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Gout, Urate, and Crystal Deposition Disease, Volume 3, Issue 2

2025 June - 6 articles

Cover Story: Xanthine oxidoreductase (XOR) inhibitors effectively lower serum urate levels, but their effects extend to purine and energy metabolism. This review connects insights from hereditary xanthinuria with clinical findings associated with XOR inhibitors, examining how the abrupt cessation of potent XOR inhibitors may trigger a rapid increase in serum urate levels and elevate the risk of cardiovascular events. We emphasize the importance of careful planning in treatment discontinuation and discuss strategies to address metabolic risks. View this paper
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Articles (6)

  • Conference Report
  • Open Access
2,469 Views
32 Pages

The tenth annual international G-CAN research symposium was held in Alexandria, VA on the 13th and 14th of November 2024. This hybrid meeting, a live face-to-face and virtual live symposium, was attended by 201 participants. Over 20 research abstract...

  • Feature Paper
  • Review
  • Open Access
6,689 Views
12 Pages

Xanthine oxidoreductase (XOR) is the only enzyme responsible for uric acid production and is essential for preventing gout. While XOR inhibitors effectively reduce serum urate levels, they also influence purine salvage and de novo pathways, as well a...

  • Review
  • Open Access
2 Citations
2,714 Views
15 Pages

Background: Mendelian randomization (MR) is a genetic epidemiological method used to infer causal relationships between exposures and outcomes. Its application in hyperuricemia and gout has grown exponentially owing to the ready availability of summa...

  • Review
  • Open Access
1 Citations
3,755 Views
22 Pages

Comparison of Pathophysiological Mechanisms Among Crystal-Induced Arthropathies

  • Maddalena Zangari,
  • Roberto Luisetto,
  • Roberto Pilot,
  • Paola Contessa,
  • Raffaella Signorini,
  • Stefano Masiero and
  • Anna Scanu

Monosodium urate, calcium pyrophosphate, and basic calcium phosphate crystals are the most common types of crystals found in the joints. Each type of crystal has been associated with the onset of different joint diseases. However, the mechanisms iden...

  • Article
  • Open Access
2 Citations
1,969 Views
15 Pages

Colocalization Analysis Reveals Shared Genetic Loci Contributing to Gout and Metabolite Levels

  • Riku Takei,
  • Nicholas A. Sumpter,
  • Megan P. Leask and
  • Tony R. Merriman

Genetic association studies in gout have identified genetic variants in or near genes involved in the biosynthesis and transport of urate and in immunological pathways. However, the causal role of the remaining genetic variants, genes, and pathways i...

  • Article
  • Open Access
1,541 Views
6 Pages

Calcium pyrophosphate deposition disease (CPPD) has been shown to be associated with inflammatory arthritis such as rheumatoid arthritis. However, few studies have investigated the correlation between CPPD and psoriatic arthritis (PsA). Our study aim...

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Gout Urate Cryst. Depos. Dis. - ISSN 2813-4583