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Therapeutics, Volume 2, Issue 3 (September 2025) – 1 article

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18 pages, 2614 KiB  
Review
The Golden Hamster: A Valuable Model for Designing Cancer Therapies
by Mahmoud Singer, David K. Imagawa, Michael Alexander and Nadine Abi-Jaoudeh
Therapeutics 2025, 2(3), 10; https://doi.org/10.3390/therapeutics2030010 - 20 Jun 2025
Abstract
Animal models are indispensable in biomedical research, offering critical insights into disease mechanisms and therapeutic strategies. However, existing models often inadequately replicate human pathophysiology, leading to discrepancies between preclinical and clinical outcomes. Despite their contributions, many models exhibit significant limitations, especially concerning cancer [...] Read more.
Animal models are indispensable in biomedical research, offering critical insights into disease mechanisms and therapeutic strategies. However, existing models often inadequately replicate human pathophysiology, leading to discrepancies between preclinical and clinical outcomes. Despite their contributions, many models exhibit significant limitations, especially concerning cancer and infectious diseases. Inaccurate modeling of human biological responses can result in failed clinical trials, escalated research costs, and delays in developing effective treatments. The golden hamster (Mesocricetus auratus) has emerged as a viable model, particularly in cancer and infectious disease research. Sharing physiological and immunological profiles similar to humans, the golden hamster offers distinct advantages over other rodent models, such as mice and rats. This review explores the benefits of using golden hamsters in cancer research, highlighting their contributions to scientific advancements while also addressing the limitations due to incomplete immunological and molecular knowledge about this species. Full article
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