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Future Pharmacology, Volume 5, Issue 1

2025 March - 13 articles

Cover Story: Exosomes transport biomolecules and mediate inter-tissue communication in metabolic regulation via endocrine mechanisms, playing a crucial role in obesity, type 2 diabetes, and cardiovascular diseases. This study explores their impact on the liver, pancreas, skeletal muscle, intestine, and adipose tissue, introducing the “exosomal pentad” as a model linking these organs. Exosomes influence insulin sensitivity, lipid metabolism, and inflammation by transporting miRNAs, proteins, and lipids. Their therapeutic potential is demonstrated in applications such as integrin blockade, nanoparticle-based interventions, and molecular targeting. These strategies could enable the development of precise metabolic disease treatments, reducing systemic side effects while enhancing efficacy, making exosomes key candidates for next-generation pharmacological approaches. View this paper
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Articles (13)

  • Article
  • Open Access
2 Citations
1,129 Views
14 Pages

Background/Objectives: Microcolins A–M are cytotoxic marine lipopeptides produced by the cyanobacterium Moorena producens, also known as Lyngbya majuscula. Recent studies have shown that two compounds in the series, microcolins B and H, ca...

  • Article
  • Open Access
1,801 Views
21 Pages

Background/Objectives: Flavones, a class of plant-based flavonoids, have demonstrated conflicting anti-melanogenic activities in mouse and human melanocytes. Sinensetin (SNT), a polymethoxyflavone, has shown pro-melanogenic activity in B16F10 mouse m...

  • Review
  • Open Access
9 Citations
5,422 Views
22 Pages

Inter-Tissue Communication Mechanisms via Exosomes and Their Implications in Metabolic Diseases: Opportunities for Pharmacological Regulation

  • Brenda Chimal-Vega,
  • Jesus Emanuel Maldonado-Arvizu,
  • Alex Daniel Hernández Avalos,
  • José Fernando Díaz-Villanueva,
  • Luis Pablo Avila-Barrientos and
  • Victor G. García González

Exosomes can transport regulatory biomolecules and are mediators of cellular signaling among metabolic tissues through endocrine mechanisms. Understanding the pathways and processes underlying exosome-mediated inter-tissue communication is critical f...

  • Article
  • Open Access
1 Citations
1,733 Views
12 Pages

Water-Soluble Cu(II) Complexes with Polypyridyl Ligands: Anticancer Activity and DNA Interaction

  • Herisson F. dos Santos,
  • Nádija N. P. da Silva,
  • George B. S. Pereira,
  • Mauro A. Lima,
  • Nailton M. Nascimento-Júnior,
  • Renan L. de Farias,
  • Amos O. Akinyemi and
  • Fillipe V. Rocha

Background/Objectives: Cu(II) complexes with polypyridine ligands have shown carcinogenic activity already described in the literature and appear as a possible alternative to cisplatin, which has several side effects. In view of this, four Cu(II) com...

  • Article
  • Open Access
1 Citations
1,961 Views
22 Pages

Discovery of Arylfuran and Carbohydrate Derivatives from the BraCoLi Library as Potential Zika Virus NS3pro Inhibitors

  • Fernanda Kelly Marcelino e Oliveira,
  • Beatriz Murta Rezende Moraes Ribeiro,
  • Ellen Gonçalves de Oliveira,
  • Marina Mol Sena Andrade Verzola,
  • Thales Kronenberger,
  • Vinícius Gonçalves Maltarollo,
  • Ricardo José Alves,
  • Renata Barbosa de Oliveira,
  • Rafaela Salgado Ferreira and
  • Mateus Sá Magalhães Serafim
  • + 1 author

Background/Objectives: Zika fever is a disease caused by the Zika virus (ZIKV). Symptomatic cases may be associated with neurological disorders in adults, as well as congenital Zika syndrome and other birth defects during pregnancy. In 2016, Zika fev...

  • Communication
  • Open Access
2 Citations
2,366 Views
17 Pages

The Effect of Agave Bagasse Extract on Wound Healing in a Murine Model

  • Herminia López-Salazar,
  • Elizabeth Negrete-León,
  • Brenda Hildeliza Camacho-Díaz,
  • Juan José Acevedo-Fernández,
  • Sandra Victoria Ávila-Reyes and
  • Martha L. Arenas Ocampo

Background/Objectives: The development of bioproducts that can accelerate wound healing is a key focus in biomedicine, especially when these products are derived from sustainable by-products. This study investigates the wound-healing potential of an...

  • Review
  • Open Access
8 Citations
5,113 Views
16 Pages

Why Do Glioblastoma Treatments Fail?

  • Alen Rončević,
  • Nenad Koruga,
  • Anamarija Soldo Koruga and
  • Robert Rončević

Glioblastoma (GBM) is the most aggressive brain tumor, characterized by high recurrence rates and poor patient outcomes. Treatment failure is driven by multiple factors, including complex tumor heterogeneity, the presence of cancer stem cells, the im...

  • Communication
  • Open Access
4 Citations
2,946 Views
11 Pages

Background/Objectives: Umckalin, a coumarin derivative abundantly present in the root extract of Pelargonium sidoides, is a key bioactive compound known for its antimicrobial, antiviral, antitubercular, and immunomodulatory properties. Its therapeuti...

  • Review
  • Open Access
2 Citations
3,964 Views
17 Pages

An Overview of Sargassum Seaweed as Natural Anticancer Therapy

  • Kelly Johanna Muñoz-Losada,
  • Manuela Gallego-Villada and
  • Miguel Angel Puertas-Mejía

Algae have great therapeutic value and have attracted a great deal of attention due to the abundance of bioactive compounds they contain, which may be the key to fighting diseases of various origins, such as skin cancer, breast cancer, or osteosarcom...

  • Review
  • Open Access
2 Citations
2,155 Views
19 Pages

Breast cancer is the leading cause of tumor-related death in women around much of the world and a major health burden for modern medicine. This review highlights the prospect of (Nd3+) complexes and nanoparticles as promising novel anticancer agents...

  • Review
  • Open Access
9 Citations
4,340 Views
20 Pages

An Updated Review of the Antimicrobial Potential of Selenium Nanoparticles and Selenium-Related Toxicological Issues

  • Tainá Pereira da Silva Oliveira,
  • Alan Kelbis Oliveira Lima and
  • Luís Alexandre Muehlmann

Discovered in mid-1817 by Jöns Jacob Berzelius, selenium, belonging to Group 16 of the periodic table is an essential trace element for human and animal health, due to its biocompatibility and bioavailability. Additionally, it is known for havin...

  • Review
  • Open Access
3 Citations
20,157 Views
14 Pages

Sodium Nitroprusside: The Forgotten Vasodilator? A Brief Guide for Informed and Safe Use from Heart Failure to Hypertensive Crisis and Aortic Dissection

  • Saverio D’Elia,
  • Rosa Franzese,
  • Carmine Gentile,
  • Achille Solimene,
  • Ettore Luisi,
  • Antonio Caiazzo,
  • Francesco Natale,
  • Francesco S. Loffredo,
  • Paolo Golino and
  • Giovanni Cimmino

Sodium nitroprusside (SNP) is a powerful vasodilator approved for treating acute hypertensive crises, acute heart failure, aortic dissection, and both controlled perioperative hypotension and perioperative hypertension. Its unique ability to cause bo...

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Future Pharmacol. - ISSN 2673-9879