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Sclerosis
Volume 4
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10.3390/sclerosis4010003
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Communication

Short Report: Treadmill Walking Differs from Overground Walking in Multiple Sclerosis

by
Herbert Karpatkin
1,*,
Jaya Rachwani
1,
Evan T. Cohen
2,
Anna Rubeo
1,
Gene Hetz
1,
Rosangelis Rodriguez
1 and
Lourdes Rodriguez
1
1
Physical Therapy Department, Hunter College, City University of New York, New York, NY 10010, USA
2
Physical Therapy Department, Arcadia University, Glenside, PA 19038, USA
*
Author to whom correspondence should be addressed.
Sclerosis 2026, 4(1), 3; https://doi.org/10.3390/sclerosis4010003
Submission received: 25 November 2025 / Revised: 5 January 2026 / Accepted: 8 January 2026 / Published: 16 January 2026
(This article belongs to the Special Issue Advances in Balance and Gait Assessment, Monitoring and Rehabilitation in Multiple Sclerosis)
Versions Notes

Abstract

Background/Objectives: Gait impairment is a common finding in multiple sclerosis (MS). Clinicians have used both treadmill and overground walking for its evaluation and treatment. However, there is little evidence that these two types of walking are equivalent. Methods: An incidental finding from another study revealed differences between treadmill and overground walking speed in 24 persons with MS. We compared this to walking speed in healthy controls walking in the same two conditions. Results: Walking speed was significantly reduced on the treadmill relative to overground walking in persons with MS, while there was no difference between the two conditions for controls. Conclusions: Clinicians should consider that treadmill walking may not generalize to overground walking in this population.
Keywords: multiple sclerosis; walking; treadmill multiple sclerosis; walking; treadmill

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MDPI and ACS Style

Karpatkin, H.; Rachwani, J.; Cohen, E.T.; Rubeo, A.; Hetz, G.; Rodriguez, R.; Rodriguez, L. Short Report: Treadmill Walking Differs from Overground Walking in Multiple Sclerosis. Sclerosis 2026, 4, 3. https://doi.org/10.3390/sclerosis4010003

AMA Style

Karpatkin H, Rachwani J, Cohen ET, Rubeo A, Hetz G, Rodriguez R, Rodriguez L. Short Report: Treadmill Walking Differs from Overground Walking in Multiple Sclerosis. Sclerosis. 2026; 4(1):3. https://doi.org/10.3390/sclerosis4010003

Chicago/Turabian Style

Karpatkin, Herbert, Jaya Rachwani, Evan T. Cohen, Anna Rubeo, Gene Hetz, Rosangelis Rodriguez, and Lourdes Rodriguez. 2026. "Short Report: Treadmill Walking Differs from Overground Walking in Multiple Sclerosis" Sclerosis 4, no. 1: 3. https://doi.org/10.3390/sclerosis4010003

APA Style

Karpatkin, H., Rachwani, J., Cohen, E. T., Rubeo, A., Hetz, G., Rodriguez, R., & Rodriguez, L. (2026). Short Report: Treadmill Walking Differs from Overground Walking in Multiple Sclerosis. Sclerosis, 4(1), 3. https://doi.org/10.3390/sclerosis4010003

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