and Diseases" International Journal of Molecular Sciences 21, no. 4: 1219. https://doi.org/10.3390/ijms21041219